Attentional capture in goal-directed action during childhood, adolescence, and early adulthood.

Attentional capture occurs when salient but task-irrelevant information disrupts our ability to respond to task-relevant information. Although attentional capture costs have been found to decrease between childhood and adulthood, it is currently unclear the extent to which such age-related changes reflect an improved ability to recover from attentional capture or to avoid attentional capture. In addition, recent research using hand-tracking techniques with adults indicates that attentional capture by a distractor can generate response activations corresponding to the distractor's location, consistent with action-centered models of attention. However, it is unknown whether attentional capture can also result in the capture of action in children and adolescents. Therefore, we presented 5-year-olds, 9-year-olds, 13- and 14-year-olds, and adults (N = 96) with a singleton search task in which participants responded by reaching to touch targets on a digital display. Consistent with action-centered models of attention, distractor effects were evident in each age group's movement trajectories. In contrast to movement trajectories, movement times revealed significant age-related reductions in the costs of attentional capture, suggesting that age-related improvements in attentional control may be driven in part by an enhanced ability to recover from-as opposed to avoid-attentional capture. Children's performance was also significantly affected by response repetition effects, indicating that children may be more susceptible to interference from a wider range of task-irrelevant factors than adults. In addition to presenting novel insights into the development of attention and action, these results highlight the benefits of incorporating hand-tracking techniques into developmental research.

Tracking the Within-Trial, Cross-Trial, and Developmental Dynamics of Cognitive Control: Evidence From the Simon Task.

Six- to 8-year-olds, 10- to 12-year-olds, and adults (N = 108) performed the Simon task by reaching to targets on a digital display. The spatial and temporal characteristics of their movements were used to assess how two key processes underlying cognitive control-a threshold adjustment process and a controlled selection process-unfold over the course of a response (within-trial dynamics), are modulated by recent experience (cross-trial dynamics), and contribute to age-related gains in control (developmental dynamics). The results indicate that the controlled selection process undergoes a more protracted development than the threshold adjustment process. The results also shed light on a prominent debate concerning the cross-trial dynamics of control by supporting the feature integration account over the conflict adaptation account.

Reach tracking reveals dissociable processes underlying inhibitory control in 5- to 10-year-olds and adults.

Researchers have proposed that two processes featuring distinct types of inhibition support inhibitory control: a response threshold adjustment process involving the global inhibition of motor output and a conflict resolution process involving competitive inhibition among co-active response alternatives. To target the development of these processes, we measured the reaching behavior of 5- to 10-year-olds (Experiment 1) and adults (Experiment 2) as they performed an Eriksen flanker task. This method provided two key measures: initiation time (the time elapsed between stimulus onset and movement onset) and reach curvature (the degree to which a movement deviates from a direct path to the selected target). We suggest that initiation time reflects the response threshold adjustment process by indexing the degree of motoric stopping experienced before a movement is started, while reach curvature reflects the conflict resolution process by indexing the degree of co-activation between response alternatives over the course of a movement. Our results support this claim, revealing different patterns effects in initiation time and curvature, and divergent developmental trajectories between childhood and adulthood. These findings provide behavioral evidence for the dissociation between global and competitive inhibition, and offer new insight into the development of inhibitory control.

Physical, Cognitive, and Psychological Disability Following Critical Illness: What Is the Risk?

Critical illnesses affect millions of individuals annually in the United States. As advances in patient care continue to improve, the number of survivors is rapidly growing. Critical illness survivors endure profoundly severe illnesses and live through often frightening experiences throughout the course of ICU hospitalization, resulting in a variety of "survivorship" challenges, expressed through a condition known as post-intensive care syndrome (PICS). Questions abound regarding the ideal protocols for ensuring the best physical, cognitive, and psychological outcomes for these survivors. Organizational change is likely to be a key factor, though the specific components have not yet been established. Throughout this article, we highlight some of the barriers and facilitators to enhancing patient care across the spectrum of critical care environments, while also highlighting the challenges inherent to studying a complex patient population. We address each of the areas potentially affected by critical illness and ICU hospitalization--physical, cognitive, and psychological functional domains--experienced by patients as well as their family caregivers.

Revisiting causal pluralism: Intention, process, and dependency in cases of double prevention.

