Detalhe da pesquisa
1.
Biomimetic Synthesis of Oleocanthal, Oleacein, and Their Analogues Starting from Oleuropein, A Major Compound of Olive Leaves.
J Nat Prod
; 83(6): 1735-1739, 2020 06 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-32441936
2.
Indirubin Analogues Inhibit Trypanosoma brucei Glycogen Synthase Kinase 3 Short and T. brucei Growth.
Antimicrob Agents Chemother
; 63(6)2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30910902
3.
Evaluation of Dual 5-Lipoxygenase/Microsomal Prostaglandin E2 Synthase-1 Inhibitory Effect of Natural and Synthetic Acronychia-Type Isoprenylated Acetophenones.
J Nat Prod
; 80(3): 699-706, 2017 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28240894
4.
From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity.
Antimicrob Agents Chemother
; 60(5): 2822-33, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26902771
5.
Natural-Based Indirubins Display Potent Cytotoxicity toward Wild-Type and T315I-Resistant Leukemia Cell Lines.
J Nat Prod
; 79(10): 2464-2471, 2016 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27726390
6.
Symphonia globulifera, a widespread source of complex metabolites with potent biological activities.
Planta Med
; 81(2): 95-107, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25590372
7.
Oxidative burst inhibitory and cytotoxic indoloquinazoline and furoquinoline alkaloids from Oricia suaveolens.
J Nat Prod
; 71(11): 1942-5, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18950230
8.
Indirubin derivatives are potent and selective anti-Trypanosoma cruzi agents.
Virulence
; 9(1): 1658-1668, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30387370
9.
6-bromo-indirubin-3'-oxime (6BIO), a Glycogen synthase kinase-3ß inhibitor, activates cytoprotective cellular modules and suppresses cellular senescence-mediated biomolecular damage in human fibroblasts.
Sci Rep
; 7(1): 11713, 2017 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28916781
10.
New semi-synthetic analogs of oleuropein show improved anticancer activity in vitro and in vivo.
Eur J Med Chem
; 137: 11-29, 2017 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28551177
11.
The Indirubin Derivative 6-Bromoindirubin-3'-Oxime Activates Proteostatic Modules, Reprograms Cellular Bioenergetic Pathways, and Exerts Antiaging Effects.
Antioxid Redox Signal
; 27(14): 1027-1047, 2017 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28253732
12.
Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis.
J Med Chem
; 59(19): 8787-8803, 2016 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27617704
13.
Indirubin derivatives: a patent review (2010 - present).
Expert Opin Ther Pat
; 25(5): 583-93, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25887337
14.
An inhibitor-driven study for enhancing the selectivity of indirubin derivatives towards leishmanial Glycogen Synthase Kinase-3 over leishmanial cdc2-related protein kinase 3.
Parasit Vectors
; 7: 234, 2014 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-24886176
15.
Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase.
J Med Chem
; 57(9): 3715-23, 2014 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24697244
16.
Glycogen phosphorylase inhibitors: a patent review (2008 - 2012).
Expert Opin Ther Pat
; 23(8): 1017-32, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23627914
17.
Synthesis of novel guttiferone A derivatives: in-vitro evaluation toward Plasmodium falciparum, Trypanosoma brucei and Leishmania donovani.
Eur J Med Chem
; 65: 284-94, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23727538
18.
Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases.
ACS Med Chem Lett
; 4(1): 22-26, 2013 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-23336033
19.
(WO2011057959) indole and indazole derivatives as glycogen synthase activators: a patent evaluation.
Expert Opin Ther Pat
; 21(12): 1925-9, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21988345
20.
A colorful history: the evolution of indigoids.
Prog Chem Org Nat Prod
; 99: 69-145, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25296438