Pesquisa | BVS Violência e Saúde

1.

Characterisation of Ppy-lineage cells clarifies the functional heterogeneity of pancreatic beta cells in mice.

Fukaishi, Takahiro; Nakagawa, Yuko; Fukunaka, Ayako; Sato, Takashi; Hara, Akemi; Nakao, Keiko; Saito, Michiko; Kohno, Kenji; Miyatsuka, Takeshi; Tamaki, Motoyuki; Matsuhisa, Munehide; Matsuoka, Taka-Aki; Yamada, Tetsuya; Watada, Hirotaka; Fujitani, Yoshio.

Diabetologia ; 64(12): 2803-2816, 2021 12.

Artigo em Inglês | MEDLINE | ID: mdl-34498099

2.

Detailed analyses of the crucial functions of Zn transporter proteins in alkaline phosphatase activation.

Suzuki, Eisuke; Ogawa, Namino; Takeda, Taka-Aki; Nishito, Yukina; Tanaka, Yu-Ki; Fujiwara, Takashi; Matsunaga, Mayu; Ueda, Sachiko; Kubo, Naoya; Tsuji, Tokuji; Fukunaka, Ayako; Yamazaki, Tomohiro; Taylor, Kathryn M; Ogra, Yasumitsu; Kambe, Taiho.

J Biol Chem ; 295(17): 5669-5684, 2020 04 24.

Artigo em Inglês | MEDLINE | ID: mdl-32179649

3.

Leukotriene A₄ hydrolase deficiency protects mice from diet-induced obesity by increasing energy expenditure through neuroendocrine axis.

Uzawa, Hirotsugu; Kohno, Daisuke; Koga, Tomoaki; Sasaki, Tsutomu; Fukunaka, Ayako; Okuno, Toshiaki; Jo-Watanabe, Airi; Kazuno, Saiko; Miyatsuka, Takeshi; Kitamura, Tadahiro; Fujitani, Yoshio; Watada, Hirotaka; Saeki, Kazuko; Yokomizo, Takehiko.

FASEB J ; 34(10): 13949-13958, 2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-32844470

4.

Rubicon in pancreatic beta cells plays a limited role in maintaining glucose homeostasis following increased insulin resistance.

Aoyama, Shuhei; Nishida, Yuya; Fujitani, Yoshio; Fukunaka, Ayako; Miyatsuka, Takeshi; Suzuki, Luka; Himuro, Miwa; Yoshimori, Tamotsu; Watada, Hirotaka.

Endocr J ; 67(11): 1119-1126, 2020 Nov 28.

Artigo em Inglês | MEDLINE | ID: mdl-32669482

5.

Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-ß expression.

Fukunaka, Ayako; Fukada, Toshiyuki; Bhin, Jinhyuk; Suzuki, Luka; Tsuzuki, Takamasa; Takamine, Yuri; Bin, Bum-Ho; Yoshihara, Toshinori; Ichinoseki-Sekine, Noriko; Naito, Hisashi; Miyatsuka, Takeshi; Takamiya, Shinzaburo; Sasaki, Tsutomu; Inagaki, Takeshi; Kitamura, Tadahiro; Kajimura, Shingo; Watada, Hirotaka; Fujitani, Yoshio.

PLoS Genet ; 13(8): e1006950, 2017 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-28854265

6.

Normal pancreatic ß-cell function in mice with RIP-Cre-mediated inactivation of p62/SQSTM1.

Honda, Akira; Komiya, Koji; Hara, Akemi; Fukunaka, Ayako; Suzuki, Luka; Miyatsuka, Takeshi; Ogihara, Takeshi; Fujitani, Yoshio; Watada, Hirotaka.

Endocr J ; 65(1): 83-89, 2018 Jan 30.

Artigo em Inglês | MEDLINE | ID: mdl-28978813

7.

Role of Zinc Homeostasis in the Pathogenesis of Diabetes and Obesity.

Fukunaka, Ayako; Fujitani, Yoshio.

Int J Mol Sci ; 19(2)2018 Feb 06.

