Pesquisa | BVS Violência e Saúde

1.

Inherited blood cancer predisposition through altered transcription elongation.

Zhao, Jiawei; Cato, Liam D; Arora, Uma P; Bao, Erik L; Bryant, Samuel C; Williams, Nicholas; Jia, Yuemeng; Goldman, Seth R; Nangalia, Jyoti; Erb, Michael A; Vos, Seychelle M; Armstrong, Scott A; Sankaran, Vijay G.

Cell ; 187(3): 642-658.e19, 2024 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-38218188

2.

Acetyl-CoA biosynthesis drives resistance to histone acetyltransferase inhibition.

Bishop, Timothy R; Subramanian, Chitra; Bilotta, Eric M; Garnar-Wortzel, Leopold; Ramos, Anissa R; Zhang, Yuxiang; Asiaban, Joshua N; Ott, Christopher J; Rock, Charles O; Erb, Michael A.

Nat Chem Biol ; 19(10): 1215-1222, 2023 10.

Artigo em Inglês | MEDLINE | ID: mdl-37127754

3.

BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment.

Winter, Georg E; Mayer, Andreas; Buckley, Dennis L; Erb, Michael A; Roderick, Justine E; Vittori, Sarah; Reyes, Jaime M; di Iulio, Julia; Souza, Amanda; Ott, Christopher J; Roberts, Justin M; Zeid, Rhamy; Scott, Thomas G; Paulk, Joshiawa; Lachance, Kate; Olson, Calla M; Dastjerdi, Shiva; Bauer, Sophie; Lin, Charles Y; Gray, Nathanael S; Kelliher, Michelle A; Churchman, L Stirling; Bradner, James E.

Mol Cell ; 67(1): 5-18.e19, 2017 Jul 06.

Artigo em Inglês | MEDLINE | ID: mdl-28673542

4.

SuFEx-based chemical diversification for the systematic discovery of CRBN molecular glues.

Carter, Trever R; Milosevich, Natalia; Dada, Lucas; Shaum, James B; Barry Sharpless, K; Kitamura, Seiya; Erb, Michael A.

Bioorg Med Chem ; 104: 117699, 2024 Apr 15.

Artigo em Inglês | MEDLINE | ID: mdl-38608634

5.

A short ORF-encoded transcriptional regulator.

Koh, Minseob; Ahmad, Insha; Ko, Yeonjin; Zhang, Yuxiang; Martinez, Thomas F; Diedrich, Jolene K; Chu, Qian; Moresco, James J; Erb, Michael A; Saghatelian, Alan; Schultz, Peter G; Bollong, Michael J.

Proc Natl Acad Sci U S A ; 118(4)2021 01 26.

Artigo em Inglês | MEDLINE | ID: mdl-33468658

6.

Transcription control by the ENL YEATS domain in acute leukaemia.

Erb, Michael A; Scott, Thomas G; Li, Bin E; Xie, Huafeng; Paulk, Joshiawa; Seo, Hyuk-Soo; Souza, Amanda; Roberts, Justin M; Dastjerdi, Shiva; Buckley, Dennis L; Sanjana, Neville E; Shalem, Ophir; Nabet, Behnam; Zeid, Rhamy; Offei-Addo, Nana K; Dhe-Paganon, Sirano; Zhang, Feng; Orkin, Stuart H; Winter, Georg E; Bradner, James E.

Nature ; 543(7644): 270-274, 2017 03 09.

Artigo em Inglês | MEDLINE | ID: mdl-28241139

7.

ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia.

Wan, Liling; Wen, Hong; Li, Yuanyuan; Lyu, Jie; Xi, Yuanxin; Hoshii, Takayuki; Joseph, Julia K; Wang, Xiaolu; Loh, Yong-Hwee E; Erb, Michael A; Souza, Amanda L; Bradner, James E; Shen, Li; Li, Wei; Li, Haitao; Allis, C David; Armstrong, Scott A; Shi, Xiaobing.

Nature ; 543(7644): 265-269, 2017 03 09.

Artigo em Inglês | MEDLINE | ID: mdl-28241141

8.

Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.

Olson, Calla M; Jiang, Baishan; Erb, Michael A; Liang, Yanke; Doctor, Zainab M; Zhang, Zinan; Zhang, Tinghu; Kwiatkowski, Nicholas; Boukhali, Myriam; Green, Jennifer L; Haas, Wilhelm; Nomanbhoy, Tyzoon; Fischer, Eric S; Young, Richard A; Bradner, James E; Winter, Georg E; Gray, Nathanael S.

Nat Chem Biol ; 14(2): 163-170, 2018 02.

Artigo em Inglês | MEDLINE | ID: mdl-29251720

9.

The dTAG system for immediate and target-specific protein degradation.

Nabet, Behnam; Roberts, Justin M; Buckley, Dennis L; Paulk, Joshiawa; Dastjerdi, Shiva; Yang, Annan; Leggett, Alan L; Erb, Michael A; Lawlor, Matthew A; Souza, Amanda; Scott, Thomas G; Vittori, Sarah; Perry, Jennifer A; Qi, Jun; Winter, Georg E; Wong, Kwok-Kin; Gray, Nathanael S; Bradner, James E.

Nat Chem Biol ; 14(5): 431-441, 2018 05.

Artigo em Inglês | MEDLINE | ID: mdl-29581585

10.

Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands.

Gechijian, Lara N; Buckley, Dennis L; Lawlor, Matthew A; Reyes, Jaime M; Paulk, Joshiawa; Ott, Christopher J; Winter, Georg E; Erb, Michael A; Scott, Thomas G; Xu, Mousheng; Seo, Hyuk-Soo; Dhe-Paganon, Sirano; Kwiatkowski, Nicholas P; Perry, Jennifer A; Qi, Jun; Gray, Nathanael S; Bradner, James E.

Nat Chem Biol ; 14(4): 405-412, 2018 04.

Artigo em Inglês | MEDLINE | ID: mdl-29507391

11.

Processing for destruction.

Erb, Michael A.

Nat Chem Biol ; 16(1): 3-4, 2020 01.

Artigo em Inglês | MEDLINE | ID: mdl-31819275

12.

Redirecting the pioneering function of FOXA1 with covalent small molecules.

Won, Sang Joon; Zhang, Yuxiang; Reinhardt, Christopher J; MacRae, Nicole S; DeMeester, Kristen E; Njomen, Evert; Hargis, Lauren M; Remsberg, Jarrett R; Melillo, Bruno; Cravatt, Benjamin F; Erb, Michael A.

bioRxiv ; 2024 Mar 21.

Artigo em Inglês | MEDLINE | ID: mdl-38562719

13.

Small-molecule tools for YEATS domain proteins.

Erb, Michael A.

Curr Opin Chem Biol ; 77: 102404, 2023 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-37924571

14.

Collateral lethality between HDAC1 and HDAC2 exploits cancer-specific NuRD complex vulnerabilities.

Zhang, Yuxiang; Remillard, David; Onubogu, Ugoma; Karakyriakou, Barbara; Asiaban, Joshua N; Ramos, Anissa R; Bowland, Kirsten; Bishop, Timothy R; Barta, Paige A; Nance, Stephanie; Durbin, Adam D; Ott, Christopher J; Janiszewska, Michalina; Cravatt, Benjamin F; Erb, Michael A.

Nat Struct Mol Biol ; 30(8): 1160-1171, 2023 08.

Artigo em Inglês | MEDLINE | ID: mdl-37488358

15.

Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia.

Garnar-Wortzel, Leopold; Bishop, Timothy R; Kitamura, Seiya; Milosevich, Natalia; Asiaban, Joshua N; Zhang, Xiaoyu; Zheng, Qinheng; Chen, Emily; Ramos, Anissa R; Ackerman, Christopher J; Hampton, Eric N; Chatterjee, Arnab K; Young, Travis S; Hull, Mitchell V; Sharpless, K Barry; Cravatt, Benjamin F; Wolan, Dennis W; Erb, Michael A.

ACS Cent Sci ; 7(5): 815-830, 2021 May 26.

Artigo em Inglês | MEDLINE | ID: mdl-34079898

16.

Cell-Based Ligand Discovery for the ENL YEATS Domain.

Asiaban, Joshua N; Milosevich, Natalia; Chen, Emily; Bishop, Timothy R; Wang, Justin; Zhang, Yuxiang; Ackerman, Christopher J; Hampton, Eric N; Young, Travis S; Hull, Mitchell V; Cravatt, Benjamin F; Erb, Michael A.

ACS Chem Biol ; 15(4): 895-903, 2020 04 17.

Artigo em Inglês | MEDLINE | ID: mdl-32176478

17.

Pharmacological Modulation of Transcriptional Coregulators in Cancer.

Bishop, Timothy R; Zhang, Yuxiang; Erb, Michael A.

Trends Pharmacol Sci ; 40(6): 388-402, 2019 06.

Artigo em Inglês | MEDLINE | ID: mdl-31078321

18.

Translation Termination Factor GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide Degraders.

Ishoey, Mette; Chorn, Someth; Singh, Natesh; Jaeger, Martin G; Brand, Matthias; Paulk, Joshiawa; Bauer, Sophie; Erb, Michael A; Parapatics, Katja; Müller, André C; Bennett, Keiryn L; Ecker, Gerhard F; Bradner, James E; Winter, Georg E.

ACS Chem Biol ; 13(3): 553-560, 2018 03 16.

Artigo em Inglês | MEDLINE | ID: mdl-29356495

19.

Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma.

Zeid, Rhamy; Lawlor, Matthew A; Poon, Evon; Reyes, Jaime M; Fulciniti, Mariateresa; Lopez, Michael A; Scott, Thomas G; Nabet, Behnam; Erb, Michael A; Winter, Georg E; Jacobson, Zoe; Polaski, Donald R; Karlin, Kristen L; Hirsch, Rachel A; Munshi, Nikhil P; Westbrook, Thomas F; Chesler, Louis; Lin, Charles Y; Bradner, James E.

Nat Genet ; 50(4): 515-523, 2018 04.

Artigo em Inglês | MEDLINE | ID: mdl-29379199

20.

Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1.

Daniels-Wells, Tracy R; Helguera, Gustavo; Rodríguez, José A; Leoh, Lai Sum; Erb, Michael A; Diamante, Graciel; Casero, David; Pellegrini, Matteo; Martínez-Maza, Otoniel; Penichet, Manuel L.

Toxicol In Vitro ; 27(1): 220-31, 2013 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-23085102

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