RESUMO
Haematologic disturbances in 13 cases of gastric cancer are described. All the patients had anemia of different origin. Increased leukocytosis was observed in half of the cases, leukemic reaction in one third. Hemolysis was present in 50% of cases. Thrombocytopenia coexisted most frequently with disseminated intravascular coagulation in 4 patients. Bone metastases were visualised as osteolytic foci with radiological methods or increased capture of isotopic marker in the bones under scintigraphic examination. Under the microscope neoplastic metastases were found in bone marrow smears of 5 patients. All patients displayed symptoms of gastric ulcer disease acute or chronic phase. In some cases only repeated gastroscopic examination and mucosa biopsy was the only way to confirm cancer. In other cases the diagnosis was made after the histopathologic examination of the resected stomach, in still others by a section.
Assuntos
Doenças Hematológicas/etiologia , Neoplasias Gástricas/complicações , Adenocarcinoma/secundário , Adulto , Idoso , Neoplasias da Medula Óssea/patologia , Neoplasias da Medula Óssea/secundário , Neoplasias Ósseas/secundário , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
The modern views on the coexistence of secondary polycythaemia with benign and malignant tumours of varying origin are reviewed describing certain mechanisms determining this association. The diagnostic management of secondary polycythaemia is outlined calling attention to the necessity of ruling out coexistence of a neoplasm.
Assuntos
Adenocarcinoma/sangue , Neoplasias Cerebelares/sangue , Eritropoetina/metabolismo , Hemangiossarcoma/sangue , Neoplasias Renais/sangue , Neoplasias Hepáticas/sangue , Síndromes Paraneoplásicas/etiologia , Policitemia/etiologia , Adenocarcinoma/complicações , Adenocarcinoma/metabolismo , Neoplasias Cerebelares/complicações , Neoplasias Cerebelares/metabolismo , Contagem de Eritrócitos , Hemangiossarcoma/complicações , Hemangiossarcoma/metabolismo , Humanos , Neoplasias Renais/complicações , Neoplasias Renais/metabolismo , Neoplasias Hepáticas/complicações , Neoplasias Hepáticas/metabolismo , Síndromes Paraneoplásicas/diagnóstico , Policitemia/diagnósticoRESUMO
Among 330 patients with Hodgkin's disease, in five development of fistula between the respiratory and alimentary tract was observed; tracheoesophageal in three and bronchoesophageal in two patients. Generalization of the disease was the cause of fistula in three patients; it appeared as a result of necrosis of the neoplastic infiltration during cytostatic treatment or radiotherapy. In the fourth patient the fistula was of iatrogenic origin (radiation induced damage), and in the fifth it was the result of secondary neoplasm (bronchial anaplastic cancer).
Assuntos
Fístula Brônquica/etiologia , Fístula Esofágica/etiologia , Doença de Hodgkin/complicações , Fístula Traqueoesofágica/etiologia , Adulto , Feminino , Humanos , MasculinoRESUMO
61 patients with Hodgkin's disease, i.e., 40.9% of all HD pts hospitalized in the years 1970-1981 are more than 10 years survivors: 46 are alive and 15 died of underlying disease or its complications. The most important prognostic factor at diagnosis was clinical advancement and the form A or B of HD. Age and sex also influenced survival but to a lesser degree. Patients living in CCR were more likely to have MC histology than those with relapsing disease, who more often showed LD and LP type. Among 5 persons with second neoplasms four disclosed NS type of HD. No statistical differences in clinical prognostic factors were encountered between further alive and those who died after more than 10-yrs. Almost all patients were able to normally continue their familial and professional lives.