Pesquisa | BVS Violência e Saúde

1.

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry.

Zhang, Fan; Wei, Kevin; Slowikowski, Kamil; Fonseka, Chamith Y; Rao, Deepak A; Kelly, Stephen; Goodman, Susan M; Tabechian, Darren; Hughes, Laura B; Salomon-Escoto, Karen; Watts, Gerald F M; Jonsson, A Helena; Rangel-Moreno, Javier; Meednu, Nida; Rozo, Cristina; Apruzzese, William; Eisenhaure, Thomas M; Lieb, David J; Boyle, David L; Mandelin, Arthur M; Boyce, Brendan F; DiCarlo, Edward; Gravallese, Ellen M; Gregersen, Peter K; Moreland, Larry; Firestein, Gary S; Hacohen, Nir; Nusbaum, Chad; Lederer, James A; Perlman, Harris; Pitzalis, Costantino; Filer, Andrew; Holers, V Michael; Bykerk, Vivian P; Donlin, Laura T; Anolik, Jennifer H; Brenner, Michael B; Raychaudhuri, Soumya.

Nat Immunol ; 20(7): 928-942, 2019 07.

Artigo em Inglês | MEDLINE | ID: mdl-31061532

2.

The pathogenesis of rheumatoid arthritis.

Alivernini, Stefano; Firestein, Gary S; McInnes, Iain B.

Immunity ; 55(12): 2255-2270, 2022 12 13.

Artigo em Inglês | MEDLINE | ID: mdl-36516818

3.

Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes.

Zhang, Fan; Jonsson, Anna Helena; Nathan, Aparna; Millard, Nghia; Curtis, Michelle; Xiao, Qian; Gutierrez-Arcelus, Maria; Apruzzese, William; Watts, Gerald F M; Weisenfeld, Dana; Nayar, Saba; Rangel-Moreno, Javier; Meednu, Nida; Marks, Kathryne E; Mantel, Ian; Kang, Joyce B; Rumker, Laurie; Mears, Joseph; Slowikowski, Kamil; Weinand, Kathryn; Orange, Dana E; Geraldino-Pardilla, Laura; Deane, Kevin D; Tabechian, Darren; Ceponis, Arnoldas; Firestein, Gary S; Maybury, Mark; Sahbudin, Ilfita; Ben-Artzi, Ami; Mandelin, Arthur M; Nerviani, Alessandra; Lewis, Myles J; Rivellese, Felice; Pitzalis, Costantino; Hughes, Laura B; Horowitz, Diane; DiCarlo, Edward; Gravallese, Ellen M; Boyce, Brendan F; Moreland, Larry W; Goodman, Susan M; Perlman, Harris; Holers, V Michael; Liao, Katherine P; Filer, Andrew; Bykerk, Vivian P; Wei, Kevin; Rao, Deepak A; Donlin, Laura T; Anolik, Jennifer H.

Nature ; 623(7987): 616-624, 2023 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-37938773

4.

Immunopathogenesis of Rheumatoid Arthritis.

Firestein, Gary S; McInnes, Iain B.

Immunity ; 46(2): 183-196, 2017 02 21.

Artigo em Inglês | MEDLINE | ID: mdl-28228278

5.

IgG Epitopes Processed and Presented by IgG⁺ B Cells Induce Suppression by Human Thymic-Derived Regulatory T Cells.

Hsieh, Li-En; Sidney, John; Burns, Jane C; Boyle, David L; Firestein, Gary S; Altman, Yoav; Sette, Alessandro; Franco, Alessandra.

J Immunol ; 206(6): 1194-1203, 2021 03 15.

Artigo em Inglês | MEDLINE | ID: mdl-33579724

6.

What Is Rheumatoid Arthritis?

Gravallese, Ellen M; Firestein, Gary S; Koscal, Natalie; Ling, Emily; Longo, Dan L; Messenger, Lori A; Schubach, Abigail.

N Engl J Med ; 390(13): e32, 2024 Apr 04.

Artigo em Inglês | MEDLINE | ID: mdl-38598569

7.

Rheumatoid Arthritis - Common Origins, Divergent Mechanisms.

Gravallese, Ellen M; Firestein, Gary S.

N Engl J Med ; 388(6): 529-542, 2023 02 09.

Artigo em Inglês | MEDLINE | ID: mdl-36780677

8.

Rheumatoid Arthritis. Reply.

Gravallese, Ellen M; Firestein, Gary S.

N Engl J Med ; 388(20): 1919-1920, 2023 May 18.

Artigo em Inglês | MEDLINE | ID: mdl-37195963

9.

Persistent Joint Pain Following Arthropod Virus Infections.

Suchowiecki, Karol; Reid, St Patrick; Simon, Gary L; Firestein, Gary S; Chang, Aileen.

Curr Rheumatol Rep ; 23(4): 26, 2021 04 13.

Artigo em Inglês | MEDLINE | ID: mdl-33847834

10.

PTPN14 phosphatase and YAP promote TGFß signalling in rheumatoid synoviocytes.

