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1.
Neurol Sci ; 40(11): 2343-2348, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31250281

RESUMO

BACKGROUND: Cognitive profile in migraine patients still remains undefined. Contradictory evidence has been provided, with impairments in different cognitive domains, normal cognition, or even better performance compared to healthy controls (HC). The latter is of particular interest considering the evidence of glutamatergic upregulation in migraine, particularly in the visual cortex, and the role of the glutamatergic system in synaptic plasticity and learning. The aim of our study is to compare cognitive performance for visuospatial memory and learning (supraspan modality) between migraineurs without aura (MwoA) and HC. METHODS: Twenty-one subjects suffering from MwoA and 21 HC were enrolled. Migraineurs during the interictal phase and HC underwent visuospatial memory test (Corsi test) and verbal memory test (Buschke Selective Reminding Test) in supraspan modality, Trial Making Test A (TMTA) and B (TMTB) as test exploring attention, and TMTB-TMTA as test of executive functioning. Depression was assessed with the Beck Depression Inventory Short Form (BDI-SF). Migraine characteristics (i.e., disease duration and frequency expressed as attacks per month) were collected. RESULTS: Subjects with MwoA showed better performance than HC in test exploring both short (p = 0.002) and long-term (p = 0.001) visuospatial memory. No significant difference between groups was found in verbal memory, attention, executive functioning, and depression (BDI-SF). No significant association emerged between cognitive performance and migraine characteristics. DISCUSSION: Subjects with MwoA had significant better performance in visuospatial memory and learning than HC. Occipito-parietal hyperexcitability (in particular in the visual cortex), which is a hallmark of the migraine brain, would probably explain these results. These data need to be confirmed in larger samples of migraineurs.


Assuntos
Memória/fisiologia , Enxaqueca sem Aura/fisiopatologia , Aprendizagem Espacial/fisiologia , Percepção Visual/fisiologia , Adulto , Atenção/fisiologia , Função Executiva/fisiologia , Feminino , Humanos , Masculino , Memória de Longo Prazo/fisiologia , Memória de Curto Prazo/fisiologia , Memória Espacial/fisiologia , Córtex Visual/fisiopatologia
2.
Neurol Sci ; 39(8): 1471-1473, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-29756180

RESUMO

Swallowing difficulties are a common symptom of multiple sclerosis (MS). The early detection and treatment of dysphagia is critical to prevent complications, including poor nutrition, dehydration, and lung infections. Recently, transcranial direct current stimulation (tDCS) has been proven to be effective in ameliorating swallowing problems in stroke patients. In this pilot study, we aimed to assess safety and efficacy of transcranial direct current stimulation (tDCS) in the treatment of dysphagia in MS patients. We screened 30 patients by using the 10-item DYsphagia in MUltiple Sclerosis (DYMUS) questionnaire, and patients at risk for dysphagia underwent a clinical and fiberoptic endoscopic evaluation of swallowing (FEES). Six patients who presented with mild to moderate dysphagia underwent the experimental procedures. These consisted of 5 sessions of anodal tDCS applied in consecutive days over the right swallowing motor cortex. Patients were followed-up at 1 week, 1 month and 3 months after treatment, and changes in the Dysphagia Outcome and Severity Scale (DOSS) score between baseline and post-tDCS were assessed. Our results showed that in all patients, the tDCS treatment determined a mild but significant clinical benefit (one-point improvement in the DOSS score) lasting up to 1 month. In conclusion, our preliminary results show that anodal tDCS has therapeutic potential in the treatment of swallowing problems in patients suffering with MS. However, future double-blind, randomized, and sham-controlled studies are needed to confirm the present findings.


Assuntos
Transtornos de Deglutição/etiologia , Transtornos de Deglutição/terapia , Córtex Motor/fisiologia , Esclerose Múltipla/complicações , Estimulação Transcraniana por Corrente Contínua/métodos , Adulto , Eletrodos , Eletromiografia , Potencial Evocado Motor/fisiologia , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Projetos Piloto , Índice de Gravidade de Doença , Resultado do Tratamento
3.
Exp Brain Res ; 212(1): 101-7, 2011 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-21537965

