Pesquisa | BVS Violência e Saúde

1.

Thorny ground, rocky soil: Tissue-specific mechanisms of tumor dormancy and relapse.

Lim, Andrea R; Ghajar, Cyrus M.

Semin Cancer Biol ; 78: 104-123, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-33979673

2.

Tumour exosome integrins determine organotropic metastasis.

Hoshino, Ayuko; Costa-Silva, Bruno; Shen, Tang-Long; Rodrigues, Goncalo; Hashimoto, Ayako; Tesic Mark, Milica; Molina, Henrik; Kohsaka, Shinji; Di Giannatale, Angela; Ceder, Sophia; Singh, Swarnima; Williams, Caitlin; Soplop, Nadine; Uryu, Kunihiro; Pharmer, Lindsay; King, Tari; Bojmar, Linda; Davies, Alexander E; Ararso, Yonathan; Zhang, Tuo; Zhang, Haiying; Hernandez, Jonathan; Weiss, Joshua M; Dumont-Cole, Vanessa D; Kramer, Kimberly; Wexler, Leonard H; Narendran, Aru; Schwartz, Gary K; Healey, John H; Sandstrom, Per; Labori, Knut Jørgen; Kure, Elin H; Grandgenett, Paul M; Hollingsworth, Michael A; de Sousa, Maria; Kaur, Sukhwinder; Jain, Maneesh; Mallya, Kavita; Batra, Surinder K; Jarnagin, William R; Brady, Mary S; Fodstad, Oystein; Muller, Volkmar; Pantel, Klaus; Minn, Andy J; Bissell, Mina J; Garcia, Benjamin A; Kang, Yibin; Rajasekhar, Vinagolu K; Ghajar, Cyrus M.

Nature ; 527(7578): 329-35, 2015 Nov 19.

Artigo em Inglês | MEDLINE | ID: mdl-26524530

3.

Anti-angiogenic Therapy-Mediated Endothelial Damage: A Driver of Breast Cancer Recurrence?

Pisarsky, Laura; Ghajar, Cyrus M.

Adv Exp Med Biol ; 1100: 19-45, 2018.

Artigo em Inglês | MEDLINE | ID: mdl-30411258

4.

Metastasis: Pathways of parallel progression.

Ghajar, Cyrus M; Bissell, Mina J.

Nature ; 540(7634): 528-529, 2016 Dec 22.

Artigo em Inglês | MEDLINE | ID: mdl-27974802

5.

Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin ß1.

Mori, Hidetoshi; Lo, Alvin T; Inman, Jamie L; Alcaraz, Jordi; Ghajar, Cyrus M; Mott, Joni D; Nelson, Celeste M; Chen, Connie S; Zhang, Hui; Bascom, Jamie L; Seiki, Motoharu; Bissell, Mina J.

Development ; 140(2): 343-52, 2013 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-23250208

6.

Poised epigenetic states dictate metastatic fitness.

Tomasin, Rebeka; Ghajar, Cyrus M.

Trends Cancer ; 10(4): 275-276, 2024 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38521653

7.

Immune evasion of dormant disseminated tumor cells is due to their scarcity and can be overcome by T cell immunotherapies.

Goddard, Erica T; Linde, Miles H; Srivastava, Shivani; Klug, Grant; Shabaneh, Tamer B; Iannone, Santino; Grzelak, Candice A; Marsh, Sydney; Riggio, Alessandra I; Shor, Ryann E; Linde, Ian L; Guerrero, Marissa; Veatch, Joshua R; Snyder, Annelise G; Welm, Alana L; Riddell, Stanley R; Ghajar, Cyrus M.

Cancer Cell ; 42(1): 119-134.e12, 2024 01 08.

Artigo em Inglês | MEDLINE | ID: mdl-38194912

8.

Laser scanning-based tissue autofluorescence/fluorescence imaging (LS-TAFI), a new technique for analysis of microanatomy in whole-mount tissues.

Mori, Hidetoshi; Borowsky, Alexander D; Bhat, Ramray; Ghajar, Cyrus M; Seiki, Motoharu; Bissell, Mina J.

Am J Pathol ; 180(6): 2249-56, 2012 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-22542846

9.

Elimination of 4T1 Mammary Tumor Cells by BALB/cBy UBC-GFP Transgenics following Stable Inheritance of the H-2b MHC Allele.

Grzelak, Candice A; Ghajar, Cyrus M.

Immunohorizons ; 7(1): 64-70, 2023 01 01.

Artigo em Inglês | MEDLINE | ID: mdl-36637515

10.

The PI3K/mTOR inhibitor Gedatolisib eliminates dormant breast cancer cells in organotypic culture, but fails to prevent metastasis in preclinical settings.

Shor, Ryann E; Dai, Jinxiang; Lee, Sun-Young; Pisarsky, Laura; Matei, Irina; Lucotti, Serena; Lyden, David; Bissell, Mina J; Ghajar, Cyrus M.

Mol Oncol ; 16(1): 130-147, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-34058066

11.

Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells.

Crist, Sarah B; Nemkov, Travis; Dumpit, Ruth F; Dai, Jinxiang; Tapscott, Stephen J; True, Lawrence D; Swarbrick, Alexander; Sullivan, Lucas B; Nelson, Peter S; Hansen, Kirk C; Ghajar, Cyrus M.

Nat Cell Biol ; 24(4): 538-553, 2022 04.

