1.
J Org Chem
; 86(13): 9163-9180, 2021 Jul 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34153182
RESUMO
The deprotection of chiral 1,2-bis(tosylamides) to their corresponding 1,2-diamines is mostly unsuccessful under standard conditions. In a new methodology, the use of Mg/MeOH with sufficient steric additions allows the facile synthesis of 1,2-diamines in 78-98% yields. These results are rationalized using density functional theory and the examination of inner and outer-sphere reduction mechanisms.