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1.
Nano Lett ; 23(16): 7311-7318, 2023 Aug 23.
Artigo em Inglês | MEDLINE | ID: mdl-37561818

RESUMO

Superconductor-semiconductor nanowire hybrid structures are useful in fabricating devices for quantum information processing. While selective area growth (SAG) offers the flexibility to grow semiconductor nanowires in arbitrary geometries, in situ evaporation of superconductors ensures pristine superconductor-semiconductor interfaces, resulting in strong induced superconductivity in the semiconducting nanowire. In this work, we used high-aspect-ratio SiOx dielectric walls to in situ evaporate islands of superconductor tin on in-plane InAs SAG nanowires. Our technique enables customization in the designs of such hybrid nanostructures, while simultaneously performing the nanowire and superconductor growth without breaking vacuum. Using this technique, we grew super(S)-normal(N)-super(S), NS, and SNSNS junctions. We performed cryogenic electron transport measurements revealing the presence of gate and field tunable supercurrents. We further measured the superconducting gap and critical fields in the hybrid nanostructures and the crossover from 2e to 1e periodicity in the SNSNS junctions as a proof of the usability of these hybrid nanostructures.

2.
Nanotechnology ; 35(7)2023 Nov 28.
Artigo em Inglês | MEDLINE | ID: mdl-37890472

RESUMO

Metal deposition with cryogenic cooling is a common technique in the condensed matter community for producing ultra-thin epitaxial superconducting layers on semiconductors. However, a significant challenge arises when these films return to room temperature, as they tend to undergo dewetting. This issue can be mitigated by capping the films with an amorphous layer. In this study, we investigate the influence of differentin situfabricated caps on the structural characteristics of Sn thin films deposited at 80 K on InSb substrates. Regardless of the type of capping, we consistently observe that the films remain smooth upon returning to room temperature and exhibit epitaxy on InSb in the cubic Sn (α-Sn) phase. Notably, we identify a correlation between alumina capping using an electron beam evaporator and an increased presence of tetragonal Sn (ß-Sn) grains. This suggests that heating from the alumina source may induce a partial phase transition in the Sn layer. The existence of theß-Sn phase induces superconducting behavior of the films by percolation effect. This study highlights the potential for tailoring the structural properties of cryogenic Sn thin films throughin situcapping. This development opens avenues for precise control in the production of superconducting Sn films, facilitating their integration into quantum computing platforms.

3.
Phys Rev Lett ; 128(4): 046801, 2022 Jan 28.
Artigo em Inglês | MEDLINE | ID: mdl-35148137

RESUMO

We investigate an electron transport blockade regime in which a spin triplet localized in the path of current is forbidden from entering a spin-singlet superconductor. To stabilize the triplet, a double quantum dot is created electrostatically near a superconducting Al lead in an InAs nanowire. The quantum dot closest to the normal lead exhibits Coulomb diamonds, and the dot closest to the superconducting lead exhibits Andreev bound states and an induced gap. The experimental observations compare favorably to a theoretical model of Andreev blockade, named so because the triplet double dot configuration suppresses Andreev reflections. Observed leakage currents can be accounted for by finite temperature. We observe the predicted quadruple level degeneracy points of high current and a periodic conductance pattern controlled by the occupation of the normal dot. Even-odd transport asymmetry is lifted with increased temperature and magnetic field. This blockade phenomenon can be used to study spin structure of superconductors. It may also find utility in quantum computing devices that use Andreev or Majorana states.

5.
Nano Lett ; 19(2): 1023-1027, 2019 02 13.
Artigo em Inglês | MEDLINE | ID: mdl-30633528

RESUMO

Hybrid superconductor-semiconductor structures attract increasing attention owing to a variety of potential applications in quantum computing devices. They can serve the realization of topological superconducting systems as well as gate-tunable superconducting quantum bits. Here, we combine a SiGe/Ge/SiGe quantum-well heterostructure hosting high-mobility two-dimensional holes and aluminum superconducting leads to realize prototypical hybrid devices, such as Josephson field-effect transistors (JoFETs) and superconducting quantum interference devices (SQUIDs). We observe gate-controlled supercurrent transport with Ge channels as long as one micrometer and estimate the induced superconducting gap from tunnel spectroscopy measurements. Transmission electron microscopy reveals the diffusion of Ge into the Al contacts, whereas no Al is detected in the Ge channel.

