Detalhe da pesquisa
1.
Conserved reduction of m6A RNA modifications during aging and neurodegeneration is linked to changes in synaptic transcripts.
Proc Natl Acad Sci U S A
; 120(9): e2204933120, 2023 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36812208
2.
Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors.
Nature
; 534(7605): 129-32, 2016 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27251290
3.
Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists.
Bioorg Med Chem Lett
; 24(23): 5478-83, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25455488
4.
Discovery of structurally novel, potent and orally efficacious GPR119 agonists.
Bioorg Med Chem Lett
; 24(10): 2383-7, 2014 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24751443
5.
Effective exosomes reduction in hypercholesterinemic patients suffering from cardiovascular diseases by lipoprotein apheresis: Exosomes apheresis.
Ther Apher Dial
; 2024 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38837319
6.
The Coding and Small Non-coding Hippocampal Synaptic RNAome.
Mol Neurobiol
; 58(6): 2940-2953, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-33569760
7.
Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy.
Nat Commun
; 12(1): 6530, 2021 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34764281
8.
Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3-d]pyrimidine RET Inhibitors.
ACS Med Chem Lett
; 12(12): 1912-1919, 2021 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34917254
9.
Efficacy and Tolerability of Pyrazolo[1,5-a]pyrimidine RET Kinase Inhibitors for the Treatment of Lung Adenocarcinoma.
ACS Med Chem Lett
; 11(4): 558-565, 2020 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32292564
10.
Discovery of Orally Active Hydroxyethylamine Based SPPL2a Inhibitors.
ACS Med Chem Lett
; 10(6): 887-892, 2019 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31223443
11.
Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo.
J Med Chem
; 61(3): 865-880, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29359565
12.
A Functional Gradient in the Rodent Prefrontal Cortex Supports Behavioral Inhibition.
Curr Biol
; 27(4): 549-555, 2017 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28190729
13.
Correction to: The Coding and Small Non-coding Hippocampal Synaptic RNAome.
Mol Neurobiol
; 58(6): 2954, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-33710584
14.
Amygdala Regulation Following fMRI-Neurofeedback without Instructed Strategies.
Front Hum Neurosci
; 10: 183, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27199706
15.
Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers.
J Med Chem
; 59(14): 6671-89, 2016 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27433829
16.
EGF816 Exerts Anticancer Effects in Non-Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor.
Cancer Res
; 76(6): 1591-602, 2016 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26825170
17.
Flavin- and Deazaflavin-Containing Model Compounds Mimic the Energy Transfer Step in Type-II DNA-Photolyases.
Angew Chem Int Ed Engl
; 37(7): 938-941, 1998 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29711484
18.
Novel bisaryl substituted thiazoles and oxazoles as highly potent and selective peroxisome proliferator-activated receptor delta agonists.
J Med Chem
; 53(1): 77-105, 2010 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19928766
19.
A new approach to osmium-catalyzed asymmetric dihydroxylation and aminohydroxylation of olefins.
Angew Chem Int Ed Engl
; 41(3): 472-5, 2002 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12491382
20.
Bicyclic carbamates as inhibitors of papain-like cathepsin proteases.
Bioorg Med Chem Lett
; 17(5): 1254-9, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17196818