[The influence of hormonal therapy on the development of rhinitis in the pregnant women].

The objective of the present study was to evaluate the influence of hormonal therapy used to correct the hormonal status of the pregnant women during different periods of gestation on the development of the nasal obstruction symptoms. A total of 53 case histories of the pregnant women (urban residents) were available for the analysis. In 2012, all the patients were under observation of an obstetrician-gyneciologist based at an outpatient setting. 16 of them (30.2%) suffered stuffness in the nose that was especially well pronounced during the II and III trimesters (37.5% in each trimester). Mild stuffness predominated over the moderate and strong ones (62.5, 18.75 and 18.75% respectively). The disturbed hormonal status was documented in 13 (81.75%) pregnant women in the form of reduced progesterone and human CG-beta levels and increased serum DHEA-C concentration. The hormonal status was corrected during the I and II trimesters. The women having very high serum DHEA-C concentration were treated with metypred; those with the low progesterone level were given utrogestan. In both groups, the diseases was especially well manifested in the early II trimester. It is conjectured that therapy with the use of progesterone and glucocorticoid-based preparations had no appreciable effect on the development of rhinitis in the pregnant women.

[Comparative efficacy of etiotropic therapy of patients with HBeAg-positive chronic hepatitis B (by the data of the international comparative placebo-controlled study)].

Comparative placebo-controlled study entrolled 647 patients with verified diagnosis of chronic virus hepatitis B (HBeAg+), not previously subjected to antiviral therapy (with nucleotide analogues or interferons). The drug under the investigation was cycloferon, an earlier interferon inductor. The antiviral combination therapy of the main group patients (323 subjects) included the use of cycloferon + lamivudine for 48 weeks and the therapy of the control group patients (324 subjects) included the use of lamivudine + placebo for 48 weeks. The cycloferon and lamividine combination antiviral therapy was shown preferable vs. the lamivudine + placebo therapy by biochemical remission, virusological response, seroconversion by HBeAg by the 48th week of the treatment and HBsAg clearance. The conbination therapy provided lower frequency of the relapses within 24 weeks of the observation. The higher efficacy of the antiviral combination therapy was evident of the impact of the antiviral activity of cycloferon itself and its immunomodulating and interferon-inducing activity on elimination of the virus-infected hepatocytes. The use of the 48-week course of the antiviral combination therapy is advisable as the prime treatment in the management of patients with HBeAg-positive chronic hepatitis not previously treated with nucleoside analogues and as a variant of therapy for lamivudine-refractory patients.

[Efficacy of reamberin for the treatment of acute intestinal infections caused by opportunistic bacteria].

Reamberin was shown to improve the efficacy of the treatment of acute intestinal infections caused by opportunistic bacteria. Its introduction into combined therapy accelerated normalization of the patients' general conditions, improved their well-being, eliminated syndrome of infectious toxicosis, diarrheic and abdominal pain syndromes, decreased duration of postinfectious asthenia, had beneficial effect on biochemical and immune parameters. Reamberin reduced the level of medium-sized molecules and malonic dialdehyde to the upper normal value which suggests elimination of endogenous "metabolic" intoxication syndrome, normalization of the level of circulating immune complexes and their fractional composition. The study showed that introduction of reamberin in combined therapy of acute intestinal infections is pathogenetically justified.

[Estimation of clinical-pathogenetic efficiency of reamberin and cycloferon application in patients with the severe form of acute tonsillitis].

Efficiency of reamberin and cycloferon application combination at the patients with the heavy form of acute tonsillitis was investigated. It is set that cycloferon and reamberin application in the complex of treatment of the patients with this pathology is instrumental in normalization of the general state and feel of patients, liquidation of both commontoxic syndrome and local inflammatory displays in pharynx, and also normalization of the studied biochemical and immunological indexes. Application of cycloferon and reamberin provides the decline of "average molecules" and malon dialdehyde level to norm, that testifies about liquidation endogenous "metabolic" intoxication syndrome, and also instrumental in normalization of phagocytes activity of monocytes indexes, that describe normalize operating of the indicated preparation on the macrophage phagocytes system.

[Clinical efficiency of reamberin - cycloferon combination in treatment of hepatic cirrhosis associated with chronic HCV infection].

