Pesquisa | BVS Violência e Saúde

1.

Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses.

Behrens, Gesine; Edelmann, Stephanie L; Raj, Timsse; Kronbeck, Nina; Monecke, Thomas; Davydova, Elena; Wong, Elaine H; Kifinger, Lisa; Giesert, Florian; Kirmaier, Martin E; Hohn, Christine; de Jonge, Laura S; Pisfil, Mariano Gonzalez; Fu, Mingui; Theurich, Sebastian; Feske, Stefan; Kawakami, Naoto; Wurst, Wolfgang; Niessing, Dierk; Heissmeyer, Vigo.

Nat Immunol ; 22(12): 1563-1576, 2021 12.

Artigo em Inglês | MEDLINE | ID: mdl-34811541

2.

Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity.

Schmidt, Henrik; Raj, Timsse; O'Neill, Thomas J; Muschaweckh, Andreas; Giesert, Florian; Negraschus, Arlinda; Hoefig, Kai P; Behrens, Gesine; Esser, Lena; Baumann, Christina; Feederle, Regina; Plaza-Sirvent, Carlos; Geerlof, Arie; Gewies, Andreas; Isay, Sophie E; Ruland, Jürgen; Schmitz, Ingo; Wurst, Wolfgang; Korn, Thomas; Krappmann, Daniel; Heissmeyer, Vigo.

Proc Natl Acad Sci U S A ; 120(48): e2309205120, 2023 Nov 28.

Artigo em Inglês | MEDLINE | ID: mdl-37988467

3.

Engrailed 1 deficiency induces changes in ciliogenesis during human neuronal differentiation.

Hembach, Sina; Schmidt, Sebastian; Orschmann, Tanja; Burtscher, Ingo; Lickert, Heiko; Giesert, Florian; Weisenhorn, Daniela Vogt; Wurst, Wolfgang.

Neurobiol Dis ; 194: 106474, 2024 May.

Artigo em Inglês | MEDLINE | ID: mdl-38518837

4.

Mammalian VPS45 orchestrates trafficking through the endosomal system.

Frey, Laura; Zietara, Natalia; Lyszkiewicz, Marcin; Marquardt, Benjamin; Mizoguchi, Yoko; Linder, Monika I; Liu, Yanshan; Giesert, Florian; Wurst, Wolfgang; Dahlhoff, Maik; Schneider, Marlon R; Wolf, Eckhard; Somech, Raz; Klein, Christoph.

Blood ; 137(14): 1932-1944, 2021 04 08.

Artigo em Inglês | MEDLINE | ID: mdl-33512427

5.

Identification of ocular regulatory functions of core histone variant H3.2.

Vetrivel, Sharmilee; Truong, Dong-Jiunn Jeffery; Wurst, Wolfgang; Graw, Jochen; Giesert, Florian.

Exp Eye Res ; 226: 109346, 2023 01.

Artigo em Inglês | MEDLINE | ID: mdl-36529279

6.

Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia.

Vetrivel, Sharmilee; Tiso, Natascia; Kügler, Andrea; Irmler, Martin; Horsch, Marion; Beckers, Johannes; Hladik, Daniela; Giesert, Florian; Gailus-Durner, Valerie; Fuchs, Helmut; Sabrautzki, Sibylle; Hrabe de Angelis, Martin; Graw, Jochen.

Exp Eye Res ; 188: 107632, 2019 11.

Artigo em Inglês | MEDLINE | ID: mdl-30991053

7.

Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon.

Spieler, Derek; Kaffe, Maria; Knauf, Franziska; Bessa, José; Tena, Juan J; Giesert, Florian; Schormair, Barbara; Tilch, Erik; Lee, Heekyoung; Horsch, Marion; Czamara, Darina; Karbalai, Nazanin; von Toerne, Christine; Waldenberger, Melanie; Gieger, Christian; Lichtner, Peter; Claussnitzer, Melina; Naumann, Ronald; Müller-Myhsok, Bertram; Torres, Miguel; Garrett, Lillian; Rozman, Jan; Klingenspor, Martin; Gailus-Durner, Valérie; Fuchs, Helmut; Hrabe de Angelis, Martin; Beckers, Johannes; Hölter, Sabine M; Meitinger, Thomas; Hauck, Stefanie M; Laumen, Helmut; Wurst, Wolfgang; Casares, Fernando; Gómez-Skarmeta, Jose Luis; Winkelmann, Juliane.

Genome Res ; 24(4): 592-603, 2014 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-24642863

8.

c-Abl phosphorylation primes PARIS for neurodegeneration.

Giesert, Florian.

Brain ; 144(12): 3555-3557, 2021 12 31.

Artigo em Inglês | MEDLINE | ID: mdl-34788407

9.

Diversity matters - heterogeneity of dopaminergic neurons in the ventral mesencephalon and its relation to Parkinson's Disease.

Vogt Weisenhorn, Daniela Maria; Giesert, Florian; Wurst, Wolfgang.

J Neurochem ; 139 Suppl 1: 8-26, 2016 10.

Artigo em Inglês | MEDLINE | ID: mdl-27206718

10.

A cell surface biotinylation assay to reveal membrane-associated neuronal cues: Negr1 regulates dendritic arborization.

Pischedda, Francesca; Szczurkowska, Joanna; Cirnaru, Maria Daniela; Giesert, Florian; Vezzoli, Elena; Ueffing, Marius; Sala, Carlo; Francolini, Maura; Hauck, Stefanie M; Cancedda, Laura; Piccoli, Giovanni.

