RESUMO
AIDS: HIV infection is associated with a number of blood abnormalities. Anemia is a frequent consequence, affecting 15 percent of asymptomatic HIV-positive individuals and 85 percent of those with AIDS. Anemia is defined by a decreased number of red blood cells. Individuals with anemia have a diminished capacity to carry oxygen in their blood and suffer from fatigue, difficulty breathing, increased heart rate, pallor, and occasionally heart murmurs. Treatment depends on the underlying cause of anemia.^ieng
Assuntos
Anemia/etiologia , Eritropoese/fisiologia , Infecções por HIV/complicações , Anemia/diagnóstico , Anemia/imunologia , Fármacos Anti-HIV/efeitos adversos , Medula Óssea/fisiologia , Eritropoese/efeitos dos fármacos , Eritropoetina/uso terapêutico , Humanos , Rim/fisiologia , Proteínas Recombinantes , Zidovudina/efeitos adversosRESUMO
The hypothesis that a global defect in cellular calcium transport may be critical in the development of familial benign hypercalcaemia (FBH) was investigated. Nine hypercalcaemic patients from a kindred with FBH and nine normal subjects were evaluated. Our results indicate that calcium pump activity in the FBH kindred was significantly higher (28%, P < 0.005) when compared to normal subjects. These findings suggest that alterations in calcium pump activity in target tissues may play a role in the development of FBH.