Artigo em Inglês | MEDLINE | ID: mdl-29415457

8.

The PP-motif in luminal loop 2 of ZnT transporters plays a pivotal role in TNAP activation.

Fujimoto, Shigeyuki; Tsuji, Tokuji; Fujiwara, Takashi; Takeda, Taka-Aki; Merriman, Chengfeng; Fukunaka, Ayako; Nishito, Yukina; Fu, Dax; Hoch, Eitan; Sekler, Israel; Fukue, Kazuhisa; Miyamae, Yusaku; Masuda, Seiji; Nagao, Masaya; Kambe, Taiho.

Biochem J ; 473(17): 2611-21, 2016 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-27303047

9.

[Zinc and type 2 diabetes].

Fukunaka, Ayako; Fujitani, Yoshio.

Nihon Rinsho ; 74(7): 1132-7, 2016 Jul.

Artigo em Japonês | MEDLINE | ID: mdl-27455802

10.

Possible involvement of zinc transporter ZIP13 in myogenic differentiation.

Shoji, Masaki; Ohashi, Takuto; Nagase, Saki; Yuri, Haato; Ichihashi, Kenta; Takagishi, Teruhisa; Nagata, Yuji; Nomura, Yuki; Fukunaka, Ayako; Kenjou, Sae; Miyake, Hatsuna; Hara, Takafumi; Yoshigai, Emi; Fujitani, Yoshio; Sakurai, Hidetoshi; Dos Santos, Heloísa G; Fukada, Toshiyuki; Kuzuhara, Takashi.

Sci Rep ; 14(1): 8052, 2024 04 12.

Artigo em Inglês | MEDLINE | ID: mdl-38609428

11.

Protective Effects of Imeglimin and Metformin Combination Therapy on ß-Cells in db/db Male Mice.

Nishiyama, Kuniyuki; Ono, Masato; Tsuno, Takahiro; Inoue, Ryota; Fukunaka, Ayako; Okuyama, Tomoko; Kyohara, Mayu; Togashi, Yu; Fukushima, Setsuko; Atsumi, Takuto; Sato, Aoi; Tsurumoto, Asuka; Sakai, Chisato; Fujitani, Yoshio; Terauchi, Yasuo; Ito, Shuichi; Shirakawa, Jun.

Endocrinology ; 164(8)2023 06 26.

Artigo em Inglês | MEDLINE | ID: mdl-37314160

12.

Zinc and iron dynamics in human islet amyloid polypeptide-induced diabetes mouse model.

Fukunaka, Ayako; Shimura, Mari; Ichinose, Takayuki; Pereye, Ofejiro B; Nakagawa, Yuko; Tamura, Yasuko; Mizutani, Wakana; Inoue, Ryota; Inoue, Takato; Tanaka, Yuto; Sato, Takashi; Saitoh, Tatsuya; Fukada, Toshiyuki; Nishida, Yuya; Miyatsuka, Takeshi; Shirakawa, Jun; Watada, Hirotaka; Matsuyama, Satoshi; Fujitani, Yoshio.

Sci Rep ; 13(1): 3484, 2023 03 15.

Artigo em Inglês | MEDLINE | ID: mdl-36922503

13.

Tissue nonspecific alkaline phosphatase is activated via a two-step mechanism by zinc transport complexes in the early secretory pathway.

Fukunaka, Ayako; Kurokawa, Yayoi; Teranishi, Fumie; Sekler, Israel; Oda, Kimimitsu; Ackland, M Leigh; Faundez, Victor; Hiromura, Makoto; Masuda, Seiji; Nagao, Masaya; Enomoto, Shuichi; Kambe, Taiho.

J Biol Chem ; 286(18): 16363-73, 2011 May 06.

Artigo em Inglês | MEDLINE | ID: mdl-21402707

14.

Establishment of an enzyme-linked immunosorbent assay for mouse pancreatic polypeptide clarifies the regulatory mechanism of its secretion from pancreatic Î³ cells.