6.
Biomed Eng Online ; 18(1): 82, 2019 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-31340820

RESUMO

BACKGROUND: The use of flow-diverters for non-saccular cerebral posterior circulation aneurysms requires complex deployment techniques and is associated with high mortality and morbidity. Therefore, further studies are required to clarify the effect of stenting on post-treatment hemodynamics in such aneurysms. In this study, we evaluated flow alterations in a treated giant fusiform aneurysm of the vertebrobasilar junction and correlated them with the clinical outcome. METHODS: A patient-specific aneurysm model was acquired by rotational angiography, and three SILK flow-diverters (4.5 × 40, 5 × 40 and 5.5 × 40 mm) were virtually deployed in series along the basilar and right vertebral arteries. Image-based blood flow simulations before and after the treatment were performed under realistic pulsatile flow conditions. The flow reduction, velocity and wall shear stress (WSS) distribution, streamlines and WSS-derived parameters were evaluated before and after the treatment. RESULTS: The computed velocity streamlines showed substantial alterations of the flow pattern in the aneurysm and successful redirection of blood flow along the series of flow-diverters with no flow through the overlapping stents. The obtained flow reduction of 86% was sufficient to create thrombogenic flow conditions. Moreover, a 6.2-fold increase in relative residence time and a decrease by 87% of time-averaged WSS contributed to a successful treatment outcome observed during the follow-up. CONCLUSIONS: We found a correlation between the numerically predicted flow alterations and the available treatment outcome. This shows the potential of image-based simulations to be used in clinical practice for treatment planning and estimation of possible risk factors associated with a complex stent deployment in fusiform aneurysms of the posterior circulation.


Assuntos
Hemodinâmica , Aneurisma Intracraniano/fisiopatologia , Aneurisma Intracraniano/terapia , Stents , Artéria Vertebral/fisiopatologia , Angiografia , Simulação por Computador , Humanos , Imageamento Tridimensional , Aneurisma Intracraniano/diagnóstico por imagem , Resultado do Tratamento , Artéria Vertebral/diagnóstico por imagem
7.
Phys Rev Lett ; 119(18): 187704, 2017 Nov 03.
Artigo em Inglês | MEDLINE | ID: mdl-29219554

RESUMO

Junctions created by coupling two superconductors via a semiconductor nanowire in the presence of high magnetic fields are the basis for the potential detection, fusion, and braiding of Majorana bound states. We study NbTiN/InSb nanowire/NbTiN Josephson junctions and find that the dependence of the critical current on the magnetic field exhibits gate-tunable nodes. This is in contrast with a well-known Fraunhofer effect, under which critical current nodes form a regular pattern with a period fixed by the junction area. Based on a realistic numerical model we conclude that the Zeeman effect induced by the magnetic field and the spin-orbit interaction in the nanowire are insufficient to explain the observed evolution of the Josephson effect. We find the interference between the few occupied one-dimensional modes in the nanowire to be the dominant mechanism responsible for the critical current behavior. We also report a strong suppression of critical currents at finite magnetic fields that should be taken into account when designing circuits based on Majorana bound states.

8.
Nano Lett ; 13(2): 387-91, 2013 Feb 13.
Artigo em Inglês | MEDLINE | ID: mdl-23259576

RESUMO

Ballistic one-dimensional transport in semiconductor nanowires plays a central role in creating topological and helical states. The hallmark of such one-dimensional transport is conductance quantization. Here we show conductance quantization in InSb nanowires at nonzero magnetic fields. Conductance plateaus are studied as a function of source-drain bias and magnetic field, enabling extraction of the Landé g factor and the subband spacing.

9.
Cryo Letters ; 35(2): 83-9, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24869649

RESUMO

BACKGROUND: Preserving the genetic diversity of Central Asia includes conserving wild apricots found in the foothills of several mountain ranges. These include primitive and genetically diverse populations with important characteristics for crop improvement. Apricot seeds have a short storage life, so cryopreservation of the seeds of wild populations is important for conserving the genetic diversity. OBJECTIVE: This study was to determine a suitable protocol for long-term storage. METHODS: This study tested a range of protocols using embryos and embryonic axes for storage of an important population of wild apricots and to determine if seed size and the distribution of moisture in the seed play a role in successful cryopreservation. RESULTS: Germination of scarified whole seed from trees in the Jungar population of Prunus armeniaca varied from 63 to 90 percent after 1 h in liquid nitrogen (LN) and was generally better at 7 % moisture content (MC) than at the original 14 percent MC. Embryos (4 percent MC) from stratified seed had only 33 % germination after LN exposure. Isolated embryonic axes from non-stratified seed germinated at 86 to 100 % following drying to 4 % or 7 % MC. Examination of three seed sizes determined that the MC of whole seed, embryos and isolated axes varied with the seed size and shape. MC of whole seeds and embryos decreased as size decreased, however, the axis MC did not. MC of medium-size seed was more evenly distributed between the axis and endosperm than in the larger or smaller samples. Cryopreservation of axes from medium-sized seed was good at any moisture content and a 1-h drying time was significantly better than 90 min. for axes of all seed sizes. Cryopreservation of axes using vitrification protocols initially designed for shoot tips produced germination similar to or lower than seed and axis drying techniques. CONCLUSION: We recommend storing apricot germplasm as unstratified seed dried to 7 % MC or as isolated embryonic axes.