Bottini, Angel; Wu, Dennis J; Ai, Rizi; Le Roux, Michelle; Bartok, Beatrix; Bombardieri, Michele; Doody, Karen M; Zhang, Vida; Sacchetti, Cristiano; Zoccheddu, Martina; Lonic, Ana; Li, Xiaochun; Boyle, David L; Hammaker, Deepa; Meng, Tzu-Ching; Liu, Lin; Corr, Maripat; Stanford, Stephanie M; Lewis, Myles; Wang, Wei; Firestein, Gary S; Khew-Goodall, Yeesim; Pitzalis, Costantino; Bottini, Nunzio.

Ann Rheum Dis ; 78(5): 600-609, 2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-30808624

11.

Toreforant, an orally active histamine H₄-receptor antagonist, in patients with active rheumatoid arthritis despite methotrexate: mechanism of action results from a phase 2, multicenter, randomized, double-blind, placebo-controlled synovial biopsy study.

Boyle, David L; DePrimo, Samuel E; Calderon, Cesar; Chen, Dion; Dunford, Paul J; Barchuk, William; Firestein, Gary S; Thurmond, Robin L.

Inflamm Res ; 68(4): 261-274, 2019 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-30739130

12.

Regulation of the Cell Cycle and Inflammatory Arthritis by the Transcription Cofactor LBH Gene.

Matsuda, Shinji; Hammaker, Deepa; Topolewski, Katharyn; Briegel, Karoline J; Boyle, David L; Dowdy, Steven; Wang, Wei; Firestein, Gary S.

J Immunol ; 199(7): 2316-2322, 2017 10 01.

Artigo em Inglês | MEDLINE | ID: mdl-28807995

13.

Epigenetics of inflammatory arthritis.

Hammaker, Deepa; Firestein, Gary S.

Curr Opin Rheumatol ; 30(2): 188-196, 2018 03.

Artigo em Inglês | MEDLINE | ID: mdl-29194108

14.

Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis.

Bustamante, Marta F; Oliveira, Patricia G; Garcia-Carbonell, Ricard; Croft, Adam P; Smith, Jeff M; Serrano, Ramon L; Sanchez-Lopez, Elsa; Liu, Xiao; Kisseleva, Tatiana; Hay, Nissim; Buckley, Christopher D; Firestein, Gary S; Murphy, Anne N; Miyamoto, Shigeki; Guma, Monica.

Ann Rheum Dis ; 77(11): 1636-1643, 2018 11.

Artigo em Inglês | MEDLINE | ID: mdl-30061164

15.

Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.

Brydges, Susannah D; Mueller, James L; McGeough, Matthew D; Pena, Carla A; Misaghi, Amirhossein; Gandhi, Chhavi; Putnam, Chris D; Boyle, David L; Firestein, Gary S; Horner, Anthony A; Soroosh, Pejman; Watford, Wendy T; O'Shea, John J; Kastner, Daniel L; Hoffman, Hal M.

Immunity ; 30(6): 875-87, 2009 Jun 19.

Artigo em Inglês | MEDLINE | ID: mdl-19501000

16.

PATHOGENESIS OF RHEUMATOID ARTHRITIS: THE INTERSECTION OF GENETICS AND EPIGENETICS.

Firestein, Gary S.

Trans Am Clin Climatol Assoc ; 129: 171-182, 2018.

Artigo em Inglês | MEDLINE | ID: mdl-30166712

17.

Computationally expanding infinium HumanMethylation450 BeadChip array data to reveal distinct DNA methylation patterns of rheumatoid arthritis.

Fan, Shicai; Li, Chengzhe; Ai, Rizi; Wang, Mengchi; Firestein, Gary S; Wang, Wei.

Bioinformatics ; 32(12): 1773-8, 2016 06 15.

Artigo em Inglês | MEDLINE | ID: mdl-26883487

18.

TGFß responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness.

Stanford, Stephanie M; Aleman Muench, German R; Bartok, Beatrix; Sacchetti, Cristiano; Kiosses, William B; Sharma, Jay; Maestre, Michael F; Bottini, Massimo; Mustelin, Tomas; Boyle, David L; Firestein, Gary S; Bottini, Nunzio.

Ann Rheum Dis ; 75(1): 295-302, 2016 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-25378349

19.

Phosphoinositide 3-kinase Î´ regulates migration and invasion of synoviocytes in rheumatoid arthritis.

Bartok, Beatrix; Hammaker, Deepa; Firestein, Gary S.

J Immunol ; 192(5): 2063-70, 2014 Mar 01.

Artigo em Inglês | MEDLINE | ID: mdl-24470496

20.

Anti-Inflammatory Effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1S, a Selective c-Jun N-Terminal Kinase Inhibitor.

Schepetkin, Igor A; Kirpotina, Liliya N; Hammaker, Deepa; Kochetkova, Irina; Khlebnikov, Andrei I; Lyakhov, Sergey A; Firestein, Gary S; Quinn, Mark T.

J Pharmacol Exp Ther ; 353(3): 505-16, 2015 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-25784649

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