Detalhe da pesquisa
1.
Synthesis of mizoribine prodrugs and their in vivo evaluation as immunosuppressive agents.
Bioorg Med Chem Lett
; 95: 129490, 2023 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37770001
2.
Drug Discovery of Nucleos(t)ide Antiviral Agents: Dedicated to Prof. Dr. Erik De Clercq on Occasion of His 80th Birthday.
Molecules
; 26(4)2021 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33572409
3.
The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl-Acyl Carrier Protein Binding Site of FabI.
Angew Chem Int Ed Engl
; 59(26): 10549-10556, 2020 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32208550
4.
L-Aspartic and l-glutamic acid ester-based ProTides of anticancer nucleosides: Synthesis and antitumoral evaluation.
Bioorg Med Chem Lett
; 26(9): 2142-6, 2016 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27032331
5.
Bifunctional aryloxyphosphoramidate prodrugs of 2'-C-Me-uridine: synthesis and anti-HCV activity.
Org Biomol Chem
; 14(37): 8743-8757, 2016 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-27714209
6.
Synthesis and evaluation of novel ligands for the histamine H4 receptor based on a pyrrolo[2,3-d]pyrimidine scaffold.
Bioorg Med Chem Lett
; 23(1): 132-7, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23218604
7.
Synthesis and in vitro evaluation of 2-amino-4-N-piperazinyl-6-(3,4-dimethoxyphenyl)-pteridines as dual immunosuppressive and anti-inflammatory agents.
Bioorg Med Chem Lett
; 21(1): 145-9, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21131199
8.
Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity.
J Med Chem
; 62(12): 5810-5831, 2019 06 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31136173
9.
Discovery of a Potent, Orally Bioavailable PI4KIIIß Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo.
J Med Chem
; 61(15): 6705-6723, 2018 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29952567
10.
Anti-inflammatory activity of a pteridine derivative (4AZA2096) alleviates TNBS-induced colitis in mice.
J Interferon Cytokine Res
; 26(8): 575-82, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16881868
11.
Synthesis of a Nucleobase-Modified ProTide Library.
Org Lett
; 18(22): 5816-5819, 2016 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27791384
12.
Biological activity and conformational analysis of C20 and C14 epimers of CD-ring modified trans-decalin 1alpha,25-dihydroxyvitamin D analogs.
J Steroid Biochem Mol Biol
; 89-90(1-5): 61-6, 2004 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15225748
13.
A novel short convergent entry into himbacine derivatives.
Org Lett
; 4(9): 1579-82, 2002 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-11975633
14.
Discovery of dual death-associated protein related apoptosis inducing protein kinase 1 and 2 inhibitors by a scaffold hopping approach.
J Med Chem
; 57(18): 7624-43, 2014 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-25178155
15.
Synthesis and structure-activity relationship studies of 2-(1,3,4-oxadiazole-2(3H)-thione)-3-amino-5-arylthieno[2,3-b]pyridines as inhibitors of DRAK2.
ChemMedChem
; 9(11): 2587-601, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25146684
16.
A PKS/NRPS/FAS hybrid gene cluster from Serratia plymuthica RVH1 encoding the biosynthesis of three broad spectrum, zeamine-related antibiotics.
PLoS One
; 8(1): e54143, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23349809
17.
Discovery of 7-N-piperazinylthiazolo[5,4-d]pyrimidine analogues as a novel class of immunosuppressive agents with in vivo biological activity.
J Med Chem
; 54(2): 655-68, 2011 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21171614
18.
The kalimantacin/batumin biosynthesis operon encodes a self-resistance isoform of the FabI bacterial target.
Chem Biol
; 17(10): 1067-71, 2010 Oct 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-21035728
19.
Isolation and purification of a new kalimantacin/batumin-related polyketide antibiotic and elucidation of its biosynthesis gene cluster.
Chem Biol
; 17(2): 149-59, 2010 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20189105
20.
Synthesis and affinity studies of himbacine derived muscarinic receptor antagonists.
Bioorg Med Chem Lett
; 12(15): 1909-12, 2002 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-12113806