Causal pluralism proposes that humans can reason about causes and effects in terms of both dependency and process relations, depending on the scenario. Support for this view is provided by responses to double prevention scenarios in which an affector attempts to bring about an outcome, a preventer attempts to prevent the outcome, and a double preventer intervenes to stop the preventer's prevention attempt. Previous research indicates that reasoners award the affector high causal ratings regardless of whether their action was executed intentionally, whereas reasoners only award the double preventer high causal ratings when the double preventer acts intentionally. These results were interpreted as evidence that intentional actions prompt reasoners to differentially weight separately maintained representations of dependency and process relations. The current study presents three challenges to this causal pluralism account by (1) questioning whether intentionality only affects causal ratings by increasing the weighting placed on dependency relations during reasoning (Experiments 1-2), (2) presenting evidence consistent with the possibility that reasoners interpret the double preventer's action in terms of a process relation (Experiments 1-2), and (3) demonstrating that an unintentional double preventer can receive significantly higher causal ratings than an intentional affector when the order in which the characters act is altered (Experiments 3-4). These results underscore the need to revisit fundamental questions regarding how reasoners form, maintain, and reason over representations of causal scenarios featuring intentional actions.

Cognitive control across the lifespan: Congruency effects reveal divergent developmental trajectories.

The Simon, Stroop, and Eriksen flanker tasks are commonly used to assess cognitive control across the lifespan. However, it remains unclear whether these three tasks in fact measure the same cognitive abilities and in the same proportion. We take a developmental approach to this question: if the Simon, Stroop, and flanker tasks all roughly measure the same capacity, they should show similar patterns of age-related change. We present data from two massive online cross-sectional studies: Study 1 included 9,585 native English speakers between 10 and 80 years of age who completed the Simon and Stroop tasks, and Study 2 included 13,448 English speakers between 10 and 79 years of age who completed the flanker task. Of the three tasks, only the flanker task revealed an inverted U-shaped developmental trajectory, with performance improving until approximately 23 years of age and declining starting around 40 years of age. Performance on the Simon and Stroop tasks peaked around 34 and 26 years of age, respectively, and did not decline significantly in later life, though it is possible that age-related declines would be observed with more difficult versions of the tasks. Although the Simon and Stroop tasks are commonly interpreted to target similar underlying processes, we observed near zero correlations between the congruency effects observed in each task in terms of both accuracy and response time. We discuss these results in light of recent debates regarding the suitability of these tasks for assessing developmental and individual differences in cognitive control. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Moving beyond response times with accessible measures of manual dynamics.

Button-press measures of response time (RT) and accuracy have long served a central role in psychological research. However, RT and accuracy provide limited insight into how cognitive processes unfold over time. To address this limitation, researchers have used hand-tracking techniques to investigate how cognitive processes unfold over the course of a response, are modulated by recent experience, and function across the lifespan. Despite the efficacy of these techniques for investigating a wide range of psychological phenomena, widespread adoption of hand-tracking techniques within the field is hindered by a range of factors, including equipment costs and the use of specialized software. Here, we demonstrate that the behavioral dynamics previously observed with specialized motion-tracking equipment in an Eriksen flanker task can be captured with an affordable, portable, and easy-to-assemble response box. Six-to-eight-year-olds and adults (N = 90) completed a computerized version of the flanker task by pressing and holding a central button until a stimulus array appeared. Participants then responded by releasing the central button and reaching to press one of two response buttons. This method allowed RT to be separated into initiation time (when the central button was released) and movement time (time elapsed between initiation and completion of the response). Consistent with previous research using motion-tracking techniques, initiation times and movement times revealed distinct patterns of effects across trials and between age groups, indicating that the method used in the current study presents a simple solution for researchers from across the psychological and brain sciences looking to move beyond RTs.

Tracking continuities in the flanker task: From continuous flow to movement trajectories.

Since its introduction nearly a half century ago, the Eriksen flanker task has prompted multiple theoretical and methodological advancements in the study of attention and control. Early research with the task inspired the continuous flow model of information processing, which in turn prompted researchers to investigate the dynamics of response competition using continuous behavioral measures. In recent years, the use of such measures in psychological research has increased dramatically as hand-tracking techniques have become more widely accessible. The current article highlights commonly overlooked links between Eriksen and colleagues' pioneering research investigating the continuous flow model and recent hand-tracking research investigating the dynamics of attention and control. After providing an overview of two hand-tracking techniques frequently used in psychological research, we review a series of recent studies that have used these techniques to investigate how the processes underlying attention and control (a) unfold over the course of a response (within-trial dynamics), (b) are impacted by recent experience (cross-trial dynamics), and (c) contribute to age-related changes observed across the life span (developmental dynamics). In addition to highlighting the central role that the flanker task has played in advancing psychological research and theory, this review underscores the advantages of collecting continuous behavioral measures, both in Eriksen's seminal work and in contemporary hand-tracking studies.

