Detalhe da pesquisa
1.
A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria.
Nature
; 520(7549): 683-7, 2015 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-25874676
2.
Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma.
Proc Natl Acad Sci U S A
; 113(46): 13162-13167, 2016 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27799547
3.
Design and synthesis of a crosslinker for studying intracellular steroid trafficking pathways.
Bioorg Med Chem
; 23(13): 3843-51, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25890696
4.
Characterization of the Anopheles gambiae octopamine receptor and discovery of potential agonists and antagonists using a combined computational-experimental approach.
Malar J
; 13: 434, 2014 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-25407998
5.
Computational studies of the cholesterol transport between NPC2 and the N-terminal domain of NPC1 (NPC1(NTD)).
Biochemistry
; 52(39): 6879-91, 2013 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24001314
6.
Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs.
Bioorg Med Chem Lett
; 23(21): 6025-8, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24035339
7.
Inhibition pattern of sulfamide-related compounds in binding to carbonic anhydrase isoforms I, II, VII, XII and XIV.
Bioorg Med Chem
; 21(6): 1410-8, 2013 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23266178
8.
Affinity of sulfamates and sulfamides to carbonic anhydrase II isoform: experimental and molecular modeling approaches.
J Chem Inf Model
; 50(6): 1113-22, 2010 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20481572
9.
On the inhibition of histone deacetylase 8.
Bioorg Med Chem
; 18(11): 4103-10, 2010 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20472442
10.
Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole.
J Am Chem Soc
; 131(8): 2900-5, 2009 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-19193120
11.
Structural origin of selectivity in class II-selective histone deacetylase inhibitors.
J Med Chem
; 51(10): 2898-906, 2008 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-18412327
12.
The hydrolysis of amides and the proficiency of amidohydrolases. The burden borne by kw.
J Phys Chem B
; 111(23): 6507-19, 2007 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17508734
13.
Competitive hydrolytic and elimination mechanisms in the urease catalyzed decomposition of urea.
J Phys Chem B
; 111(34): 10263-74, 2007 Aug 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-17676790
14.
The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.
Sci Transl Med
; 7(288): 288ra77, 2015 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25995223
15.
Docking applied to the prediction of the affinity of compounds to P-glycoprotein.
Biomed Res Int
; 2014: 358425, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24982867
16.
Identifying ligand binding conformations of the ß2-adrenergic receptor by using its agonists as computational probes.
PLoS One
; 7(12): e50186, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23300522
17.
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.
Nat Commun
; 3: 1288, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23250418
18.
Synthesis and modeling of new benzofuranone histone deacetylase inhibitors that stimulate tumor suppressor gene expression.
J Med Chem
; 52(9): 3112-5, 2009 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19385600
19.
Synthesis and anticonvulsant activity of amino acid-derived sulfamides.
J Med Chem
; 52(6): 1592-601, 2009 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-19249853
20.
Residues in the 11 A channel of histone deacetylase 1 promote catalytic activity: implications for designing isoform-selective histone deacetylase inhibitors.
J Med Chem
; 51(18): 5542-51, 2008 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-18729444