Saito, Daisuke; Nakagawa, Yuko; Sato, Takashi; Fukunaka, Ayako; Pereye, Ofejiro Blessing; Maruyama, Nobuhiro; Watada, Hirotaka; Fujitani, Yoshio.

PLoS One ; 17(8): e0269958, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-35976945

15.

Demonstration and characterization of the heterodimerization of ZnT5 and ZnT6 in the early secretory pathway.

Fukunaka, Ayako; Suzuki, Tomoyuki; Kurokawa, Yayoi; Yamazaki, Tomohiro; Fujiwara, Naoko; Ishihara, Kaori; Migaki, Hitoshi; Okumura, Katsuzumi; Masuda, Seiji; Yamaguchi-Iwai, Yuko; Nagao, Masaya; Kambe, Taiho.

J Biol Chem ; 284(45): 30798-806, 2009 Nov 06.

Artigo em Inglês | MEDLINE | ID: mdl-19759014

16.

Biphasic changes in ß-cell mass around parturition are accompanied by increased serotonin production.

Takahashi, Masaya; Miyatsuka, Takeshi; Suzuki, Luka; Osonoi, Sho; Himuro, Miwa; Miura, Masaki; Katahira, Takehiro; Wakabayashi, Yuka; Fukunaka, Ayako; Nishida, Yuya; Fujitani, Yoshio; Takeda, Satoru; Mizukami, Hiroki; Itakura, Atsuo; Watada, Hirotaka.

Sci Rep ; 10(1): 4962, 2020 03 18.

Artigo em Inglês | MEDLINE | ID: mdl-32188885

17.

[Mechanism of zinc transport by zinc transporters, ZnT and ZIP].

Fukunaka, Ayako; Kambe, Taiho.

Seikagaku ; 82(1): 30-4, 2010 Jan.

Artigo em Japonês | MEDLINE | ID: mdl-20169994

18.

Human IAPP-induced pancreatic ß cell toxicity and its regulation by autophagy.

Shigihara, Nayumi; Fukunaka, Ayako; Hara, Akemi; Komiya, Koji; Honda, Akira; Uchida, Toyoyoshi; Abe, Hiroko; Toyofuku, Yukiko; Tamaki, Motoyuki; Ogihara, Takeshi; Miyatsuka, Takeshi; Hiddinga, Henry J; Sakagashira, Setsuya; Koike, Masato; Uchiyama, Yasuo; Yoshimori, Tamotsu; Eberhardt, Norman L; Fujitani, Yoshio; Watada, Hirotaka.

J Clin Invest ; 124(8): 3634-44, 2014 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-25036706

19.

Molecular pathogenesis of spondylocheirodysplastic Ehlers-Danlos syndrome caused by mutant ZIP13 proteins.

Bin, Bum-Ho; Hojyo, Shintaro; Hosaka, Toshiaki; Bhin, Jinhyuk; Kano, Hiroki; Miyai, Tomohiro; Ikeda, Mariko; Kimura-Someya, Tomomi; Shirouzu, Mikako; Cho, Eun-Gyung; Fukue, Kazuhisa; Kambe, Taiho; Ohashi, Wakana; Kim, Kyu-Han; Seo, Juyeon; Choi, Dong-Hwa; Nam, Yeon-Ju; Hwang, Daehee; Fukunaka, Ayako; Fujitani, Yoshio; Yokoyama, Shigeyuki; Superti-Furga, Andrea; Ikegawa, Shiro; Lee, Tae Ryong; Fukada, Toshiyuki.

EMBO Mol Med ; 6(8): 1028-42, 2014 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-25007800

20.

Essential role of the zinc transporter ZIP9/SLC39A9 in regulating the activations of Akt and Erk in B-cell receptor signaling pathway in DT40 cells.

Taniguchi, Masanari; Fukunaka, Ayako; Hagihara, Mitsue; Watanabe, Keiko; Kamino, Shinichiro; Kambe, Taiho; Enomoto, Shuichi; Hiromura, Makoto.

PLoS One ; 8(3): e58022, 2013.

Artigo em Inglês | MEDLINE | ID: mdl-23505453

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