The clinical efficiency of a reamberin and cycloferon combination for the treatment of hepatic cirrhosis (HC) associated with chronic HCV infection has been studied. Immunological investigation of patients carried out before the treatment revealed a significant increase in the level of proinflammatory cytokines (CK) in serum, whereas the level of anti-inflammatory CK changed rather insignificantly. Use of the reamberin - cycloferon combination provided faster clinical-biochemical remission and, in respect of the pathogenetic state, ensured normalization of the CK profile in the blood. Based on these data, it can be considered as pathogenetically proved and clinically feasible and promising to use the reamberin - cycloferon combinations for a complex treatment of patients with HC associated with chronic HCV-infection.

[Efficacy of combined immunocorrection in the treatment of chronic viral hepatitis C].

AIM: To assess efficacy of combined immunocorrection in the treatment of patients with chronic viral hepatitis C (CVHC). MATERIAL AND METHODS: Routine clinicobiochemical tests, examination of immunological homeostasis (cellular immunity, the level of circulating immune complexes - CIC and their molecular composition, macrophagal phagocyting system - MPS) were made in two groups of CVHC patients: the study group (n=68) and control group (n=66). The control patients received standard treatment, the study group received also cyclopheron in combination with reamberin. Cyclopheron was given per os in a single daily dose 600 mg 2 days, then 3 times a week in a dose 150 mg for 48 weeks. Reamberin infusions in a single daily dose 400 ml were made for 5 - 7 days. RESULTS: CVHC in exacerbation phase is characterized by the presence of secondary immunodeficiency running with T-lymphopenia, low count of peripheral blood lymphocytes with CD4+ phenotype and low immunoregulatory index CD4/CD8, depression of functional activity of T-cells as evidenced by lymphocyte blast transformation test with phytohemagglutinin, inhibition of phagocyting activity of monocytes and inhibition of dermal macrophages. This shows subnormal functional activity of MPS. CVHC runs with accumulation of CIC in blood serum primarily due to increased content of most pathogenic mid- and low-molecular .ifactions of immune complexes. Addition ofcyclopheron and reamberin in combined treatment of CVHC patients promotes normalization of immunological homeostasis which clinically occurs in parallel with achievement of persistent and long-term CVHC remission. CONCLUSION: The results of the above investigation support pathogenetic validity and prospects of cyclopheron and reamberin inclusion into combined treatment of CVHC.

[Increase of antibacterial therapy efficacy in chronic sepsis with cycloferon and reamberin combination].

The use of reamberin and cycloferon combination for increasing the antibacterial therapy efficacy in patients with chronic sepsis (CS) was studied. It was shown that the combination provided more rapid elimination of the CS exacerbation symptoms, normalization of the hematologic indices, bacteriemia eradication and reduction of the cytokine blood profile--normal serum levels of proinflammatory (IL-1beta, IL-2, IL-6 and TNF-alpha) and antiinflammatory (IL-4) cytokines. The findings allowed to considered the use of the reamberin and cycloferon combination in the treatment of patients with CS pathogenetically reasonable and clinically perspective for increasing the antibacterial therapy efficacy.

[Diagnostics and treatment of coronary heart disease and concomitant climacteric cardiopathy].

To improve differential diagnostics and treatment of coronary heart diseases (CHD) and concomitant climacteric cardiopathy (CCP), we analysed results of clinical examination and laboratory-instrumental studies of 1063 women complaining of chest pain. They were divided in 3 groups: group 1 (817 patients with CHD), group 2 (134 patients with CCP), group 3 (122 patients with CHD+CCP). Peculiarities of laboratory and instrumental diagnostics are described in conjunction with comparative characteristic of multispiral CT coronarography and corononaroangiography.

[Efficiency of enterosorbent White Coal in the treatment of the patients with chronic viral hepatitis C and its influence on lipoperoxidation markers and endogenous intoxication in blood of patients].

Efficiency of enterosorbent White Coal (aerosil) at the treatment of the patients with chronic viral hepatitis C (CVHC) was investigated. It was set that including of enterosorbent White Coal (aerosil) to the complex treatment of the patients with CVHC provided more fast liqudation clinical symptoms and provided archievment of clinical-biochemical remission and at pathogenetic plan--decrease of concentration "average molecules" and lipoperoxidation's products in the serum that testified about liqudation "metabolic intoxication" and oxidative stress syndromes.

