Detalhe da pesquisa
1.
Structural insight into allosteric modulation of protease-activated receptor 2.
Nature
; 545(7652): 112-115, 2017 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28445455
2.
Biosensor-Enabled Deconvolution of the Avidity-Induced Affinity Enhancement for the SARS-CoV-2 Spike Protein and ACE2 Interaction.
Anal Chem
; 94(2): 1187-1194, 2022 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34964599
3.
Fragment-assisted hit investigation involving integrated HTS and fragment screening: Application to the identification of phosphodiesterase 10A (PDE10A) inhibitors.
Bioorg Med Chem Lett
; 26(1): 197-202, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26597534
4.
Gremlin1 preferentially binds to bone morphogenetic protein-2 (BMP-2) and BMP-4 over BMP-7.
Biochem J
; 466(1): 55-68, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25378054
5.
Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily.
Proc Natl Acad Sci U S A
; 110(10): 3806-11, 2013 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23431194
6.
Drug discovery at the single molecule level: inhibition-in-solution assay of membrane-reconstituted ß-secretase using single-molecule imaging.
Anal Chem
; 87(8): 4100-3, 2015 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25855499
7.
Preserved transmembrane protein mobility in polymer-supported lipid bilayers derived from cell membranes.
Anal Chem
; 87(18): 9194-203, 2015 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26268463
8.
Equilibrium-fluctuation analysis for interaction studies between natural ligands and single G protein-coupled receptors in native lipid vesicles.
Langmuir
; 31(39): 10774-80, 2015 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26347379
9.
Characterization of a small molecule inhibitor of plasminogen activator inhibitor type 1 that accelerates the transition into the latent conformation.
J Biol Chem
; 288(2): 873-85, 2013 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23155046
10.
Robust prediction of relative binding energies for protein-protein complex mutations using free energy perturbation calculations.
J Mol Biol
; : 168640, 2024 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38844044
11.
Robust prediction of relative binding energies for protein-protein complex mutations using free energy perturbation calculations.
bioRxiv
; 2024 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38712280
12.
Identification of structural-kinetic and structural-thermodynamic relationships for thrombin inhibitors.
Biochemistry
; 52(4): 613-26, 2013 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-23290007
13.
An enhanced biophysical screening strategy to investigate the affinity of ASOs for their target RNA.
RSC Chem Biol
; 4(12): 1123-1130, 2023 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38033730
14.
Direct cell extraction of membrane proteins for structure-function analysis.
Sci Rep
; 13(1): 1420, 2023 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36697499
15.
Synthesis and structure-activity relationship of 4-(1,3-benzothiazol-2-yl)-thiophene-2-sulfonamides as cyclin-dependent kinase 5 (cdk5)/p25 inhibitors.
Bioorg Med Chem Lett
; 22(18): 5919-23, 2012 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22889803
16.
Application of optical biosensors in small-molecule screening activities.
Sensors (Basel)
; 12(4): 4311-23, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22666031
17.
Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction.
J Med Chem
; 65(4): 3473-3517, 2022 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35108001
18.
Mining Natural Products for Macrocycles to Drug Difficult Targets.
J Med Chem
; 64(2): 1054-1072, 2021 01 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33337880
19.
Regenerable Biosensors for Small-Molecule Kinetic Characterization Using SPR.
SLAS Discov
; 26(5): 730-739, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33289457
20.
Affinity-based, biophysical methods to detect and analyze ligand binding to recombinant proteins: matching high information content with high throughput.
J Struct Biol
; 172(1): 142-57, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20609391