Detalhe da pesquisa
1.
Deleterious, protein-altering variants in the transcriptional coregulator ZMYM3 in 27 individuals with a neurodevelopmental delay phenotype.
Am J Hum Genet
; 110(2): 215-227, 2023 02 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36586412
2.
Ionization and lipophilicity in nonpolar media mimicking the cell membrane interior.
Bioorg Med Chem
; 81: 117203, 2023 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36796127
3.
In Silico Tools to Extract the Drug Design Information Content of Degradation Data: The Case of PROTACs Targeting the Androgen Receptor.
Molecules
; 28(3)2023 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36770875
4.
Personalized Treatment for Infantile Ascending Hereditary Spastic Paralysis Based on In Silico Strategies.
Molecules
; 27(20)2022 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36296656
5.
Managing Experimental 3D Structures in the Beyond-Rule-of-5 Chemical Space: The Case of Rifampicin.
Chemistry
; 27(40): 10394-10404, 2021 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34114271
6.
PROTACs and Building Blocks: The 2D Chemical Space in Very Early Drug Discovery.
Molecules
; 26(3)2021 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33525371
7.
Intramolecular hydrogen bonding: An opportunity for improved design in medicinal chemistry.
Med Res Rev
; 39(5): 1707-1729, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30659634
8.
Log P as a tool in intramolecular hydrogen bond considerations.
Drug Discov Today Technol
; 27: 65-70, 2018 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-30103865
9.
Relationship between Passive Permeability and Molecular Polarity Using Block Relevance Analysis.
Mol Pharm
; 14(2): 386-393, 2017 02 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28035823
10.
A Fast Chromatographic Method for Estimating Lipophilicity and Ionization in Nonpolar Membrane-Like Environment.
Mol Pharm
; 13(3): 1100-10, 2016 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26767433
11.
Multivariate analysis applied to Raman mapping of dye-functionalized carbon nanotubes: a novel approach to support the rational design of functional nanostructures.
Analyst
; 140(16): 5754-63, 2015 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26167770
12.
Prediction and interpretation of the lipophilicity of small peptides.
J Comput Aided Mol Des
; 29(4): 361-70, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25577035
13.
DegraderTCM: A Computationally Sparing Approach for Predicting Ternary Degradation Complexes.
ACS Med Chem Lett
; 15(1): 45-53, 2024 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38229751
14.
Exploring the chemical space of orally bioavailable PROTACs.
Drug Discov Today
; 29(4): 103917, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38360147
15.
The Quest for Oral PROTAC drugs: Evaluating the Weaknesses of the Screening Pipeline.
ACS Med Chem Lett
; 14(7): 879-883, 2023 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37465314
16.
Conformational Sampling Deciphers the Chameleonic Properties of a VHL-Based Degrader.
Pharmaceutics
; 15(1)2023 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36678900
17.
High-throughput and reliable assessments of the ionization constant of monoprotic organic acids through an arginine based mixed mode HPLC.
J Pharm Biomed Anal
; 235: 115604, 2023 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37531733
18.
Chamelogk: A Chromatographic Chameleonicity Quantifier to Design Orally Bioavailable Beyond-Rule-of-5 Drugs.
J Med Chem
; 66(15): 10681-10693, 2023 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37490408
19.
AI-based protein structure databases have the potential to accelerate rare diseases research: AlphaFoldDB and the case of IAHSP/Alsin.
Drug Discov Today
; 27(6): 1652-1660, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34958957
20.
Application of the anthraquinone drug rhein as an axial ligand in bifunctional Pt(IV) complexes to obtain antiproliferative agents against human glioblastoma cells.
Dalton Trans
; 51(15): 6014-6026, 2022 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35352739