Assuntos
Criopreservação , Prunus/fisiologia , Sementes/fisiologia , Vitrificação , Adaptação Fisiológica , Temperatura Baixa , Conservação dos Recursos Naturais , Dessecação , Germinação/fisiologia , Cazaquistão , Nitrogênio , Prunus/anatomia & histologia , Sementes/anatomia & histologia , Água/metabolismo
10.
J Plast Reconstr Aesthet Surg ; 88: 15-23, 2024 01.
Artigo em Inglês | MEDLINE | ID: mdl-37950987

RESUMO

BACKGROUND: The approach to constructing the cartilage framework for ear reconstruction is sufficiently established. However, there is still no consensus about the age of initiation of surgical treatment. This study aims to assess the development and growth of the costal cartilage to determine the best age to perform ear reconstruction surgery. METHODS: Out of 107 patients, we used presurgical treatment data for 40 patients and medical records for 67 patients aged 5-40. Computed tomography (CT) scans were performed, and average parameters were calculated (length, width, thickness, cartilage density, and standard deviation in Hounsfield units) of the cartilaginous part of the 6th, 7th, 8th, and 9th ribs. RESULTS: The required values were reached at 9-10 years old. CONCLUSION: The criteria for starting surgical treatment in the Russian population was determined by the width of the 6th-7th ribs synchondrosis, which must be equal to the width of a healthy auricle, and the length of the 8th rib should be longer than 9 cm. Therefore, the optimal age for ear reconstruction with autologous costal cartilage is 10 years and older. However, reconstruction can be made earlier in specific cases, according to height and weight and the preoperative CT scan.


Assuntos
Microtia Congênita , Cartilagem Costal , Pavilhão Auricular , Procedimentos de Cirurgia Plástica , Humanos , Criança , Orelha Externa/cirurgia , Costelas/diagnóstico por imagem , Costelas/cirurgia , Cartilagem/diagnóstico por imagem , Cartilagem/cirurgia , Cartilagem Costal/diagnóstico por imagem , Pavilhão Auricular/cirurgia , Tomografia Computadorizada por Raios X , Microtia Congênita/cirurgia , Cartilagem da Orelha/diagnóstico por imagem , Cartilagem da Orelha/cirurgia
11.
Nano Lett ; 12(4): 1794-8, 2012 Apr 11.
Artigo em Inglês | MEDLINE | ID: mdl-22364222

RESUMO

High aspect ratios are highly desired to fully exploit the one-dimensional properties of indium antimonide nanowires. Here we systematically investigate the growth mechanisms and find parameters leading to long and thin nanowires. Variation of the V/III ratio and the nanowire density are found to have the same influence on the "local" growth conditions and can control the InSb shape from thin nanowires to nanocubes. We propose that the V/III ratio controls the droplet composition and the radial growth rate and these parameters determine the nanowire shape. A sweet spot is found for nanowire interdistances around 500 nm leading to aspect ratios up to 35. High electron mobilities up to 3.5 × 10(4) cm(2) V(-1) s(-1) enable the realization of complex spintronic and topological devices.