Linking the dynamics of cognitive control to individual differences in working memory capacity: Evidence from reaching behavior.

We used a technique known as reach tracking to investigate how individual differences in working memory capacity (WMC) relate to the functioning of two processes proposed to underlie cognitive control: a threshold adjustment process that temporarily inhibits motor output in response to signals of conflict and a controlled selection process that recruits top-down control to guide stimulus-response translation. Undergraduates (N = 135) performed two WMC tasks (updating counters and symmetry span) and a reach-tracking version of the Eriksen flanker task. Consistent with previous research using button-press flanker tasks, WMC significantly correlated with response time (RT) performance, with higher WMC scores corresponding to smaller congruency effects. Given that RTs reflect the combined functioning of multiple processes underlying cognitive control, we interpreted this effect to reflect a general link between WMC and both the threshold adjustment process and controlled selection process. We also found a significant association between WMC and participants' reach trajectories, with higher WMC scores corresponding to more direct reach movements on incongruent trials involving stimulus-response overlap with the preceding trial. We interpreted this effect to reflect a more specific link between WMC and the functioning of the controlled selection process. We discuss the observed links between WMC and cognitive control in relation to the unity and diversity of executive functions framework and in relation to the role of prefrontal and striatal dopamine in supporting adaptive cognitive control. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Tracking the dynamics of global and competitive inhibition in early and late adulthood: Evidence from the flanker task.

Inhibitory control is proposed to involve 2 dissociable processes that feature distinct types of inhibition: a threshold adjustment process involving the global inhibition of motor output and a controlled selection process involving competitive inhibition among coactive responses. Recent research with children and young adults indicates that the functioning of these processes can be targeted by measuring participants' hand movements as they perform inhibitory control tasks by reaching to touch response options on a digital display. The current study explores (a) whether this method can be used to target the functioning of the threshold adjustment process and controlled selection process in adults 65 to 75 years of age and, if so, (b) whether the functioning of each process changes between early and late adulthood. Results from the Eriksen flanker task indicate that reach tracking can be used to target the functioning of each process in late adulthood, with older adults and young adults generating similar patterns of initiation time and curvature effects. The congruency effect observed in response times was significantly larger in older adults than in young adults, indicating that inhibitory control declines in late adulthood. Importantly, this effect was specific to initiation times, suggesting that the threshold adjustment process functions differently in early adulthood than in late adulthood. These results present a new perspective on how age-related differences in inhibitory control are conceptualized and assessed, and raise important questions concerning how the threshold adjustment and controlled selection processes function across a wider range of tasks in late adulthood. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

GWAS SNPs Impact Shared Regulatory Pathways Amongst Multimorbid Psychiatric Disorders and Cognitive Functioning.

Background: Epidemiological research has reported that attention-deficit hyperactivity disorder (ADHD), anxiety, bipolar disorder (BD), schizophrenia (SCZ), and unipolar depression (UD) are multimorbid conditions that are typically accompanied by cognitive advantages or deficits, suggesting that common biological mechanisms may underlie these phenotypes. Genome-wide association studies (GWAS) have identified single-nucleotide polymorphisms (SNPs) associated with psychiatric disorders and cognitive functioning. However, the mechanisms by which these SNPs contribute to multimorbidities amongst psychiatric and cognitive phenotypes remains largely unknown. Objective: To identify shared regulatory mechanisms amongst multimorbid psychiatric disorders and cognitive functioning. Methods: We integrated data on 3D genome organization, expression quantitative trait loci (eQTLs), and pathway analyses to identify shared and specific regulatory impacts of 2,893 GWAS SNPs (p < 1 × 10-6) associated with ADHD, anxiety, BD, SCZ, UD, and cognitive functioning on genes and biological pathways. Drug-gene interaction analysis was performed to identify potential pharmacological impacts on these genes and pathways. Results: The analysis revealed 33 genes and 62 pathways that were commonly affected by tissue-specific gene regulatory interactions associated with all six phenotypes despite there being no common SNPs in our original dataset. The analysis of brain-specific regulatory connections revealed similar patterns at eQTL and eGene levels, but no pathways shared by all six phenotypes. Instead, pairwise overlaps and individualized pathways were identified for psychiatric and cognitive phenotypes in brain tissues. Conclusions: This study offers insight into the shared genes and biological pathways that are affected by tissue-specific regulatory impacts resulting from psychiatric- and cognition-associated genetic variants. These results provide limited support for the "p-factor" hypothesis for psychiatric disorders and potential mechanisms that explain drug side-effects. Our results highlight key biological pathways for development of therapies that target single or multiple psychiatric and cognitive phenotypes.

