RESUMO
OBJECTIVE: To investigate the effect of the fermented wheat germ extract (Avemar)in patients with severe rheumatoid arthritis (RA). METHODS: Fifteen female RA (Steinbrocker II-III) patients, who had unsuccessfully tried two different DMARD treatments, were enrolled in an open-label, 1-year long, pilot clinical study. DMARD and steroid therapies were recorded and continued. All patients received Avemar as additional therapy. For measurement of efficacy the Ritchie Index, the Health Assessment Questionnaire (HAQ) and the assessment of morning stiffness were applied. Patients were evaluated at baseline, 6 and 12 months. For statistical analyses the Wilcoxon test was used. RESULTS: At both 6 and 12 months, Ritchie index, HAQ and morning stiffness showed significant improvements compared with the baseline values. Dosages of steroids could be reduced in about half of the patients. No side effects of Avemar were observed. CONCLUSION: Supplementation of standard therapies with a continuous administration of Avemar is beneficial for RA patients.
Assuntos
Artrite Reumatoide/dietoterapia , Extratos Vegetais/administração & dosagem , Triticum , Artrite Reumatoide/fisiopatologia , Suplementos Nutricionais , Feminino , Nível de Saúde , Humanos , Articulações/efeitos dos fármacos , Articulações/fisiopatologia , Projetos Piloto , Índice de Gravidade de Doença , Inquéritos e QuestionáriosRESUMO
We report on two sisters with Perrault's syndrome, i.e., autosomal recessive ovarian dysgenesis associated with sensorineural deafness. They were deaf-mute and of normal height with a few minor somatic anomalies. Both had streak gonads and an apparently normal female 46,XX chromosome constitution. The parents were apparently not consanguineous. The mother had normal hearing. Other relatives were not available for study. Epilepsy, which occurred in three relatives including one of the index patients, may have been inherited coincidentally from the mother's family.
Assuntos
Anormalidades Múltiplas/genética , Surdez/genética , Disgenesia Gonadal/genética , Adolescente , Adulto , Dermatoglifia , Feminino , Genes Recessivos , Humanos , SíndromeRESUMO
In 14 cases of the Turner syndrome and pure gonadal dysgenesis streak gonads were studied histologically. In cases where the 46,XX line was unimpaired the blood vessels of the gonad showed severe degeneration in at least 30 to 50%. These streak gonads usually contained some of the characteristic ovarian elements as well as the vascular lesions. In gonosomal monosomy, on the other hand, a similar intensive vascular degeneration could not be found and the gonad consisted of indeterminate connective tissue. These observations are strong indications of a close correlation between karyotype and the histology of the streak gonad, which may supply further information on the manner and timing of the development of the streak gonad.
Assuntos
Hipogonadismo/patologia , Ovário/patologia , Síndrome de Turner/patologia , Adolescente , Adulto , Artérias/análise , Artérias/patologia , Aberrações Cromossômicas , Transtornos Cromossômicos , Tecido Conjuntivo/patologia , Feminino , Humanos , Hialina/análise , Cariotipagem , Mosaicismo , Folículo Ovariano/patologia , Ovário/irrigação sanguínea , Trombose/patologia , Síndrome de Turner/genéticaRESUMO
The systemic mastocytosis is a rare disorder, however, the authors recently diagnosed two cases causing diagnostic problems. The diagnosis was proved by bone marrow biopsy in both patients. The authors review the diagnostic pathway considering the pitfalls. According to their conclusion, the most important factor in the diagnosis of systemic mastocytosis is to think of the possibility of systemic mastocytosis.