Artigo em Inglês | MEDLINE | ID: mdl-35411081

12.

Metastasis.

Lyden, David; Ghajar, Cyrus M; Correia, Ana Luísa; Aguirre-Ghiso, Julio A; Cai, Shang; Rescigno, Maria; Zhang, Peiyuan; Hu, Guohong; Fendt, Sarah-Maria; Boire, Adrienne; Weichselbaum, Ralph R; Katipally, Rohan R.

Cancer Cell ; 40(8): 787-791, 2022 08 08.

Artigo em Inglês | MEDLINE | ID: mdl-35944497

13.

Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain.

Dai, Jinxiang; Cimino, Patrick J; Gouin, Kenneth H; Grzelak, Candice A; Barrett, Alexander; Lim, Andrea R; Long, Annalyssa; Weaver, Stephanie; Saldin, Lindsey T; Uzamere, Aiyedun; Schulte, Vera; Clegg, Nigel; Pisarsky, Laura; Lyden, David; Bissell, Mina J; Knott, Simon; Welm, Alana L; Bielas, Jason H; Hansen, Kirk C; Winkler, Frank; Holland, Eric C; Ghajar, Cyrus M.

Nat Cancer ; 3(1): 25-42, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-35121993

14.

Defining cellular population dynamics at single-cell resolution during prostate cancer progression.

Germanos, Alexandre A; Arora, Sonali; Zheng, Ye; Goddard, Erica T; Coleman, Ilsa M; Ku, Anson T; Wilkinson, Scott; Song, Hanbing; Brady, Nicholas J; Amezquita, Robert A; Zager, Michael; Long, Annalysa; Yang, Yu Chi; Bielas, Jason H; Gottardo, Raphael; Rickman, David S; Huang, Franklin W; Ghajar, Cyrus M; Nelson, Peter S; Sowalsky, Adam G; Setty, Manu; Hsieh, Andrew C.

Elife ; 112022 12 13.

Artigo em Inglês | MEDLINE | ID: mdl-36511483

15.

Mesenchymal cells stimulate capillary morphogenesis via distinct proteolytic mechanisms.

Ghajar, Cyrus M; Kachgal, Suraj; Kniazeva, Ekaterina; Mori, Hidetoshi; Costes, Sylvain V; George, Steven C; Putnam, Andrew J.

Exp Cell Res ; 316(5): 813-25, 2010 Mar 10.

Artigo em Inglês | MEDLINE | ID: mdl-20067788

16.

When a House Is Not a Home: A Survey of Antimetastatic Niches and Potential Mechanisms of Disseminated Tumor Cell Suppression.

Crist, Sarah B; Ghajar, Cyrus M.

Annu Rev Pathol ; 16: 409-432, 2021 01 24.

Artigo em Inglês | MEDLINE | ID: mdl-33276706

17.

Quis custodiet ipsos custodies: who watches the watchmen?

Ghajar, Cyrus M; Meier, Roland; Bissell, Mina J.

Am J Pathol ; 174(6): 1996-9, 2009 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-19465642

18.

Recreating the perivascular niche ex vivo using a microfluidic approach.

Carrion, Bita; Huang, Carlos P; Ghajar, Cyrus M; Kachgal, Suraj; Kniazeva, Ekaterina; Jeon, Noo Li; Putnam, Andrew J.

Biotechnol Bioeng ; 107(6): 1020-8, 2010 Dec 15.

Artigo em Inglês | MEDLINE | ID: mdl-20672286

19.

Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy.

Carlson, Patrick; Dasgupta, Arko; Grzelak, Candice A; Kim, Jeanna; Barrett, Alexander; Coleman, Ilsa M; Shor, Ryann E; Goddard, Erica T; Dai, Jinxiang; Schweitzer, Emma M; Lim, Andrea R; Crist, Sarah B; Cheresh, David A; Nelson, Peter S; Hansen, Kirk C; Ghajar, Cyrus M.

Nat Cell Biol ; 21(2): 238-250, 2019 02.

Artigo em Inglês | MEDLINE | ID: mdl-30664790

20.

Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis.

Rodrigues, Gonçalo; Hoshino, Ayuko; Kenific, Candia M; Matei, Irina R; Steiner, Loïc; Freitas, Daniela; Kim, Han Sang; Oxley, Peter R; Scandariato, Ilana; Casanova-Salas, Irene; Dai, Jinxiang; Badwe, Chaitanya R; Gril, Brunilde; Tesic Mark, Milica; Dill, Brian D; Molina, Henrik; Zhang, Haiying; Benito-Martin, Alberto; Bojmar, Linda; Ararso, Yonathan; Offer, Katharine; LaPlant, Quincey; Buehring, Weston; Wang, Huajuan; Jiang, Xinran; Lu, Tyler M; Liu, Yuan; Sabari, Joshua K; Shin, Sandra J; Narula, Navneet; Ginter, Paula S; Rajasekhar, Vinagolu K; Healey, John H; Meylan, Etienne; Costa-Silva, Bruno; Wang, Shizhen Emily; Rafii, Shahin; Altorki, Nasser Khaled; Rudin, Charles M; Jones, David R; Steeg, Patricia S; Peinado, Héctor; Ghajar, Cyrus M; Bromberg, Jacqueline; de Sousa, Maria; Pisapia, David; Lyden, David.

Nat Cell Biol ; 21(11): 1403-1412, 2019 11.

Artigo em Inglês | MEDLINE | ID: mdl-31685984

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