RESUMO

Habituation, i.e. the decremental response to repeated sensorial stimulation, is studied in humans through evoked potential stimulation. Mechanisms underlying habituation are not yet cleared, even if inhibitory circuits are supposed to play an important role. Light deprivation (LD) increases visual cortical excitability likely through down-regulation of GABA circuits. We previously found that high-frequency repetitive transcranial magnetic stimulation (hf-rTMS) can revert these facilitatory effects likely restoring the activity of inhibitory circuits. Here, we studied the effects of LD and rTMS on habituation of visual evoked potentials (VEPs). The hypothesis was that if the inhibitory circuits have a role in habituation, then LD that downregulates GABA circuits, should impair habituation that in turn should be restored by hf-rTMS. Fifteen healthy subjects underwent VEPs recording in baseline (without LD), in LD alone (without rTMS), in LD and 1 Hz rTMS and in LD and 10 Hz rTMS. Habituation observed in baseline (without LD) was significantly impaired after LD; 10 Hz but not 1 Hz rTMS was able to restore normal habituation phenomena. VEPs habituation is impaired by LD but it could be restored if hf-rTMS is given during LD. As LD acts reducing GABA circuits activity and hf-rTMS likely upregulates such circuits, these data give support to the hypothesis that cortical inhibition can play a relevant role in mechanisms underlying habituation.


Assuntos
Escuridão , Potenciais Evocados Visuais/fisiologia , Habituação Psicofisiológica/fisiologia , Inibição Neural/fisiologia , Estimulação Magnética Transcraniana/métodos , Córtex Visual/fisiologia , Adulto , Feminino , Humanos , Masculino
4.
J Headache Pain ; 12(6): 653-6, 2011 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-21814746

RESUMO

Here we present the case of a 50-year-old man suffering from "painful tic convulsif", on the left side of the face, i.e., left trigeminal neuralgia associated with ipsilateral hemifacial spasm. An angio-MRI scan showed a neurovascular confliction of left superior cerebellar artery with the ipsilateral V cranial nerve and of the left inferior cerebellar artery with the ipsilateral VII cranial nerve. Neurophysiological evaluation through esteroceptive blink reflex showed the involvement of left facial nerve. An initial carbamazepine treatment (800 mg/daily) was completely ineffective, so the patient was shifted to lamotrigine 50 b.i.d. that was able to reduce attacks from 4 to 6 times per day to 1 to 2 per week. Considering the good response to the drug, the neurosurgeon decided to delay surgical treatment.


Assuntos
Artéria Basilar/patologia , Doenças do Nervo Facial/diagnóstico , Espasmo Hemifacial/diagnóstico , Neuralgia do Trigêmeo/diagnóstico , Insuficiência Vertebrobasilar/diagnóstico , Artéria Basilar/fisiopatologia , Doenças do Nervo Facial/complicações , Doenças do Nervo Facial/fisiopatologia , Espasmo Hemifacial/complicações , Espasmo Hemifacial/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento , Neuralgia do Trigêmeo/complicações , Neuralgia do Trigêmeo/fisiopatologia , Insuficiência Vertebrobasilar/complicações , Insuficiência Vertebrobasilar/fisiopatologia
5.
Percept Mot Skills ; 112(3): 915-25, 2011 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21853778

RESUMO

In the present study, differences in visuospatial attention lateralization were evaluated in athletes engaged in open-compared to closed-skill sports and sedentary nonathletes. 23 volleyball players (open skill; Italian national level and regional level), 10 rowers (closed skill, Italian national level), and 23 sedentary participants responded to a computerized line-length judgment task. Five lines, differing in the length of their right and left segments, were randomly presented; the respondent made a forced-choice decision about the respective length of the two segments. Volleyball players responded significantly faster; those at the higher competitive level were also more accurate, making a statistically significantly lower number of leftward errors as compared with rowers and controls. If such responses are due to training rather than self-selection of ability, then the results may suggest the possibility of changing the distribution of visuospatial attention by training in open-skill sports.


Assuntos
Desempenho Atlético , Atenção , Lateralidade Funcional , Orientação , Reconhecimento Visual de Modelos , Percepção de Tamanho , Percepção Espacial , Esportes/psicologia , Voleibol/psicologia , Adulto , Comportamento de Escolha , Humanos , Julgamento , Masculino , Tempo de Reação , Adulto Jovem
6.
Cephalalgia ; 30(1): 46-52, 2010 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-19438928

