Pesquisa | BVS Violência e Saúde

1.

Fecal Pharmacokinetics and Gut Microbiome Effects of Oral Omadacycline Versus Vancomycin in Healthy Volunteers.

Jo, Jinhee; Hu, Chenlin; Begum, Khurshida; Wang, Weiqun; Le, Thanh M; Agyapong, Samantha; Hanson, Blake M; Ayele, Hossaena; Lancaster, Chris; Jahangir Alam, M; Gonzales-Luna, Anne J; Garey, Kevin W.

J Infect Dis ; 229(1): 273-281, 2024 Jan 12.

Artigo em Inglês | MEDLINE | ID: mdl-38051631

2.

Reduced Vancomycin Susceptibility in Clostridioides difficile is Associated with Lower Rates of Initial Cure and Sustained Clinical Response.

Eubank, Taryn A; Dureja, Chetna; Garey, Kevin W; Hurdle, Julian G; Gonzales-Luna, Anne J.

Clin Infect Dis ; 2024 Feb 21.

Artigo em Inglês | MEDLINE | ID: mdl-38382090

3.

A Randomized, Double-Blind, Phase 3 Safety and Efficacy Study of Ridinilazole Versus Vancomycin for Treatment of Clostridioides difficile Infection: Clinical Outcomes With Microbiome and Metabolome Correlates of Response.

Okhuysen, Pablo C; Ramesh, Mayur S; Louie, Thomas; Kiknadze, Nino; Torre-Cisneros, Julian; de Oliveira, Claudia Murta; Van Steenkiste, Christophe; Stychneuskaya, Alena; Garey, Kevin W; Garcia-Diaz, Julia; Li, Jianling; Duperchy, Esther; Chang, Betty Y; Sukbuntherng, Juthamas; Montoya, Jose G; Styles, Lori; Clow, Fong; James, Danelle; Dubberke, Erik R; Wilcox, Mark.

Clin Infect Dis ; 2024 Feb 02.

Artigo em Inglês | MEDLINE | ID: mdl-38305378

4.

Antibacterial activity of ibezapolstat against antimicrobial-resistant clinical strains of Clostridioides difficile.

Bassères, Eugénie; Eubank, Taryn A; Begum, Khurshida; Alam, M Jahangir; Jo, Jinhee; Le, Thanh M; Lancaster, Chris K; Gonzales-Luna, Anne J; Garey, Kevin W.

Antimicrob Agents Chemother ; 68(3): e0162123, 2024 Mar 06.

Artigo em Inglês | MEDLINE | ID: mdl-38364016

5.

Microscopy methods for Clostridioides difficile.

Hu, Chenlin; Garey, Kevin W.

Anaerobe ; 86: 102822, 2024 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38341023

6.

Review Article: Safety of Live Biotherapeutic Products Used for the Prevention of Clostridioides difficile Infection Recurrence.

Gonzales-Luna, Anne J; Carlson, Travis J; Garey, Kevin W.

Clin Infect Dis ; 77(Suppl 6): S487-S496, 2023 12 05.

Artigo em Inglês | MEDLINE | ID: mdl-38051970

7.

Validation of a Health-Related Quality of Life Questionnaire in Patients With Recurrent Clostridioides difficile Infection in ECOSPOR III, a Phase 3 Randomized Trial.

Lapin, Brittany; Garey, Kevin W; Wu, Henry; Pham, Sissi V; Huang, Shirley P; Reese, Pat Ray; Wang, Elaine; Deshpande, Abhishek.

Clin Infect Dis ; 76(3): e1195-e1201, 2023 02 08.

Artigo em Inglês | MEDLINE | ID: mdl-35789381

8.

Stool Interleukin-1ß Differentiates Clostridioides difficile Infection (CDI) From Asymptomatic Carriage and Non-CDI Diarrhea.

Villafuerte Gálvez, Javier A; Pollock, Nira R; Alonso, Carolyn D; Chen, Xinhua; Xu, Hua; Wang, Lamei; White, Nicole; Banz, Alice; Miller, Mark; Daugherty, Kaitlyn; Gonzalez-Luna, Anne J; Barrett, Caitlin; Sprague, Rebecca; Garey, Kevin W; Kelly, Ciaran P.

Clin Infect Dis ; 76(3): e1467-e1475, 2023 02 08.

Artigo em Inglês | MEDLINE | ID: mdl-35906836

9.

The Novel DNA Binding Mechanism of Ridinilazole, a Precision Clostridiodes difficile Antibiotic.

Mason, Clive S; Avis, Tim; Hu, Chenlin; Nagalingam, Nabeetha; Mudaliar, Manikhandan; Coward, Chris; Begum, Khurshida; Gajewski, Kathleen; Alam, M Jahangir; Bassères, Eugenie; Moss, Stephen; Reich, Stefanie; Duperchy, Esther; Fox, Keith R; Garey, Kevin W; Powell, David J.

Antimicrob Agents Chemother ; 67(5): e0156322, 2023 05 17.

Artigo em Inglês | MEDLINE | ID: mdl-37093023

10.

Omadacycline and Clostridioides difficile: A Systematic Review of Preclinical and Clinical Evidence.

Garey, Kevin W; Rose, Warren; Gunter, Kyle; Serio, Alisa W; Wilcox, Mark H.

Ann Pharmacother ; 57(2): 184-192, 2023 02.

Artigo em Inglês | MEDLINE | ID: mdl-35656828

11.

Nonmammalian models to study Clostridioides difficile infection; a systematic review.