[Influence of immunotropic preparation cycloferon and phytopreparations of Cynara scolimus L. on blood cytokines profile of the patients with chronic viral hepatitis C in medical rehabilitation period].

The effect of the immunotropic drug cycloferon and herbal medicine resources on the basis of Cynara scolimus L. on the blood cytokine profile in the patients with chronic viral hepatitis C (CVHC) in medical rehabilitation (MR) period. Established that prior to MR period in the patients with CVHC was noted significantly increased levels of proinflammatory cytokines (CK) at the blood serum, and the level of antiinflammatory CK changed significantly. The use of cycloferon and herbal medicine resources on the basis of Cynara scolimus L. in the MR complex provided to normalize the studied CK concentration in the serum of the patients with CVHC.

[Efficiency of enterosorbent white coal* in the treatment of patients with hepatic cirrhosis].

Efficiency of enterosorbent White Coal (aerosil) at the treatment of the patients with hepatic cirrhosis (HC) was investigated. It was set that including of enterosorbent White Coal to the complex treatment of the patients with HC provided more fast liqudation clinical symptoms and provided archievment of clinical-biochemical remission and at pathogenetic plan - decrease of concentration "average molecules", lipoperoxidation's products, increase of antioxydant system enzymes in the serum that testified about liqudation "metabolic intoxication" and oxidative stress syndromes.

[Effectiveness of Reamberin in correction of oxidative stress syndrome in patients with phlegmonous and gangrenous erysipelas against the background of the 2 type diabetes mellitus].

The influence of modern detoxic preparation Reamberin on indicators of oxidative stress syndrome (OSS)--the content of lipoperoxidation products was investigated. It was established that inclusion of Reamberin in the complex of surgical treatment of destructive forms of erysipelas on the background of type 2 DM accelerates the liquidation of OSS.

[Correction of the immunity disorders in patients while surgical treatment of coexistant gastroduodenal ulcers].

There were examined 64 patients, suffering combined gastroduodenal ulcers. Subpopulations of lymphocytes, using monoclonal antibodies, were used to estimate the patients immune status. The investigation was performed in a dynamics: immediately after admittance to hospital, on the operation day and on the tenth postoperative day. In 33 patients (the main group) reamberin was applied in a complex of surgical treatment and in 31 (the comparison group)--the conventional medicinal preparations. In all the patients before the treatment conduction there were revealed the cell immunity chain disorders like in a secondary immune deficiency state (SIDS). The SIDS elimination and the immunological indices improvement were promoted by incorporation of reamberin in the complex of surgical treatment.

[Influence of сycloferon on the сytokine blood profile and production of proinflammatory сytokines in the cultures of mononucleares of peripheral blood of the patients with chronic tonsillitis].

The 88 patients with chronic tonsillitis (CT) was investigated. The 46 patients (basic group) got the modern immunoactive preparation cycloferon and 42 patients (comparison group) - only the generally accepted therapy. During immunological researches on a background clinical manifestation of СT the increase proinflammatory cytokines (CK) (TNFα, IL-1Β) in the serum, and also increase the level of spontaneous products of these CK in the cultures mononucleares of periferal blood was detected. At general accepted treatment took place increase level proinflammatory CK at serum on background decline stimulated product of CK at mononucleares cultures. Aрplication of cycloferon at the treatment of CT provided to normalization cytokines profile of the blood and production of CK in the cultures mononucleares.

[Efficiency of cycloferon and reamberin combination at the treatment of the patients with chronic sepsis].

