Detalhe da pesquisa
1.
Visible-Light-Initiated Manganese Catalysis for C-H Alkylation of Heteroarenes: Applications and Mechanistic Studies.
Angew Chem Int Ed Engl
; 56(48): 15309-15313, 2017 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28960645
2.
Modern advances in heterocyclic chemistry in drug discovery.
Org Biomol Chem
; 14(28): 6611-37, 2016 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27282396
3.
Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation.
Bioorg Med Chem Lett
; 23(4): 1114-9, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23260349
4.
Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: use of a conformation-based hypothesis to facilitate compound design.
Bioorg Med Chem Lett
; 23(4): 1120-6, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23298810
5.
MMP-13 selective alpha-sulfone hydroxamates: identification of selective P1' amides.
Bioorg Med Chem Lett
; 21(10): 2823-5, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21493063
6.
Acidic triazoles as soluble guanylate cyclase stimulators.
Bioorg Med Chem Lett
; 21(21): 6515-8, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21924901
7.
Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one.
Bioorg Med Chem Lett
; 19(17): 5209-13, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19631533
8.
Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system.
Bioorg Med Chem Lett
; 19(15): 4092-6, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19539468
9.
Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors.
Bioorg Med Chem Lett
; 19(15): 4088-91, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19540112
10.
Physiochemical drug properties associated with in vivo toxicological outcomes.
Bioorg Med Chem Lett
; 18(17): 4872-5, 2008 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18691886
11.
Discovery of a simple picomolar inhibitor of cholesteryl ester transfer protein.
J Med Chem
; 46(11): 2152-68, 2003 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-12747787
12.
Chiral N,N-disubstituted trifluoro-3-amino-2-propanols are potent inhibitors of cholesteryl ester transfer protein.
J Med Chem
; 45(18): 3891-904, 2002 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-12190312
13.
Driving external chemistry optimization via operations management principles.
Drug Discov Today
; 19(3): 289-94, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23973340
14.
Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5).
J Med Chem
; 53(6): 2656-60, 2010 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-20196613
15.
Design of potent inhibitors of human beta-secretase. Part 2.
Bioorg Med Chem Lett
; 17(1): 78-81, 2007 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17049233
16.
Design of potent inhibitors of human beta-secretase. Part 1.
Bioorg Med Chem Lett
; 17(1): 73-7, 2007 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17046251