Carbon nanomaterials: A growing tool for the diagnosis and treatment of diabetes mellitus.

Diabetes mellitus is a growing disease that affects people of different ages due to deficiencies in insulin action and secretion. Diabetes causing long-term hyperglycemia damages, destroys, and fails essential organs, including kidneys, eyes, hearts, nerves, and blood vessels. The involvement of pathogenic factors makes diabetes mellitus a severe disease. The autoimmune process results in insulin deficiency by destroying the beta-cells in the pancreas. This leads to insulin resistance. As a result of defects and abnormalities in fat, carbohydrate, and protein synthesis, insulin does not work as it should on the target tissues. As diabetes mellitus becomes, more severe, long-term and effective treatment becomes necessary. A wide range of nanomaterials can be used to treat diabetes mellitus in patients. In addition to being potential imaging, diagnostic, and treatment agents for diabetes mellitus, carbon nanomaterials (CNMs) are another group of nanoparticles that exhibit potential interest. The CNMs acts as implantable nanosensor to track and detect blood glucose level in patients with diabetes. CNMS are possible drug carriers that can treat diabetes mellitus selectively, precisely, and effectively. Diabetes mellitus can be diagnosed and treated with CNMs due to their structural specificity and high drug-loading efficiency. The present review explores CNMs for their types, synthesis, and anti-diabetic properties. This review aims to provide a detailed view of the new technology that can be used to decipher the mechanism of CNMs in diabetes mellitus.

Comparative study of zinc oxide nanoparticles synthesized through biogenic and chemical route with reference to antibacterial, antibiofilm and anticancer activities.

The present focused on comparative study on synthesis of ZnO nanoparticles (ZnO NPs) using chemical method via alkaline precipitation method (ZnO(A) NPs) using NaOH and biogenic method using termite mound extract (ZnO(B) NPs). GC-MS analysis revealed that D-limonene present in termite mound extract might be responsible for the synthesis of ZnO(B) NPs. XRD patterns confirmed hexagonal crystalline structure of ZnO(A) and (B) NPs. Results of antibacterial activity illustrated that ZnO(B) NPs showed its potential against Pseudomonas aeruginosa, ESBL-1, ESBL-2 and EBSL-3. Antibiofilm studies revealed that ZnO(B) NPs exhibited optimum decline in MRSA biofilm formation than ZnO(A) NPs. In addition, ZnO(B) NPs showed potent cytotoxic effect against lung cancer cell lines A549 with IC50 of 35.16 ± 0.10 µg/mL in comparison with ZnO(A) NPs (IC50- 55.09 ± 0.30 µg/mL). Overall, the results revealed that biogenic synthesis of ZnO NPs ensures its biosafety level and enhanced biological activity when compared to chemical synthesis method.

Optimistic and possible contribution of nanomaterial on biomedical applications: A review.

Nanomaterials have many advantages over bulk materials, including enhanced surface-to-volume proportion as well as magnetic traits. It has been a steady rise in research with using nanomaterials in various biomedical fields in the past few decades. Constructing nanomaterials has emerged as a leading research primary concern in order to discover specialized biomedical applications. Since, their advantageous properties including chemical stability, non-toxicity, bio - compatibility, relatively high magnetization, and strong magnetic vulnerability, nanoparticles of iron oxide had already influenced implementations in different biomedical fields. Nanomaterials can be divided up into four nanomaterials such as metallic nanomaterials, bimetallic or alloy nanomaterials, metal oxide nanomaterials, as well as magnetic nanomaterials. Hence, the purpose of this review is to conduct such in discussion on emerging advancements in nanomaterials for biomedical, with such a special emphasis upon those options of nanomaterials including metallic nanomaterials: Au and Ag, bimetallic nanomaterials: Fe-Co and Fe-Pt, and metal oxides: TiO2 and CeO2. Securing this information gap will result in a better comprehension of the contribution of nanomaterial type and subsequent huge-scale applications in aspects of both their potential and challenges.

Remediation competence of nanoparticles amalgamated biochar (nanobiochar/nanocomposite) on pollutants: A review.

Advanced biochar blended nanoparticles substances, such as nano biochar or nanocomposites, have provided long-term solutions to a wide range of modern-day problems. Biochar blended nano-composites can be created to create better composite materials that combine the benefits of biochar and nanoparticles. Such materials have been typically improved with active functional groups, porous structure, active surface area, catalytic deterioration ability, as well as easy recovery or separation of pollutants. Such biochar-basednanocomposites have good adsorption properties for a variety of pollutants in various form of polluted medium (soil and water contamination). Catalytic nanoparticle encapsulated biochar, can perform concurrently the adsorption (by biochar) as well as catalytic degradation (nanoparticles) functions for pollutants removal from polluted sites. In this review, the advanced and practically feasible techniques involved in the biochar blended nanoparticles-based nanocomposites have been discussed with environmental applications. Furthermore, the mechanisms involved in this composite material in remediation, as well as the advantages and disadvantages of biochar blended nanoparticles-based nanocomposites, were discussed, and future directions for study in this field were suggested.

Bio-functionalized copper oxide/chitosan nanocomposite using Sida cordifolia and their efficient properties of antibacterial, anticancer activity against on breast and lung cancer cell lines.