The cytokine profile of blood (CPB) at the patients with chronic sepsis (CS) streptococcus or mixed (by a streptococcus and to staphylococcus etiology) was studied. To beginning of the treatment at intensifying of CS at the patients was detected the substantial increase of maintenance of proinflammatory (IL - 1ß, IL - 2, IL - 6, TNF -α) cytokines (CК) in the blood serum at the moderate increase of antiinflammatory CK (IL-4). Thus, indexes, characterizing correlation pro- and antiinflammatory CК was rate, that testified to predominating of proinflammatory potencies of blood. Application in the complex treatment of the patients with CS combination of modern detoxic preparation reamberin and immunoactive preparation cycloferon promotes normalizations of CK maintenance in the blood and betweennesss by them. In a clinical plan the use of the reamberin and cycloferon combination provided acceleration of CS intensifying liquidation. Finding allow to consider pathogenetic reasonable and clinically perspective application of this preparations combination in treatment of the patients with CS.

[Pathogenetic ground of including reamberin and cycloferon combination into the therapy program for patients with severe cases of acute tonsillitis of a mixed viral/bacterial etiology].

The increase of severe cases of acute tonsillitis (AT) is presently marked. Severe cases of AT disturb immune and metabolic homoeostasis initiating the development of disease. Therapy optimization is required to select the best treatment. In patients with severe cases of AT of mixed viral/bacterial etiology before the treatment it is revealed the increase of general activity of lactatedehydrigenase (LDH) and increase of the level of cathode "anaerobic" factions LDH4+5 and the decline of concentration ATP in the blood. There was a compensatory rise of level of ADP and АМP. The substantial decline of serum interferon (CIF) activity and diminishing maintenance of α-interferon (α-IFN) and γ-interferon (γ-IFN) in the blood of the patients, that testified to oppressing of interferonogenesis. Treatment of severe cases of AT of mixed viral/bacterial etiology of modern detoxic preparation reamberin and immunoactive preparation cycloferon combination positively influences the studied laboratory indexes. The improvement of power metabolism is marked, that was characterized by normalization of level adenine nucleotides (ATP, АDP, АМP) and general activity of LDH and its izoenzimes spectrum. At the same time the increase of CIF level is set, maintenances α-IFN and γ-IFN in the blood, that testified to the improvement of interferonogenesis. The results demonstrate the therapeutic potential of reamberin and cycloferon combination for treatment of patients with AT of mixed viral/bacterial etiology.

[Estimation of efficiency reamberin in the correction of endogenous intoxication syndrome at the patients with the phlegmonous and gangrenous forms of erysipelas on background diabetes mellitus at their surgical treatment].

The influence of modern detoxic preparation reamberin on indicators of the of endogenous intoxication syndrome (EIS)--the level of average molecules, malon dialdehyde, cyrcukatiry immune complexes and its fractional composition in blood serum of the patients with destructive forms of erysipelas--phlegmonous and gangrenous on background diabetes mellitus (DM). It is established that the inclusion of reamberin in the complex surgical treatment of destructive forms of erysipelas on background DM accelerates the elimination of SEI. From this we can recommend the use of reamberin in the complex surgical treatment of complicated forms of erysipelas on background DM.

[Efficiency of modern immunoactive preparation cycloferon at coplex therapy of the patients with nonalcoholic steatohepatitis combined with irritable bowel syndrome].

The efficiency of modern immunoactive preparation cycloferon at coplex therapy of the patients with nonalcoholic steatohepatitis (NASH) combined with irritable bowel syndrome (IBS). It was set that before treatment took place devition of immune homeostasis such as cellular immunity and serum interferon activity. Application of cycloferon provided to regress of clinical symptoms of NASH, combined with IBS and normalization of immune indexes.

[Effectivity of detoxification preparation reamberin in complex treatment of the patients with chronic cholecystitis combined with chronic pancreatitis on background of HCV-infection].

Effectivity of detoxic preparation reamberin at complex treatment of the patients with acuting of chronic cholecystitis combined with chronic pancreatitis on background of HCV-infection was detected. It was set that before treatment took place increase "average molecules", lipid peroxidation products--malondialdehyde and dien conjugates and increase of circulatory immune complexes in serum. Including of reamberin provided to normalization clinical-biochemical indexes.

[Influence of dentoalveolar pathology on the efficiency of conservative treatment of chronic suppurative otitis].

The study was designed to analyse immunoreactivity in patients with chronic suppurative otitis and results of its treatment. A separate group was comprised of patients with dentoalveolar pathology. It is concluded that the efficacy of therapy of chronic suppurative otitis depends on the presence of concomitant dentoalveolar abscess and carious lesions.