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1.
Am J Phys Anthropol ; 167(3): 656-671, 2018 11.
Artigo em Inglês | MEDLINE | ID: mdl-30192370

RESUMO

OBJECTIVES: We investigated the genetic history of southern African populations with a special focus on their paternal history. We reexamined previous claims that the Y-chromosome haplogroup E1b1b (E-M293) was brought to southern Africa by pastoralists from eastern Africa, and investigated patterns of sex-biased gene flow in southern Africa. MATERIALS AND METHODS: We analyzed previously published complete mtDNA genome sequences and ∼900 kb of NRY sequences from 23 populations from Namibia, Botswana, and Zambia, as well as haplogroup frequencies from a large sample of southern African populations and 23 newly genotyped Y-linked STR loci for samples assigned to haplogroup E1b1b. RESULTS: Our results support an eastern African origin for Y-chromosome haplogroup E1b1b (E-M293); however, its current distribution in southern Africa is not strongly associated with pastoralism, suggesting more complex demographic events and/or changes in subsistence practices in this region. The Bantu expansion in southern Africa had a notable genetic impact and was probably a rapid, male-dominated expansion. Our finding of a significant increase in the intensity of the sex-biased gene flow from north to south may reflect changes in the social dynamics between Khoisan and Bantu groups over time. CONCLUSIONS: Our study shows that the population history of southern Africa has been complex, with different immigrating groups mixing to different degrees with the autochthonous populations. The Bantu expansion led to heavily sex-biased admixture as a result of interactions between Khoisan females and Bantu males, with a geographic gradient which may reflect changes in the social dynamics between Khoisan and Bantu groups over time.


Assuntos
População Negra/genética , Cromossomos Humanos Y/genética , DNA Mitocondrial/genética , Fluxo Gênico/genética , África Austral , Antropologia Física , Feminino , Genética Populacional , Haplótipos/genética , Migração Humana , Humanos , Masculino
2.
Am J Phys Anthropol ; 153(3): 435-48, 2014 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-24323467

RESUMO

The Khoisan populations of southern Africa are known to harbor some of the deepest-rooting lineages of human mtDNA; however, their relationships are as yet poorly understood. Here, we report the results of analyses of complete mtDNA genome sequences from nearly 700 individuals representing 26 populations of southern Africa who speak diverse Khoisan and Bantu languages. Our data reveal a multilayered history of the indigenous populations of southern Africa, who are likely to be the result of admixture of different genetic substrates, such as resident forager populations and pre-Bantu pastoralists from East Africa. We find high levels of genetic differentiation of the Khoisan populations, which can be explained by the effect of drift together with a partial uxorilocal/multilocal residence pattern. Furthermore, there is evidence of extensive contact, not only between geographically proximate groups, but also across wider areas. The results of this contact, which may have played a role in the diffusion of common cultural and linguistic features, are especially evident in the Khoisan populations of the central Kalahari.


Assuntos
População Negra/genética , DNA Mitocondrial/genética , Genética Populacional , Antropologia Física , Botsuana , Análise por Conglomerados , Bases de Dados Genéticas , Feminino , Deriva Genética , Haplótipos/genética , Humanos , Masculino , Namíbia
3.
Nat Commun ; 3: 1143, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-23072811

RESUMO

Southern and eastern African populations that speak non-Bantu languages with click consonants are known to harbour some of the most ancient genetic lineages in humans, but their relationships are poorly understood. Here, we report data from 23 populations analysed at over half a million single-nucleotide polymorphisms, using a genome-wide array designed for studying human history. The southern African Khoisan fall into two genetic groups, loosely corresponding to the northwestern and southeastern Kalahari, which we show separated within the last 30,000 years. We find that all individuals derive at least a few percent of their genomes from admixture with non-Khoisan populations that began ∼1,200 years ago. In addition, the East African Hadza and Sandawe derive a fraction of their ancestry from admixture with a population related to the Khoisan, supporting the hypothesis of an ancient link between southern and eastern Africa.


Assuntos
Genética Populacional/história , África Austral , Análise por Conglomerados , Bases de Dados Genéticas , Etnicidade/genética , Pool Gênico , História Antiga , Humanos , Desequilíbrio de Ligação/genética , Modelos Genéticos , Dinâmica Populacional
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