12.
ACS Appl Mater Interfaces ; 15(12): 16288-16298, 2023 Mar 29.
Artigo em Inglês | MEDLINE | ID: mdl-36940162

RESUMO

Majorana zero modes, with prospective applications in topological quantum computing, are expected to arise in superconductor/semiconductor interfaces, such as ß-Sn and InSb. However, proximity to the superconductor may also adversely affect the semiconductor's local properties. A tunnel barrier inserted at the interface could resolve this issue. We assess the wide band gap semiconductor, CdTe, as a candidate material to mediate the coupling at the lattice-matched interface between α-Sn and InSb. To this end, we use density functional theory (DFT) with Hubbard U corrections, whose values are machine-learned via Bayesian optimization (BO) [ npj Computational Materials 2020, 6, 180]. The results of DFT+U(BO) are validated against angle resolved photoemission spectroscopy (ARPES) experiments for α-Sn and CdTe. For CdTe, the z-unfolding method [ Advanced Quantum Technologies 2022, 5, 2100033] is used to resolve the contributions of different kz values to the ARPES. We then study the band offsets and the penetration depth of metal-induced gap states (MIGS) in bilayer interfaces of InSb/α-Sn, InSb/CdTe, and CdTe/α-Sn, as well as in trilayer interfaces of InSb/CdTe/α-Sn with increasing thickness of CdTe. We find that 16 atomic layers (3.5 nm) of CdTe can serve as a tunnel barrier, effectively shielding the InSb from MIGS from the α-Sn. This may guide the choice of dimensions of the CdTe barrier to mediate the coupling in semiconductor-superconductor devices in future Majorana zero modes experiments.

13.
Opt Express ; 20(4): 4102-13, 2012 Feb 13.
Artigo em Inglês | MEDLINE | ID: mdl-22418168

RESUMO

Coherent pulse interleaving implemented in planar waveguide technology is presented as a compact and robust solution to generate high repetition rate frequency combs. We demonstrate a 10 GHz pulse train from an Er-doped femtosecond fiber laser that is coupled into waveguide interleavers and multiplied in repetition rate by a factor of 16. With thermal tuning of the chip elements, we achieve optical and RF sidemode suppression levels of at least -30 dB.

14.
Micromachines (Basel) ; 13(9)2022 Sep 19.
Artigo em Inglês | MEDLINE | ID: mdl-36144176

RESUMO

A compressible medium represented by pure water saturated by small nonreactive or reactive gas bubbles can be used for generating a propulsive force in large-, medium-, and small-scale thrusters referred to as a pulsed detonation hydroramjet (PDH), which is a novel device for underwater propulsion. The PDH thrust is produced due to the acceleration of bubbly water (BW) in a water guide by periodic shock waves (SWs) and product gas jets generated by pulsed detonations of a fuel-oxidizer mixture. Theoretically, the PDH thrust is proportional to the operation frequency, which depends on both the SW velocity in BW and pulsed detonation frequency. The studies reported in this manuscript were aimed at exploring two possible directions of the improvement of thruster performances, namely, (1) the replacement of chemically nonreacting gas bubbles by chemically reactive ones, and (2) the increase in the pulsed detonation frequency from tens of hertz to some kilohertz. To better understand the SW-to-BW momentum transfer, the interaction of a single SW and a high-frequency (≈7 kHz) sequence of three SWs with chemically inert or active BW containing bubbles of air or stoichiometric acetylene-oxygen mixture was studied experimentally. Single SWs and SW packages were generated by burning or detonating a gaseous stoichiometric acetylene-oxygen or propane-oxygen mixture and transmitting the arising SWs to BW. The initial volume fraction of gas in BW was varied from 2% to 16% with gas bubbles 1.5-4 mm in diameter. The propagation velocity of SWs in BW ranged from 40 to 580 m/s. In experiments with single SWs in chemically active BW, a detonation-like mode of reaction front propagation ("bubbly quasidetonation") was realized. This mode consisted of a SW followed by the front of bubble explosions and was characterized by a considerably higher propagation velocity as compared to the chemically inert BW. The latter could allow increasing the PDH operation frequency and thrust. Experiments with high-frequency SW packages showed that on the one hand, the individual SWs quickly merged, feeding each other and increasing the BW velocity, but on the other hand, the initial gas content for each successive SW decreased and, accordingly, the SW-to-BW momentum transfer worsened. Estimates showed that for a small-scale water guide 0.5 m long, the optimal pulsed detonation frequency was about 50-60 Hz.

15.
Adv Sci (Weinh) ; 9(12): e2105722, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35182039

RESUMO

Indium antimonide (InSb) nanowires are used as building blocks for quantum devices because of their unique properties, that is, strong spin-orbit interaction and large Landé g-factor. Integrating InSb nanowires with other materials could potentially unfold novel devices with distinctive functionality. A prominent example is the combination of InSb nanowires with superconductors for the emerging topological particles research. Here, the combination of the II-VI cadmium telluride (CdTe) with the III-V InSb in the form of core-shell (InSb-CdTe) nanowires is investigated and potential applications based on the electronic structure of the InSb-CdTe interface and the epitaxy of CdTe on the InSb nanowires are explored. The electronic structure of the InSb-CdTe interface using density functional theory is determined and a type-I band alignment is extracted with a small conduction band offset ( ⩽0.3 eV). These results indicate the potential application of these shells for surface passivation or as tunnel barriers in combination with superconductors. In terms of structural quality, it is demonstrated that the lattice-matched CdTe can be grown epitaxially on the InSb nanowires without interfacial strain or defects. These shells do not introduce disorder to the InSb nanowires as indicated by the comparable field-effect mobility measured for both uncapped and CdTe-capped nanowires.