Layers of latent effects in cognitive control: An EEG investigation.

Recent research demonstrates that two components of reaching behavior - initiation time (the time elapsed from stimulus presentation to movement initiation) and reach curvature (the degree to which a reach movement deviates from a direct path to the selected response) - exhibit distinct cross-trial dynamics in cognitive control tasks, indicating that these components of behavior reflect two dissociable processes underlying cognitive control: a threshold adjustment process involving the inhibition of motor output and a controlled selection process involving the recruitment of top-down resources to support goal-relevant behavior. The current study investigates the extent to which the cross-trial dynamics previously observed in reaching behavior in the Eriksen flanker task are reflected in event-related potentials during standard button-press responses. Candidate EEG measures of the threshold adjustment process (N2 and Pre-LRP amplitudes) failed to reveal the cross-trial dynamics previously observed in initiation times. Slow wave amplitudes exhibited a close correspondence to the cross-trial dynamics observed in reach curvatures, indicating that the measure is sensitive to some functions of the controlled selection process. Further, LRP slopes presented a close correspondence to the cross-trial dynamics observed in response times, indicating that this measure reflects the combined output of the threshold adjustment process and controlled selection process. The implications of these findings for future research examining the links among behavioral and neural dynamics are discussed.

Multiple expectancies underlie the congruency sequence effect in confound-minimized tasks.

The congruency sequence effect (CSE) occurs when the congruency effect observed in tasks such as the Eriksen flanker task is smaller on trials preceded by an incongruent trial relative to trials preceded by a congruent trial. The CSE has been attributed to a range of factors including repetition expectancy, conflict monitoring, feature integration, and contingency learning. To clarify the debate surrounding the CSE and the mechanisms underlying its occurrence, researchers have developed confound-minimized congruency tasks designed to control for feature-integration and contingency-learning effects. A CSE is often observed in confound-minimized tasks, indicating that the effect is driven by repetition expectancy, conflict monitoring, or a combination of the two. Here, we propose and test a variant of the repetition expectancy account that emphasizes how multiple expectations can be formed simultaneously based upon the congruency type (congruent vs. incongruent) and the congruency repetition type (congruency repetition vs. congruency alternation) of the most recent trial. Data from confound-minimized versions of the prime-probe task were found to support this novel account. Data from confound-minimized versions of the Eriksen flanker, Simon, and Stroop tasks indicate that feature-integration confounds often remain in these tasks, potentially undermining the conclusions of previous work. We discuss the implications of these findings for ongoing theoretical debates surrounding the CSE.

Associative priming and conflict differentially affect two processes underlying cognitive control: Evidence from reaching behavior.

Previous research has indicated that two components of reaching behavior, initiation time and reach curvature, exhibit distinct patterns of trial sequence effects in congruency tasks. The observed patterns have been proposed to reflect two dissociable processes underlying decision behavior, with initiation times capturing the functioning of a threshold adjustment process involving the temporary inhibition of motor output, and reach curvatures reflecting a controlled selection process that supports goal-driven stimulus-response translation. The tasks used in previous studies, however, did not control for a range of associative-priming confounds commonly featured in congruency tasks. Consequently, the extent to which the observed patterns reflected the proposed processes or associative-priming confounds remained unclear. We therefore presented 45 adult participants with a reach-tracking version of the Stroop task that featured both confound-minimized and confound-laden trials. Initiation times revealed main effects of previous and current congruency on both confound-minimized and confound-laden trials, consistent with the claim that initiation times can be used to target the functioning of the threshold adjustment process. Conversely, reach curvatures exhibited a clear sensitivity to associative-priming effects, revealing a congruency sequence effect on confound-laden but not on confound-minimized trials. This finding is consistent with the claim that reach curvatures can be used to target the functioning of the controlled selection process. Thus, by directly evaluating the influence of associative-priming confounds, the present study revealed the strongest evidence to date that decision behavior in tasks involving conflict is fundamentally structured by the functioning of two dissociable processes.

Deconstructing the Gratton effect: Targeting dissociable trial sequence effects in children, pre-adolescents, and adults.

