RESUMO
Mice exposed to surgical stress induced by laparotomy and treated with chronic alprazolam (0.5-2 mg/kg) showed a dose-dependent reduction in stress-induced suppression of the natural killer (NK) cell activity. These immunoenhancing effects of alprazolam were more intense when it administered before the surgery was performed.
Assuntos
Alprazolam/farmacologia , Células Matadoras Naturais/efeitos dos fármacos , Estresse Fisiológico/imunologia , Animais , Formação de Anticorpos/efeitos dos fármacos , Relação Dose-Resposta a Droga , Células Matadoras Naturais/imunologia , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Estresse Fisiológico/tratamento farmacológico , Estresse Fisiológico/etiologia , Procedimentos Cirúrgicos Operatórios/efeitos adversosRESUMO
Experiments were conducted to evaluate the effects of amphetamine (0. 4 mg/kg) on the development of autochthonous tumors induced by the Moloney sarcoma virus (MSV) in Balb/c female mice. Enhancement of MSV-induced tumor incidence and tumor growth was observed, together with a delay in the usual prompt regression of the tumors, when mice were daily injected with amphetamine for 3 days after MSV-inoculation. However, no effects of amphetamine on tumor development were observed when it was administered during the 3 days before tumor inoculation.
Assuntos
Adrenérgicos/farmacologia , Anfetamina/farmacologia , Vírus do Sarcoma Murino de Moloney , Infecções por Retroviridae/patologia , Sarcoma Experimental/patologia , Infecções Tumorais por Vírus/patologia , Animais , Feminino , Imunidade Celular/efeitos dos fármacos , Injeções Subcutâneas , Camundongos , Camundongos Endogâmicos BALB C , Pré-Medicação , Infecções por Retroviridae/tratamento farmacológico , Sarcoma Experimental/tratamento farmacológico , Infecções Tumorais por Vírus/tratamento farmacológicoRESUMO
Experiments were conducted to evaluate the influences of chronic treatment with amphetamine (0.4 mg/kg/day) on the activity of phagocytosis in mice. Results show a decrease of the in vitro and in vivo phagocytosis measured by using the zymosan-particle uptake method and the carbon clearance test, respectively.
Assuntos
Anfetamina/farmacologia , Fagocitose/efeitos dos fármacos , Animais , Feminino , Macrófagos/efeitos dos fármacos , Macrófagos/imunologia , Camundongos , Camundongos Endogâmicos BALB C , Cavidade Peritoneal/citologia , Fatores de TempoRESUMO
Several experiments were conducted to evaluate the effects of chronic amphetamine on the influenza A (PR-8/34) virus specific immune injury in CD-1 mice. Treatment with amphetamine resulted in a significant increase of lung virus titers and pulmonary vascular permeability. Amphetamine also increased the lethality of infected mice.
Assuntos
Anfetamina/farmacologia , Infecções por Orthomyxoviridae/tratamento farmacológico , Orthomyxoviridae/efeitos dos fármacos , Animais , Pulmão/microbiologia , Masculino , Camundongos , Camundongos Endogâmicos , Orthomyxoviridae/patogenicidade , Distribuição AleatóriaRESUMO
Mice chronically injected with amphetamine (0.4 mg/kg/day) showed a reduction in thymus and spleen cellularity, and in peripheral T lymphocyte population. The blastogenic response of spleen lymphoid cells was assessed and amphetamine was found to inhibit T-cell proliferation. Amphetamine also reduced the capacity of mice to the development and passive transfer of immunity to Listeria monocytogenes.
Assuntos
Anfetamina/farmacologia , Linfócitos T/efeitos dos fármacos , Animais , Feminino , Imunoterapia Adotiva , Contagem de Leucócitos/efeitos dos fármacos , Listeria monocytogenes/imunologia , Ativação Linfocitária/efeitos dos fármacos , Camundongos , Camundongos Endogâmicos C57BL , Baço/imunologia , Linfócitos T/imunologia , Timo/imunologiaRESUMO
Experiments were performed in order to evaluate the effects of fluoxetine, a selective inhibitor of neural serotonin transporter antidepressant, on the development lung metastases in rats subjected to laparotomy and injected (i.v.) with 10(4) Walker 256 (W-256) carcinosarcoma cells. The number of metastatic nodules on the surface of the lungs, as well as the percentage-area of metastases in the frontal section through pulmonary hilus were increased in rats subjected to sham-surgery or laparotomy. Treatment with fluoxetine (5 mg/kg) partially reversed those adverse effects of surgery, but the difference was clearer when it was administered before surgery was performed. Survival periods were also assessed and fluoxetine was found to decrease the lethality of rats exposed to surgery.