Nanoparticles synthesis from green chemistry method is gaining a lot of attention due to their non-toxic, low cost and facile. In this study, a copper oxide nanoparticle (CuO NPs) was synthesized using Sida cordifolia aqueous leaf extract and incorporated chitosan biomolecules to potential enhancing of biological properties. The CuO NPs and chitosan (CS) embedded nanocomposite was noted as CuO-CS nanocomposite, its was physicochemical characterized by using of UV-Visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FT-IR), X-ray Diffraction (XRD) and Field emission scanning electron microscopy (FE-SEM) with Energy dispersive X-ray (EDX) analysis. Bio-functionalized CuO-CS nanocomposite was performed antibacterial efficiency against both Gram positive (Staphylococcus aureus, Bacillus subtilis) and Gram negative (Salmonella typhi, Escherichia coli) bacteria through the Mueller Hinton agar (MHA) well diffusion techniques. The highest bactericidal activity was revealed Gram positive of B. subtilis and Gram negative of S. typhi bacteria, respectively. Further, the cytotoxicity effect of biosynthesized nanocomposite was an examined against human breast cancer MDA-MB-231 and lung cancer A549 cell lines. The half maximal inhibitory concentration is showed at 2 µg/mL for MDA-MB-231and 4 µg/mL was A549 cells. Live/dead cells were detected by fluorescence microscopic observation at the IC50 concentration. In furthermore, bio-functionalized CuO-CS nanocomposite was performed photocatatlytic dye degradation against for industrial dyes of crystal violet (CV) and malachite green (MG). From the results, synergic bio-functionalized CuO-CS nanocomposite was suggested potential suitable for biomedical applications as well as industrial wastewater treatment.

Soret Effect on MHD Casson Fluid over an Accelerated Plate with the Help of Constant Proportional Caputo Fractional Derivative.

Non-Newtonian fluid flow is significant in engineering and biomedical applications such as thermal exchangers, electrical cooling mechanisms, nuclear reactor cooling, drug delivery, blood flow analysis, and tissue engineering. The Caputo operator has emerged as a prevalent tool in fractional calculus, garnering widespread recognition. This research aims to introduce a novel derivative by merging the proportional and Caputo operators, resulting in the fractional operator known as the constant proportional Caputo. In order to demonstrate this newly defined operator's dynamic qualities, it was employed in the analysis of the unsteady Casson flow model. In addition, the current work shows an analytical analysis to determine the Soret effect on the fractionalized MHD Casson fluid over an oscillating vertical plate. Fractional partial differential equations (PDEs) are used to formulate the problem along with IBCs. The introduction of appropriate nondimensional variables converts the PDEs into dimensionless form. The precise solutions to the fractional governing PDEs are then determined by the Laplace transform method. Velocity, concentration, and temperature profiles; the impacts of the Prandtl number; fractional parameter ß and γ; and Soret and Schmidt numbers are graphically depicted. The profiles of temperature, concentration, and velocity rise with rising time and fractional parameters. Interestingly, as the Casson flow parameter is higher, fluid velocity decreases closest to the plate but increases away from the plate. Tables showing the findings for the skin-friction coefficient, Sherwood, and Nusselt numbers for a range of flow-controlling parameter values are provided. Furthermore, an investigation is undertaken to compare fractionalized and ordinary velocity fields. The results suggest that the fractional model employing a constant proportional derivative exhibits a quicker decay than the model incorporating conventional Caputo and Caputo-Fabrizio operators.

A review on optimistic development of polymeric nanocomposite membrane on environmental remediation.

Current health and environmental concerns about the abundance and drawbacks of municipal wastewater as well as industrial effluent have prompted the development of novel and innovative treatment processes. A global shortage of clean water poses significant challenges to the survival of all life forms. For the removal of both biodegradable and non-biodegradable harmful wastes/pollutants from water, sophisticated wastewater treatment technologies are required. Polymer membrane technology is critical to overcoming this major challenge. Polymer matrix-based nanocomposite membranes are among the most popular in polymer membrane technology in terms of convenience. These membranes and their major components are environmentally friendly, energy efficient, cost effective, operationally versatile, and feasible. This review provides an overview of the drawbacks as well as promising developments in polymer membrane and nanocomposite membranes for environmental remediation, with a focus on wastewater treatment. Additionally, the advantages of nanocomposite membranes such as stability, antimicrobial properties, and adsorption processes have been discussed. The goal of this review was to summarize the remediation of harmful pollutants from water and wastewater/effluent using polymer matrix-based nanocomposite membrane technology, and to highlight its shortcomings and future prospects.

Nanofibrous/biopolymeric membrane a sustainable approach to remove organic micropollutants: A review.

Aquifers are severely polluted with organic and inorganic pollutants, posing a serious threat to the global ecological system's balance. While various traditional methods are available, the development of innovative methods for effluent treatment and reuse is critical. Polymers have recently been widely used in a variety of industry sectors due to their unique properties. Biopolymers are a biodegradable material that is also a viable alternative to synthetic polymers. Biopolymers are preferably obtained from cellulose and carrageenan molecules from various biological sources. While compared with conventional non-biodegradable polymeric materials, the biopolymer possesses unique characteristics such as renewability, cost-effectiveness, biodegradability, and biocompatibility. The improvements towards the biopolymeric (natural) membranes have also been thoroughly discussed. The use of nanofillers to stabilise and improve the effectiveness of biopolymeric membranes in the elimination of organic pollutants is one of the most recent developments. This was discovered that the majority of biopolymeric membranes technology consolidated on organic pollutants. More research should be directed toward against emerging organic/persistent organic pollutants (POP) and micropollutants. Furthermore, processes for regenerating and reusing utilized biopolymer-based carbon - based materials are emphasized.