Hu, Chenlin; Garey, Kevin W.

Anaerobe ; 79: 102694, 2023 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-36626950

12.

Fusobacteria behaving badly: Masquerading strains of strictly anaerobic Escherichiacoli misidentified due to the deletion of the hemB gene.

Endres, Bradley T; Basseres, Eugenie; Citron, Diane M; Tyrrell, Kerin L; Begum, Khurshida; Lancaster, Chris; Warren, Yumi A; Alam, M Jahangir; Garey, Kevin W; Goldstein, Ellie J C.

Anaerobe ; 79: 102682, 2023 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-36580991

13.

Efficacy, Safety, Pharmacokinetics, and Microbiome Changes of Ibezapolstat in Adults with Clostridioides difficile Infection: A Phase 2a Multicenter Clinical Trial.

Garey, Kevin W; McPherson, Jacob; Dinh, An Q; Hu, Chenlin; Jo, Jinhee; Wang, Weiqun; Lancaster, Chris K; Gonzales-Luna, Anne J; Loveall, Caroline; Begum, Khurshida; Jahangir Alam, M; Silverman, Michael H; Hanson, Blake M.

Clin Infect Dis ; 75(7): 1164-1170, 2022 09 30.

Artigo em Inglês | MEDLINE | ID: mdl-35134880

14.

Ultrasensitive and Quantitative Toxin Measurement Correlates With Baseline Severity, Severe Outcomes, and Recurrence Among Hospitalized Patients With Clostridioides difficile Infection.

Alonso, Carolyn D; Kelly, Ciarán P; Garey, Kevin W; Gonzales-Luna, Anne J; Williams, David; Daugherty, Kaitlyn; Cuddemi, Christine; Villafuerte-Gálvez, Javier; White, Nicole C; Chen, Xinhua; Xu, Hua; Sprague, Rebecca; Barrett, Caitlin; Miller, Mark; Foussadier, Agnès; Lantz, Aude; Banz, Alice; Pollock, Nira R.

Clin Infect Dis ; 74(12): 2142-2149, 2022 07 06.

Artigo em Inglês | MEDLINE | ID: mdl-34537841

15.

Higher In Vivo Fecal Concentrations of Clostridioides difficile Toxins A and B in Patients With North American Pulsed-Field Gel Electrophoresis Type 1/Ribotype 027 Strain Infection.

Alonso, Carolyn D; Pollock, Nira R; Garey, Kevin W; Gonzales-Luna, Anne J; Williams, David N; Daugherty, Kaitlyn; Cuddemi, Christine; Villafuerte-Gálvez, Javier; White, Nicole C; Chen, Xinhua; Xu, Hua; Sprague, Rebecca; Barrett, Caitlin; Miller, Mark; Foussadier, Agnès; Lantz, Aude; Banz, Alice; Kelly, Ciarán P.

Clin Infect Dis ; 75(11): 2019-2022, 2022 11 30.

Artigo em Inglês | MEDLINE | ID: mdl-35607815

16.

Functional and Metagenomic Evaluation of Ibezapolstat for Early Evaluation of Anti-Recurrence Effects in Clostridioides difficile Infection.

McPherson, Jacob; Hu, Chenlin; Begum, Khurshida; Wang, Weiqun; Lancaster, Chris; Gonzales-Luna, Anne J; Loveall, Caroline; Silverman, Michael H; Alam, M Jahangir; Garey, Kevin W.

Antimicrob Agents Chemother ; 66(8): e0224421, 2022 08 16.

Artigo em Inglês | MEDLINE | ID: mdl-35862742

17.

Fusobacteriumnucleatum Adheres to Clostridioides difficile via the RadD Adhesin to Enhance Biofilm Formation in Intestinal Mucus.

Engevik, Melinda A; Danhof, Heather A; Auchtung, Jennifer; Endres, Bradley T; Ruan, Wenly; Bassères, Eugénie; Engevik, Amy C; Wu, Qinglong; Nicholson, Maribeth; Luna, Ruth Ann; Garey, Kevin W; Crawford, Sue E; Estes, Mary K; Lux, Renate; Yacyshyn, Mary Beth; Yacyshyn, Bruce; Savidge, Tor; Britton, Robert A; Versalovic, James.

Gastroenterology ; 160(4): 1301-1314.e8, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33227279

18.

Development of the invasive candidiasis discharge [I Can discharge] model: a mixed methods analysis.

Jo, Jinhee; Tran, Truc T; Beyda, Nicholas D; Simmons, Debora; Hendrickson, Joshua A; Almutairi, Masaad Saeed; Alnezary, Faris S; Gonzales-Luna, Anne J; Septimus, Edward J; Garey, Kevin W.

Eur J Clin Microbiol Infect Dis ; 41(10): 1207-1213, 2022 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-36002777

19.

Fulminant Clostridioides difficile Infection: A Review of Treatment Options for a Life-Threatening Infection.

Carlson, Travis J; Gonzales-Luna, Anne J; Garey, Kevin W.

Semin Respir Crit Care Med ; 43(1): 28-38, 2022 02.

Artigo em Inglês | MEDLINE | ID: mdl-35172356

20.

Multi-country surveillance of Clostridioides difficile demonstrates high prevalence of spores in non-healthcare environmental settings.

Jo, Jinhee; Gonzales-Luna, Anne J; Lancaster, Chris K; McPherson, Jacob K; Begum, Khurshida; Jahangir Alam, M; Garey, Kevin W.

Anaerobe ; 75: 102543, 2022 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-35227896

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