Aberrant axillary breast tissue with pseudoangiomatous stromal hyperplasia in a man.

Diagnosing accessory breast tissue in a male patient is difficult when the condition is unilateral, and there is no areola or nipple. Pseudoangiomatous hyperplasia of the mammary stroma is an uncommon benign mesenchymal proliferation that may mimic low-grade angiosarcoma. We report herein an example of tumoriform pseudoangiomatous hyperplasia of the stroma arising in the accessory breast tissue of a 38-year-old man. The condition presented as a palpable tender axillary mass. Histopathologically, there were no changes of gynecomastia. Only two cases of pseudoangiomatous hyperplasia of the stroma have been previously reported in the accessory breast tissue of men showing unilateral or bilateral gynecomastia. Our case is the first report without associated gynecomastia. Radiologic imaging features are not sufficiently specific to enable a prospective diagnosis of pseudoangiomatous hyperplasia of the stroma. Microscopic examination of the lesion is indispensable in making a definitive diagnosis. Awareness of the condition can avoid difficulty in diagnosing it. Aberrant breast tissue with mass-forming pseudoangiomatous hyperplasia of the stroma, whilst rare, should be included among the benign proliferative mesenchymal lesions of the axilla. Keywords: aberrant breast tissue-accessory breast tissue-pseudoangiomatous stromal hyperplasia-gynecomastia-angiosarcoma-axilla.

The assessment of lymph nodes missed in mesenteric tissue after standard dissection of colorectal cancer specimens.

OBJECTIVE: We studied fresh mesenteric and mesorectal tissue after standard dissection of colorectal cancer specimens using a clearing method to evaluate lymph nodes (LN) that could have been missed. METHOD: After traditional dissection, 50 consecutive unfixed residual mesenteric and mesorectal tissues were entirely managed by a new clearing solution, which incorporates hydrochloric acid obtaining a really good degree of fat dissolution, facilitating the identification of missed LNs. RESULTS: By fat clearance, 498 (mean per specimen, 10) additional LNs were found, most of them (83%) varying in size from 1 to 5 mm. and 22 (4.41%) LNs revealed tumour metastases. In two rectal carcinoma specimens that had been treated by neoadjuvant chemoradiotherapy, no LNs were found by traditional dissection; after checking by the clearing method, additional LNs were harvested in both. Three patients were reclassified and upstaged. CONCLUSION: According to our findings, after standard dissection in the remaining mesentery of colorectal specimen there are missed positive LNs, which should be evaluated to avoid pathological understaging.