Assuntos
Antidepressivos de Segunda Geração/farmacologia , Antineoplásicos/farmacologia , Carcinoma 256 de Walker/tratamento farmacológico , Carcinoma 256 de Walker/secundário , Fluoxetina/farmacologia , Neoplasias Pulmonares/tratamento farmacológico , Neoplasias Pulmonares/secundário , Inibidores Seletivos de Recaptação de Serotonina/farmacologia , Estresse Fisiológico/complicações , Procedimentos Cirúrgicos Operatórios/efeitos adversos , Animais , Masculino , Transplante de Neoplasias , Ratos , Ratos Sprague-Dawley , Estresse Fisiológico/etiologiaRESUMO
The review of the literature shows that stress can adversely affect influenza A virus infection. In this report, we study the effects of chronic alprazolam (1 mg/kg/day), a central benzodiazepine agonist anxiolytic, on the influenza A (PR-8/34) virus specific immune injury in mice exposed to a chronic auditory stressor. Treatment with alprazolam resulted in a significant reduction of stress-induced increase of virus titters and pulmonary vascular permeability. A correlation with the lethality of mice was also observed.
Assuntos
Alprazolam/farmacologia , Vírus da Influenza A , Infecções por Orthomyxoviridae/psicologia , Estresse Psicológico/psicologia , Estimulação Acústica/efeitos adversos , Animais , Permeabilidade Capilar/fisiologia , Vírus da Influenza A/patogenicidade , Pulmão/microbiologia , Masculino , Camundongos , Infecções por Orthomyxoviridae/complicações , Infecções por Orthomyxoviridae/mortalidade , Alvéolos Pulmonares/fisiopatologia , Estresse Psicológico/complicações , Estresse Psicológico/mortalidade , Taxa de SobrevidaRESUMO
Several experiments were conducted to evaluate the effects of buspirone, a selective 5-hydroxytryptamine-1A (5-HT1A) anxiolytic, on the immune system of mice exposed to a chronic auditory stressor. Daily injection with 0.5 and 1 mg/kg (intraperitoneally) of buspirone resulted in a dose-dependent reduction in the stress-induced suppression of the natural killer (NK) cell activity and the in vitro and in vivo activity of phagocytosis. Higher doses of buspirone (2.0 mg/kg) showed less robust immunoenhancing effects in stressed mice, and caused a significant suppression of these immune parameters in unstressed mice.
Assuntos
Buspirona/farmacologia , Imunidade/efeitos dos fármacos , Estresse Psicológico/imunologia , Animais , Relação Dose-Resposta a Droga , Técnicas In Vitro , Células Matadoras Naturais/efeitos dos fármacos , Macrófagos/efeitos dos fármacos , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Ruído/efeitos adversos , Fagocitose/efeitos dos fármacos , Baço/citologia , Baço/efeitos dos fármacosRESUMO
Mice exposed to a chronic auditory stressor and treated chronically with buspirone (1 mg/kg) showed a reduction in stress-induced suppression of the resistance and development of immunity to Listeria monocytogenes. Attempts to passively transfer immunity with spleen cells were also performed. Stressed, immunized mice had a reduced capacity to transfer immunity passively to nonimmunized mice and buspirone was found to partially suppress this inhibitory effect of stress.
Assuntos
Buspirona/farmacologia , Listeria monocytogenes/imunologia , Listeriose/imunologia , Estresse Fisiológico/imunologia , Animais , Feminino , Imunidade/efeitos dos fármacos , Imunização Passiva , Listeriose/etiologia , Listeriose/prevenção & controle , Fígado/imunologia , Fígado/microbiologia , Camundongos , Camundongos Endogâmicos C57BL , Baço/imunologia , Baço/microbiologia , Estresse Fisiológico/fisiopatologiaRESUMO
Mice exposed to a chronic auditory stressor and daily injected with alprazolam (1 mg/kg/day, s.c.) showed a reduction in stress-induced suppression of the in vitro and in vivo activity of phagocytosis, measured using the zymosan particle uptake method and the carbon clearance test, respectively. Pretreatment with Ro-15-1788 (10 mg/kg, s.c.), a central nervous system benzodiazepine antagonist, resulted in suppression of the effects of alprazolam in stressed mice.
Assuntos
Alprazolam/uso terapêutico , Ruído/efeitos adversos , Fagocitose , Estresse Fisiológico/imunologia , Alprazolam/antagonistas & inibidores , Alprazolam/farmacologia , Animais , Carbono , Feminino , Flumazenil/farmacologia , Macrófagos Peritoneais/efeitos dos fármacos , Camundongos , Camundongos Endogâmicos BALB C , Fagocitose/efeitos dos fármacos , Estresse Fisiológico/tratamento farmacológico , ZimosanRESUMO
Experiments were conducted to evaluate the effects of alprazolam (1 mg/kg i.p.) on the development of autochthonous tumors induced by the Moloney sarcoma virus (MSV) in BALB/c female mice subjected to stress. Enhancement of MSV-induced tumor incidence and growth was observed, together with a delay in the usual prompt regression of the tumors, when programmed white sound anxiety-stress was administered immediately following MSV i.m. inoculation. However, a depressant effect on tumor size and incidence was observed when stress was administered before virus inoculation. Treatment with alprazolam was found to reverse partially the adverse effects of postinoculation stress, and also to inhibit the beneficial effects of the preinoculation administration of stress on tumor development. Pretreatment with Ro 15-1788 (10 mg/kg s.c.), a central benzodiazepine antagonist, resulted in a suppression on both effects of alprazolam in stressed mice.