Detalhe da pesquisa
1.
HDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutations.
EMBO J
; 40(7): e106177, 2021 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33694180
2.
Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration.
Alzheimers Dement
; 14(10): 1261-1280, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30036493
3.
A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons.
Acta Neuropathol Commun
; 11(1): 151, 2023 09 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37723585
4.
C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility.
Sci Adv
; 7(15)2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33837088
5.
Differentiation but not ALS mutations in FUS rewires motor neuron metabolism.
Nat Commun
; 10(1): 4147, 2019 09 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31515480
6.
Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice.
Mol Neurodegener
; 13(1): 55, 2018 10 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30326935