16.
Micromachines (Basel) ; 13(11)2022 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-36422462

RESUMO

Triethylaluminum Al(C2H5)3, TEA, and triethylborane, B(C2H5)3, TEB, are transparent, colorless, pyrophoric liquids with boiling points of approximately 190 °C and 95 °C, respectively. Upon contact with ambient air, TEA, TEB, as well as their mixtures and solutions, in hydrocarbon solvents, ignite. They can also violently react with water. TEA and TEB can be used as hypergolic rocket propellants and incendiary compositions. In this manuscript, a novel scheme of the heterogeneous interaction of gaseous oxygen with liquid TEA/TEB microdroplets accompanied by the release of light hydrocarbon radicals into the gas phase is used for calculating the self-ignition of a spatially homogeneous mixture of fuel microdroplets in ambient air at normal pressure and temperature (NPT) conditions. In the primary initiation step, TEA and TEB react with oxygen, producing an ethyl radical, which can initiate an autoxidation chain. The ignition delay is shown to decrease with the decrease in the droplet size. Preliminary experiments on the self-ignition of pulsed and continuous TEA-TEB sprays in ambient air at NPT conditions are used for estimating the Arrhenius parameters of the rate-limiting reaction. Experiments confirm that the self-ignition delay of TEA-TEB sprays decreases with the injection pressure and provide the data for estimating the activation energy of the rate-limiting reaction, which appears to be close to 2 kcal/mol.

17.
Biomed Tech (Berl) ; 64(3): 275-284, 2019 May 27.
Artigo em Inglês | MEDLINE | ID: mdl-29935108

RESUMO

The presence of high-frequency velocity fluctuations in aneurysms have been confirmed by in-vivo measurements and by several numerical simulation studies. Only a few studies have located and recorded wall vibrations in in-vitro experiments using physiological patient models. In this study, we investigated the wall fluctuations produced by a flowing perfusion fluid in a true-to-scale elastic model of a cerebral fusiform aneurysm using a laser Doppler vibrometer (LDV). The model was obtained from patient data. The experimental setup reproduced physiologically relevant conditions using a compliant perfusion system, physiological flow parameters, unsteady flow and a non-Newtonian fluid. Three geometrically identical models with different wall elasticities were used for measurements. The influence of five different flow rates was considered. Wall vibrations were predominantly found at frequencies in the range 40-60 Hz and 255-265 Hz. Their amplitude increased with increasing elasticity of the model, but the spectral peaks remained at about the same frequency. Varying the flow rate produced almost no changes in the frequency domain of the models. The frequency of the spectral peaks varied slightly between points at the lateral wall and at the bottom of the aneurysm. Indeed, embedding the model in a fluid during measurements produced higher and smoother amplitude fluctuations.


Assuntos
Velocidade do Fluxo Sanguíneo/fisiologia , Elasticidade/fisiologia , Aneurisma Intracraniano/fisiopatologia , Simulação por Computador , Humanos , Vibração
18.
World Neurosurg ; 122: e577-e583, 2019 02.
Artigo em Inglês | MEDLINE | ID: mdl-31108073

RESUMO

BACKGROUND: Flow diverter stents have become a useful tool for treatment of complex intracranial aneurysms. A serious complication is incomplete wall apposition after flow diverter placement. The aim of this study was to present a comprehensive investigation of hemodynamic changes induced by incomplete expansion of a flow diverter. METHODS: A case of a patient treated for an internal carotid artery aneurysm by flow diversion with incomplete wall apposition was virtually investigated. The effect of incomplete flow diverter expansion was studied using image-based blood flow simulations under physiologically relevant flow conditions based on patient-specific clinical data. RESULTS: The numerical results revealed that incomplete expansion at the proximal end of the stent had minimal impact on the intra-aneurysmal blood flow alteration. A region of nonphysiologically high wall shear stress was observed near the contact area between the incompletely expanded proximal end of the flow diverter and the parent artery, which caused an intimal hyperplasia in this region. These simulation results were consistent with the real-life clinical course and outcome. CONCLUSIONS: The results of this study can be considered during treatment planning of complex cases where the risk of incomplete flow diverter expansion exists. Further studies are required before results can also be used to support the decision process about antiplatelet therapy and additional interventions to improve wall apposition.