RESUMO

We showed reduced motor intracortical inhibition (ICI) and paradoxical increase of intracortical facilitation (ICF) to 1 Hz repetitive transcranial magnetic stimulation (rTMS) in patients affected by migraine with aura (MA). In conditions of enhanced excitability due to a reduced inhibition, high-frequency rTMS was found to potentiate intracortical inhibition. Here we explored the conditioning effects of high-frequency priming stimulation of motor cortex with the aim of normalizing excitability reverting paradoxical facilitation by 1 Hz rTMS in MA. Nine patients with MA and nine healthy controls underwent a paired-pulse TMS paradigm to evaluate motor intracortical excitability (ICI and ICF) before and after the following rTMS conditions: 1 Hz alone or preceded by a real or sham conditioning high-frequency (10 Hz) rTMS. Sham was used to control for rTMS specificity. In baseline, ICI was significantly lower in migraineurs with respect to controls. One hertz stimulation reduced motor evoked potential amplitude and ICF in healthy controls, while it caused a significant paradoxical ICF increase in migraineurs. High-frequency rTMS conditioning normalized excitability in migraine, increasing short ICI and so reversing the paradoxical effects of 1 Hz rTMS. These findings raise the possibility that the interictal reduced intracortical inhibition in migraine could be normalized by high-frequency rTMS. This would open perspectives for new treatment strategies in migraine prevention.


Assuntos
Enxaqueca com Aura/fisiopatologia , Enxaqueca com Aura/terapia , Córtex Motor/fisiologia , Estimulação Magnética Transcraniana/métodos , Adulto , Potencial Evocado Motor/fisiologia , Feminino , Humanos , Interneurônios/fisiologia , Masculino , Inibição Neural/fisiologia , Tratos Piramidais/fisiologia , Adulto Jovem
7.
Neurocase ; 16(3): 267-72, 2010 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-20104391

RESUMO

Previous studies of auditory hallucinations in schizophrenia found that the hallucinations were reduced by the application of transcranial magnetic stimulation (rTMS). Here we describe a case of traumatic brain injury associated with continuous music hallucinations. An MRI scan showed a structural lesion of the right temporal pole and a PET scan indicated a hyperactive area of the posterior right temporal lobe. We hypothesized that rTMS applied to the right temporal area would reduce this activity and the corresponding hallucinations. The patient's music hallucinations were significantly reduced by rTMS treatment. A PET scan following treatment also indicated that rTMS treatment reduced brain activity in the right temporal lobe. This case provides initial evidence that rTMS may be a successful treatment of syndromes associated with hyperactive brain areas.


Assuntos
Lesões Encefálicas/fisiopatologia , Alucinações/fisiopatologia , Alucinações/terapia , Música , Estimulação Magnética Transcraniana , Lesões Encefálicas/patologia , Alucinações/patologia , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Tomografia por Emissão de Pósitrons , Lobo Temporal/patologia , Lobo Temporal/fisiopatologia
9.
Exp Brain Res ; 192(4): 651-6, 2009 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-18815775

RESUMO

Recent evidence suggests a role for cerebellum in pathophysiology of dystonia. Here we explored, the cerebellar modulation of motor cortex in patients with focal upper limb dystonia. Eight patients and eight controls underwent a transcranial magnetic stimulation protocol to study the cerebellar-brain-inhibition (CBI): a conditioning cerebellar stimulus (CCS) was followed 5 ms after by the contralateral motor cortex stimulation (test stimulus: TS). We explored the effects of CBI on MEP amplitude, short intracortical inhibition (SICI) and intracortical facilitation (ICF) measures. At baseline no differences in TS-MEP amplitude, SICI or ICF were found between patients and controls. Cerebellar-conditioning significantly reduced TS-MEP amplitude, increased ICF, and decreased SICI in control subjects. In contrast, no changes in these neurophysiological measures were observed in the motor cortex of patients, regardless of which side was tested. If further confirmed, these findings suggest a reduced cerebellar modulation of motor cortex excitability in patients with focal dystonia.


Assuntos
Cerebelo/fisiopatologia , Distonia/fisiopatologia , Atividade Motora , Córtex Motor/fisiopatologia , Estimulação Magnética Transcraniana , Adulto , Análise de Variância , Braço/fisiopatologia , Feminino , Humanos , Masculino , Inibição Neural
11.
Brain Lang ; 104(2): 113-21, 2008 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-17964642

RESUMO

It has been claimed that verb processing (as opposed to noun processing) is subserved by specific neural circuits in the left prefrontal cortex. In this study, we took advantage of the unusual grammatical characteristics of clitic pronouns in Italian (e.g., lo and la in portalo and portala 'bring it [masculine]/[feminine]', respectively)-the fact that clitics have both nominal and verbal characteristics, to explore the neural correlates of verb and clitic processing. We used repetitive transcranial magnetic stimulation (rTMS) to suppress the excitability of the left prefrontal cortex and to assess its role in producing verb+det+noun and verb+clitic phrases. Results showed an interference effect for both kinds of phrases when stimulation was applied to the left but not to the right prefrontal cortex. However, the interference effect was significantly greater for the verb+clitic than for the verb+det+noun phrases. These findings support the view that clitics increase the morphosyntactic complexity of verbs.