The Gratton effect refers to the observation that performance on congruency tasks is often enhanced when the congruency of the current trial matches that of the previous trial. This effect has been at the center of recent debates in the literature on cognitive control as researchers have sought to identify the cognitive and neural underpinnings of the effect. Here, we use a technique known as reach tracking to demonstrate that the Gratton effect originally observed in the flanker task is not a singular effect but the result of two separate trial sequence effects that impact dissociable processes underlying cognitive control. Further, our results indicate that these dissociable processes follow divergent developmental trajectories across childhood, pre-adolescence, and adulthood. Taken together, these findings suggest that manual dynamics can be used to disentangle how key processes underlying cognitive control contribute to the response time effects observed across a wide range of cognitive tasks and age groups.

Cognitive control in action: Tracking the dynamics of rule switching in 5- to 8-year-olds and adults.

Recent studies have suggested that dissociable processes featuring distinct types of inhibition support cognitive control in tasks requiring participants to override a prepotent response with a control-demanding alternative response. An open question concerns how these processes support cognitive flexibility in rule-switching tasks. We used a technique known as reach tracking to investigate how 5- to 8-year-olds (Experiment 1) and adults (Experiment 2) select, maintain, and switch between incompatible rule sets in a computerized version of the Dimensional Change Card Sort (DCCS). Our results indicate that rule switching differentially impacts two key processes underlying cognitive control in children and adults. Adult performance also revealed a strong response bias not observed in children, which complicated a direct comparison of switching between the age groups and reopens questions concerning the relation between child and adult performance on the task. We discuss these findings in the context of a contemporary model of cognitive control.

Reach tracking reveals dissociable processes underlying cognitive control.

The current study uses reach tracking to investigate how cognitive control is implemented during online performance of the Stroop task (Experiment 1) and the Eriksen flanker task (Experiment 2). We demonstrate that two of the measures afforded by reach tracking, initiation time and reach curvature, capture distinct patterns of effects that have been linked to dissociable processes underlying cognitive control in electrophysiology and functional neuroimaging research. Our results suggest that initiation time reflects a response threshold adjustment process involving the inhibition of motor output, while reach curvature reflects the degree of co-activation between response alternatives registered by a monitoring process over the course of a trial. In addition to shedding new light on fundamental questions concerning how these processes contribute to the cognitive control of behavior, these results present a framework for future research to investigate how these processes function across different tasks, develop across the lifespan, and differ among individuals.

Surveillance Practice Patterns after Curative Intent Therapy for Stage I Non-Small-Cell Lung Cancer in the Medicare Population.

OBJECTIVES: Recurrence after treatment for non-small cell lung cancer (NSCLC) is common, and routine imaging surveillance is recommended by evidence-based guidelines. Little is known about surveillance patterns after curative intent therapy for early stage NSCLC. We sought to understand recent practice patterns for surveillance of stage I NSCLC in the first two years after curative intent therapy in the Medicare population. MATERIALS AND METHODS: Using the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database we selected patients diagnosed with stage I NSCLC between 1998 and 2008. We studied adherence to surveillance guidelines based on specialty society recommendations for chest radiography and computed tomography (CT) scanning. We also tracked the use of Positron Emission Tomography (PET) scans, which are not recommended for surveillance. We calculated the percent of patients who received guideline-adherent surveillance imaging and used logistic regression to determine associations between patient and provider factors and guideline adherence. RESULTS: Overall, 61.4% of patients received guideline-adherent surveillance during the initial 2 years after treatment. Use of CT scans in the first year after treatment increased from 47.4% in 1998-78.5% in 2008, and PET use increased from 5.8% to 28.9%. Adherence with surveillance imaging was associated with younger age, higher income, more comorbidities, access to primary care, and receipt of SBRT as the primary treatment. CONCLUSIONS: Adherence to specialty society guidelines for surveillance after treatment for stage I NSCLC was poor in this population of Medicare beneficiaries, with less than two-thirds of patients receiving recommended imaging, and almost 30% receiving non-recommended PET scans.

The development of diagnostic reasoning about uncertain events between ages 4-7.

The present investigation examines the development of children's diagnostic reasoning abilities when such inferences involve belief revision about uncertain potential causes. Four- to 7-year-olds observed an event occur that was due to one of four potential causes. Some of those potential causes were revealed to be efficacious; others were revealed to be inefficacious, but there was always one potential cause presented with unknown efficacy. While all children could make appropriate predictive inferences about this situation, 4- and 5-year-olds were less capable of making correct diagnostic inferences about the cause of the event under these circumstances than older children. We discuss possible mechanisms for this development, as well as speculate on the relation between these findings and literature in children's scientific reasoning.