Assuntos
Doenças das Artérias Carótidas/terapia , Embolização Terapêutica/efeitos adversos , Aneurisma Intracraniano/terapia , Túnica Íntima/patologia , Velocidade do Fluxo Sanguíneo/fisiologia , Prótese Vascular/efeitos adversos , Doenças das Artérias Carótidas/fisiopatologia , Artéria Carótida Interna , Embolização Terapêutica/instrumentação , Hemodinâmica/fisiologia , Humanos , Hiperplasia/etiologia , Hiperplasia/fisiopatologia , Aneurisma Intracraniano/fisiopatologia , Pessoa de Meia-Idade , Modelos Biológicos , Stents/efeitos adversos , Telas Cirúrgicas
19.
Front Mar Sci ; 6: 391, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31534949

RESUMO

Developments in observing system technologies and ocean data assimilation (DA) are symbiotic. New observation types lead to new DA methods and new DA methods, such as coupled DA, can change the value of existing observations or indicate where new observations can have greater utility for monitoring and prediction. Practitioners of DA are encouraged to make better use of observations that are already available, for example, taking advantage of strongly coupled DA so that ocean observations can be used to improve atmospheric analyses and vice versa. Ocean reanalyses are useful for the analysis of climate as well as the initialization of operational long-range prediction models. There are many remaining challenges for ocean reanalyses due to biases and abrupt changes in the ocean-observing system throughout its history, the presence of biases and drifts in models, and the simplifying assumptions made in DA solution methods. From a governance point of view, more support is needed to bring the ocean-observing and DA communities together. For prediction applications, there is wide agreement that protocols are needed for rapid communication of ocean-observing data on numerical weather prediction (NWP) timescales. There is potential for new observation types to enhance the observing system by supporting prediction on multiple timescales, ranging from the typical timescale of NWP, covering hours to weeks, out to multiple decades. Better communication between DA and observation communities is encouraged in order to allow operational prediction centers the ability to provide guidance for the design of a sustained and adaptive observing network.

20.
Int J Comput Assist Radiol Surg ; 14(10): 1795-1804, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31054128

RESUMO

PURPOSE: Assessing the rupture probability of intracranial aneurysms (IAs) remains challenging. Therefore, hemodynamic simulations are increasingly applied toward supporting physicians during treatment planning. However, due to several assumptions, the clinical acceptance of these methods remains limited. METHODS: To provide an overview of state-of-the-art blood flow simulation capabilities, the Multiple Aneurysms AnaTomy CHallenge 2018 (MATCH) was conducted. Seventeen research groups from all over the world performed segmentations and hemodynamic simulations to identify the ruptured aneurysm in a patient harboring five IAs. Although simulation setups revealed good similarity, clear differences exist with respect to the analysis of aneurysm shape and blood flow results. Most groups (12/71%) included morphological and hemodynamic parameters in their analysis, with aspect ratio and wall shear stress as the most popular candidates, respectively. RESULTS: The majority of groups (7/41%) selected the largest aneurysm as being the ruptured one. Four (24%) of the participating groups were able to correctly select the ruptured aneurysm, while three groups (18%) ranked the ruptured aneurysm as the second most probable. Successful selections were based on the integration of clinically relevant information such as the aneurysm site, as well as advanced rupture probability models considering multiple parameters. Additionally, flow characteristics such as the quantification of inflow jets and the identification of multiple vortices led to correct predictions. CONCLUSIONS: MATCH compares state-of-the-art image-based blood flow simulation approaches to assess the rupture risk of IAs. Furthermore, this challenge highlights the importance of multivariate analyses by combining clinically relevant metadata with advanced morphological and hemodynamic quantification.


Assuntos
Aneurisma Roto/diagnóstico , Angiografia Cerebral , Aneurisma Intracraniano/diagnóstico , Modelos Cardiovasculares , Aneurisma Roto/fisiopatologia , Angiografia Cerebral/métodos , Circulação Cerebrovascular/fisiologia , Biologia Computacional , Hemodinâmica/fisiologia , Humanos , Aneurisma Intracraniano/fisiopatologia , Medição de Risco , Fatores de Risco
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