Assuntos
Lateralidade Funcional , Idioma , Córtex Pré-Frontal/fisiologia , Adulto , Estimulação Elétrica , Humanos , Itália , Magnetismo , Psicolinguística , Tempo de Reação
12.
J Neurol Sci ; 263(1-2): 107-12, 2007 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-17655867

RESUMO

The aim of this study was to investigate the role of the cerebellum in a temporal-discrimination task without movement production in healthy subjects. Ten healthy subjects underwent a time-perception task with somatosensory stimuli. Two pairs of electrical stimuli: the first considered the reference pair (rp) with a standard interval of 400 ms and the second, the test pair (tp), with variable intervals ranging from 300 to 500 ms, were applied by surface electrodes on the right forearm. Subjects were instructed to compare time intervals of rp and tp and to estimate whether the tp interval was shorter than, equal to, or longer than that of rp. The task was performed in baseline and after 1 Hz rTMS over the right and left cerebellar hemisphere. The right cerebellar rTMS worsened temporal discrimination of cutaneous somatosensory electrical stimuli on the ipsilateral hand. rTMS of the left cerebellar hemisphere did not determine significant changes in the subjects' performance with respect to the baseline. These findings suggest that the cerebellum plays a role in merely perceptive aspects of temporal information processing.


Assuntos
Cerebelo/fisiologia , Percepção do Tempo/fisiologia , Estimulação Magnética Transcraniana , Adolescente , Adulto , Análise de Variância , Discriminação Psicológica/fisiologia , Estimulação Elétrica/métodos , Feminino , Lateralidade Funcional , Humanos , Masculino , Testes Neuropsicológicos , Fatores de Tempo
13.
Clin Neurophysiol ; 128(5): 792-798, 2017 05.
Artigo em Inglês | MEDLINE | ID: mdl-28319880

RESUMO

OBJECTIVE: To investigate electrophysiologically the reproducibility of oropharyngeal swallowing in patients with ALS. METHODS: We enrolled 26 ALS patients, both with and without clinical signs of dysphagia, and 30 age-matched controls. The reproducibility of the electrophysiological signals related to the oral phase (electromyographic activity of the submental/suprahyoid muscles) and the pharyngeal phase (laryngeal-pharyngeal mechanogram) of swallowing across repeated swallows was assessed. To do this we computed two similarity indexes (SI) by using previously described mathematical algorithms. RESULTS: The reproducibility of oropharyngeal swallowing was significantly reduced both in patients with and in those without clinical signs of dysphagia, with more marked alterations being detected in the dysphagic group. The SI of both phases of swallowing, oral and pharyngeal, correlated significantly with dysphagia severity and disease severity. CONCLUSIONS: In ALS different pathophysiological mechanisms can alter the stereotyped motor behaviors underlying normal swallowing, thus reducing the reproducibility of the swallowing act. A decrease in swallowing reproducibility could be a preclinical sign of dysphagia and, beyond a certain threshold, a pathological hallmark of oropharyngeal dysphagia. SIGNIFICANCE: Electrophysiological assessment is a simple and useful tool for the early detection of swallowing abnormalities, and for the management of overt dysphagia in ALS.


Assuntos
Esclerose Lateral Amiotrófica/diagnóstico , Transtornos de Deglutição/diagnóstico , Deglutição , Eletromiografia/métodos , Adulto , Idoso , Esclerose Lateral Amiotrófica/complicações , Esclerose Lateral Amiotrófica/fisiopatologia , Estudos de Casos e Controles , Transtornos de Deglutição/etiologia , Transtornos de Deglutição/fisiopatologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Faringe/fisiopatologia , Reprodutibilidade dos Testes
14.
J Neurol Sci ; 235(1-2): 19-22, 2005 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-15961108

