Detalhe da pesquisa
1.
Discovery of positive allosteric modulators and silent allosteric modulators of the µ-opioid receptor.
Proc Natl Acad Sci U S A
; 110(26): 10830-5, 2013 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23754417
2.
Macrocyclic prolinyl acyl guanidines as inhibitors of ß-secretase (BACE).
Bioorg Med Chem Lett
; 25(22): 5040-7, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26497283
3.
Ligand-Based Discovery of a New Scaffold for Allosteric Modulation of the µ-Opioid Receptor.
J Chem Inf Model
; 55(9): 1836-43, 2015 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-26347990
4.
Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers.
Proc Natl Acad Sci U S A
; 108(37): 15366-71, 2011 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21896751
5.
Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315.
Bioorg Med Chem Lett
; 23(12): 3654-61, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23642479
6.
Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively.
bioRxiv
; 2023 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36711980
7.
A novel small molecule inhibitor of hepatitis C virus entry.
PLoS Pathog
; 6(9): e1001086, 2010 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-20838466
8.
Rapid Compound Integrity Assessment for High-Throughput Screening Hit Triaging.
SLAS Discov
; 26(2): 242-247, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-32400264
9.
Solid phase synthesis of novel pyrrolidinedione analogs as potent HIV-1 integrase inhibitors.
J Comb Chem
; 12(1): 84-90, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-19902958
10.
Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors.
J Med Chem
; 63(5): 2620-2637, 2020 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32081010
11.
Solid-phase synthesis of a library based on biphenyl-containing trypsin-like serine protease inhibitors.
Bioorg Med Chem Lett
; 19(22): 6477-80, 2009 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19804972
12.
Identification and biochemical analyses of selective CB2 agonists.
Eur J Pharmacol
; 854: 1-8, 2019 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30951717
13.
Discovery and optimization of (R)-prolinol-derived agonists of the Growth Hormone Secretagogue receptor (GHSR).
Bioorg Med Chem Lett
; 18(18): 5083-6, 2008 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18722770
14.
Discovery of Selective Cannabinoid CB2 Receptor Agonists by High-Throughput Screening.
SLAS Discov
; 23(4): 375-383, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29257918
15.
Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor.
J Med Chem
; 58(10): 4220-9, 2015 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25901762
16.
Influenza nucleoprotein: promising target for antiviral chemotherapy.
Antivir Chem Chemother
; 23(3): 77-91, 2012 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22837443
17.
Solid phase synthesis of 1,5-diarylpyrazole-4-carboxamides: discovery of antagonists of the CB-1 receptor.
ACS Comb Sci
; 14(3): 197-204, 2012 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22340081
18.
High-throughput screening and rapid inhibitor triage using an infectious chimeric Hepatitis C virus.
PLoS One
; 7(8): e42609, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22880053
19.
Acyl guanidine inhibitors of ß-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis.
J Med Chem
; 55(21): 9208-23, 2012 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23030502
20.
A high-throughput screen for receptor protein tyrosine phosphatase-gamma selective inhibitors.
J Biomol Screen
; 16(5): 476-85, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21406618