RESUMO
Poly(ethylene terephthalate) film was modified with argon or perfluorohexane plasma to obtain hydrophilic or hydrophobic surfaces, respectively. Various biological experiments in vitro and in vivo were chosen in order to evaluate the influence of such treatment on biocompatibility. Plasma modification does not cause toxic effects and does not influence disadvantageously the tested polyester biocompatibility. The huge changes in surface energy cause only minor changes in the biological behaviour of the samples.
Assuntos
Materiais Biocompatíveis/química , Materiais Biocompatíveis/farmacologia , Polietilenotereftalatos/química , Polietilenotereftalatos/farmacologia , Animais , Argônio , Materiais Biocompatíveis/toxicidade , Coagulação Sanguínea/efeitos dos fármacos , Bovinos , Fluorocarbonos , Hemólise/efeitos dos fármacos , Humanos , Técnicas In Vitro , Masculino , Teste de Materiais , Polietilenotereftalatos/toxicidade , Próteses e Implantes/efeitos adversos , Ratos , Ratos Wistar , Espermatozoides/efeitos dos fármacos , Propriedades de SuperfícieRESUMO
Film of poly(ethylene terephthalate) modified with plasma of pure argon and with mixture of argon and perfluorohexane. Wettability of surface, toxic influence, reaction of tissues and influence on the blood-clotting system of modified samples were tested. Plasma was modification allowed to obtain PET both with hydrophilic and hydrophobic surface. We did not observed the increase of toxicity and of the reaction of tissues in comparison with the initial film. Modification with plasma of perfluorohexane had the test influence on the blood-clotting system.