RESUMO

The aim of the study was to explore excitability of a motor and a non-motor (visual) area in patients affected by Friedreich ataxia and to correlate neurophysiological data with clinical parameters. Seven patients (3M/4F) and ten healthy controls (5M/5F) participated in the study. The hot-spot for activation of right abductor pollicis brevis was checked by means of a figure-of-eight coil and the motor threshold (MT) on this point was recorded. The phosphene threshold (PT) was measured by means of a focal coil over the occipital cortex as the lower intensity of magnetic stimulation able to induce the perception of phosphenes. The patients showed a significantly higher mean PT (p<.03) and MT values (p<.001) than controls. In all but one patient unable to perceive phosphenes (42% vs. 50% of controls), TMS at 100% intensity did not elicit motor response at rest. The difference in percentage of patients (57.1%) and controls (100%) with motor responses was nearly significant. The size of GAA1 expansion showed significant correlations with PT and MT values. The results of our study showed that FA patients had reduced cortical activation, involving both the motor and the visual cortex. The cortical involvement in these patients seems to be mainly genetically determined. The study provides the first evidence of cortical dysfunction in patients with genetically defined Friedreich ataxia.


Assuntos
Estimulação Elétrica/métodos , Ataxia de Friedreich/fisiopatologia , Magnetismo , Córtex Motor/efeitos da radiação , Fosfenos/efeitos da radiação , Córtex Visual/efeitos da radiação , Adolescente , Adulto , Mapeamento Encefálico , Feminino , Ataxia de Friedreich/genética , Humanos , Masculino , Córtex Motor/fisiopatologia , Fosfenos/fisiologia , Limiar Sensorial , Expansão das Repetições de Trinucleotídeos/fisiologia , Córtex Visual/fisiopatologia
15.
Neurology ; 57(7): 1338-40, 2001 Oct 09.
Artigo em Inglês | MEDLINE | ID: mdl-11591865

RESUMO

To verify the role of interhemispheric influences on manifestations of neglect, the authors investigated the effects of a transient repetitive transcranial magnetic stimulation (rTMS)-induced disruption of the unaffected hemisphere on contralesional visuospatial neglect in two left- and five right-brain-damaged patients. Parietal rTMS of the unaffected hemisphere during the execution of a computerized task of bisected line's length judgment transiently decreased the magnitude of neglect as expressed in the number of errors.


Assuntos
Lateralidade Funcional , Magnetismo , Transtornos da Percepção/fisiopatologia , Idoso , Atenção , Estimulação Elétrica , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Lobo Parietal/fisiopatologia , Estimulação Luminosa
16.
Neuroreport ; 12(11): 2605-7, 2001 Aug 08.
Artigo em Inglês | MEDLINE | ID: mdl-11496157

RESUMO

In a recent study we showed that repetitive transcranial magnetic stimulation (rTMS) with train duration of 400 ms over right frontal and right posterior parietal cortices gives rise to transitory contralateral visuo-spatial neglect in normal subjects. In the present experiment we investigated whether using single-pulse TMS it is possible to obtain information about the timing of cortical activity related to spatial cognition. Nine healthy subjects performed in baseline condition and during TMS a tachistoscopic task, requiring a forced-choice estimation of the length of the two segments of prebisected horizontal lines. Single-pulse TMS was triggered at various time intervals (150 ms, 225 ms, 300 ms) after visual stimulus onset with a focal coil over P6 and F4 (according to 10/20 EEG system). Relative transitory rightward bias was observed only when parietal TMS was delivered 150 ms after visual stimulus presentation. Frontal stimulation induced no effect on visuo-spatial perception with the time intervals explored.


Assuntos
Lobo Frontal/fisiologia , Magnetismo , Lobo Parietal/fisiologia , Percepção Espacial/fisiologia , Adulto , Idoso , Análise de Variância , Estimulação Elétrica , Humanos , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Transtornos da Percepção/fisiopatologia , Estimulação Luminosa , Tempo de Reação/fisiologia
17.
Neuroreport ; 11(7): 1519-21, 2000 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-10841369

RESUMO

We applied repetitive transcranial magnetic stimulation (rTMS) in order to induce interference on visuo-spatial perception in 11 healthy subjects. Subjects performed a visuo-spatial task requiring judgements about the symmetry of prebisected lines. Visual stimuli consisted of symmetrically or asymmetrically transected lines, tachystoscopically presented for 50 ms on a computer-monitor. Performance was examined in basal condition and during rTMS trains of 10 stimuli at 25 Hz, delivered through a focal coil over right or left posterior parietal cortex (P5 and P6 sites) and triggered synchronously with visual stimulus. Randomly intermixed sham rTMS trains were employed to control for non-specific effects. Right parietal rTMS induced a significant rightward bias in symmetry judgements as compared with basal and sham rTMS conditions. No differences emerged between other conditions.


Assuntos
Agnosia/fisiopatologia , Lateralidade Funcional/fisiologia , Magnetismo , Lobo Parietal/fisiologia , Percepção Espacial/fisiologia , Adulto , Idoso , Estimulação Elétrica , Humanos , Pessoa de Meia-Idade , Estimulação Luminosa , Desempenho Psicomotor/fisiologia
18.
Clin Neurophysiol ; 110(5): 806-12, 1999 May.
Artigo em Inglês | MEDLINE | ID: mdl-10400193

RESUMO

OBJECTIVE: Focal transcranial magnetic stimulation (TMS) was used to study the motor maps of upper limb muscles in 7 adult patients with a history of paralytic poliomyelitis. The aim of the study was to verify the potential for long-term cortical reorganization of a selective peripheral motor neuron lesion suffered early in life. METHODS: Patient selection was based on the prevalent involvement of proximal muscles in only one of the upper limbs. Motor evoked potentials (MEPs) were recorded from deltoid and abductor pollicis brevis (APB) muscles. Each muscle map was characterized by area (no. of excitable positions), volume (the sum of MEP amplitudes at all scalp positions), maximal amplitude (the highest MEP recorded). RESULTS: In the patients, the mean area, volume and maximal amplitude were significantly greater in affected vs. contralateral deltoid (P<0.05) and vs. controls (P<0.01). No significant differences were found in APB map parameters. The APB/deltoid ratio for area was lower in the affected compared with the unaffected side and controls (P = 0.06). Cortical reorganization was not significantly correlated with motor performance. CONCLUSION: These findings are consistent with a rearrangement in human motor pathways targeting muscles affected by a lower motor neuron lesion.


Assuntos
Córtex Motor/fisiopatologia , Poliomielite/fisiopatologia , Adulto , Mapeamento Encefálico , Eletroencefalografia , Feminino , Humanos , Magnetismo , Masculino , Pessoa de Meia-Idade
19.
Neurosci Lett ; 336(2): 131-3, 2003 Jan 16.
Artigo em Inglês | MEDLINE | ID: mdl-12499057

RESUMO

The aim of the study was to investigate whether low-frequency repetitive transcranial magnetic stimulation (rTMS) over the unaffected hemisphere can ameliorate visuospatial neglect. We treated three right brain damaged patients with left neglect. 900 pulses (1 Hz frequency) were given over left posterior parietal cortex every other day for 2 weeks. Patients performed a computerized task requiring length judgement of prebisected lines, tachistoscopically presented for 150 ms. With respect to rTMS the task was given 15 days before, at the beginning, at the end and 15 days after. At these times patients performed also line bisection and clock drawing tasks. rTMS induced a significant improvement of visuo-spatial performance that remained quite unchanged 15 days after. Patients performance at Time 3 and 4 improved also as concerns line bisection and clock drawing tasks.


Assuntos
Agnosia/reabilitação , Campos Eletromagnéticos , Lobo Parietal/efeitos da radiação , Desempenho Psicomotor/efeitos da radiação , Percepção Espacial , Percepção Visual , Idoso , Agnosia/etiologia , Isquemia Encefálica/complicações , Potencial Evocado Motor/efeitos da radiação , Humanos , Masculino , Pessoa de Meia-Idade , Lobo Parietal/fisiopatologia , Transtornos da Percepção/etiologia , Transtornos da Percepção/reabilitação , Resultado do Tratamento
20.
J Neurol Sci ; 174(2): 122-6, 2000 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-10727697

RESUMO

The aim of the study was to assess if the observation of single or more complex muscle movements activates the premotor cortex in man. We stimulated by transcranial magnetic stimulation the right and left motor cortex recording from the abductor pollicis brevis of eight normal subjects, during observation of different movements performed by the examiner: (1) single movements: thumb abduction, arm elevation; (2) motor sequences: finger opposing movements performed in an ordinate sequence: 1-2, 1-3, 1-4, 1-5, 1-2ellipsis, and in a non-consecutive non-repetitive order: 1-3, 1-5, 1-4, 1-2, 1-5, 1-2ellipsis We found an increased excitability of the right cortex during observation of isolated muscle movement regardless of which muscle is moved. At the stimulation of the left cortex, MEPs were significantly increased during observation of complex muscular synergies.


Assuntos
Campos Eletromagnéticos , Atividade Motora/fisiologia , Córtex Motor/fisiologia , Adulto , Braço/fisiologia , Dominância Cerebral , Estimulação Elétrica , Potenciais Evocados , Feminino , Dedos/fisiologia , Humanos , Masculino , Rede Nervosa/fisiologia , Polegar/fisiologia
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