Mol Cell Proteomics ; 13(3): 733-48, 2014 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-24382801

11.

LRRK2 guides the actin cytoskeleton at growth cones together with ARHGEF7 and Tropomyosin 4.

Häbig, Karina; Gellhaar, Sandra; Heim, Birgit; Djuric, Verena; Giesert, Florian; Wurst, Wolfgang; Walter, Carolin; Hentrich, Thomas; Riess, Olaf; Bonin, Michael.

Biochim Biophys Acta ; 1832(12): 2352-67, 2013 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-24075941

12.

The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression.

Xu, Meng; Ito-Kureha, Taku; Kang, Hyun-Seo; Chernev, Aleksandar; Raj, Timsse; Hoefig, Kai P; Hohn, Christine; Giesert, Florian; Wang, Yinhu; Pan, Wenliang; Zietara, Natalia; Straub, Tobias; Feederle, Regina; Daniel, Carolin; Adler, Barbara; König, Julian; Feske, Stefan; Tsokos, George C; Wurst, Wolfgang; Urlaub, Henning; Sattler, Michael; Kisielow, Jan; Wulczyn, F Gregory; Lyszkiewicz, Marcin; Heissmeyer, Vigo.

Nat Commun ; 15(1): 2194, 2024 Mar 11.

Artigo em Inglês | MEDLINE | ID: mdl-38467629

13.

A brain-enriched circular RNA controls excitatory neurotransmission and restricts sensitivity to aversive stimuli.

Giusti, Sebastian A; Pino, Natalia S; Pannunzio, Camila; Ogando, Mora B; Armando, Natalia G; Garrett, Lillian; Zimprich, Annemarie; Becker, Lore; Gimeno, Maria L; Lukin, Jeronimo; Merino, Florencia L; Pardi, M Belen; Pedroncini, Olivia; Di Mauro, Giuliana C; Durner, Valerie Gailus; Fuchs, Helmut; de Angelis, Martin Hrabe; Patop, Ines L; Turck, Christoph W; Deussing, Jan M; Vogt Weisenhorn, Daniela M; Jahn, Olaf; Kadener, Sebastian; Hölter, Sabine M; Brose, Nils; Giesert, Florian; Wurst, Wolfgang; Marin-Burgin, Antonia; Refojo, Damian.

Sci Adv ; 10(21): eadj8769, 2024 May 24.

Artigo em Inglês | MEDLINE | ID: mdl-38787942

14.

A reversible state of hypometabolism in a human cellular model of sporadic Parkinson's disease.

Schmidt, Sebastian; Stautner, Constantin; Vu, Duc Tung; Heinz, Alexander; Regensburger, Martin; Karayel, Ozge; Trümbach, Dietrich; Artati, Anna; Kaltenhäuser, Sabine; Nassef, Mohamed Zakaria; Hembach, Sina; Steinert, Letyfee; Winner, Beate; Jürgen, Winkler; Jastroch, Martin; Luecken, Malte D; Theis, Fabian J; Westmeyer, Gil Gregor; Adamski, Jerzy; Mann, Matthias; Hiller, Karsten; Giesert, Florian; Vogt Weisenhorn, Daniela M; Wurst, Wolfgang.

Nat Commun ; 14(1): 7674, 2023 Nov 23.

Artigo em Inglês | MEDLINE | ID: mdl-37996418

15.

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool.

Piccoli, Giovanni; Condliffe, Steven B; Bauer, Matthias; Giesert, Florian; Boldt, Karsten; De Astis, Silvia; Meixner, Andrea; Sarioglu, Hakan; Vogt-Weisenhorn, Daniela M; Wurst, Wolfgang; Gloeckner, Christian Johannes; Matteoli, Michela; Sala, Carlo; Ueffing, Marius.

J Neurosci ; 31(6): 2225-37, 2011 Feb 09.

Artigo em Inglês | MEDLINE | ID: mdl-21307259

16.

Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein.

Dening, Yanina; Straßl, Theresa; Ruf, Viktoria; Dirscherl, Petra; Chovsepian, Alexandra; Stievenard, Alicia; Khairnar, Amit; Schmidt, Felix; Giesert, Florian; Herms, Jochen; Levin, Johannes; Dieterich, Marianne; Falkai, Peter; Weisenhorn, Daniela Vogt; Wurst, Wolfgang; Giese, Armin; Pan-Montojo, Francisco.

Sci Rep ; 12(1): 21951, 2022 12 19.

Artigo em Inglês | MEDLINE | ID: mdl-36535974

17.

Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease.

Schmidt, Sebastian; Luecken, Malte D; Trümbach, Dietrich; Hembach, Sina; Niedermeier, Kristina M; Wenck, Nicole; Pflügler, Klaus; Stautner, Constantin; Böttcher, Anika; Lickert, Heiko; Ramirez-Suastegui, Ciro; Ahmad, Ruhel; Ziller, Michael J; Fitzgerald, Julia C; Ruf, Viktoria; van de Berg, Wilma D J; Jonker, Allert J; Gasser, Thomas; Winner, Beate; Winkler, Jürgen; Vogt Weisenhorn, Daniela M; Giesert, Florian; Theis, Fabian J; Wurst, Wolfgang.

Nat Commun ; 13(1): 4819, 2022 08 16.

Artigo em Inglês | MEDLINE | ID: mdl-35974013

18.

Parkinson's disease motor symptoms rescue by CRISPRa-reprogramming astrocytes into GABAergic neurons.

Giehrl-Schwab, Jessica; Giesert, Florian; Rauser, Benedict; Lao, Chu Lan; Hembach, Sina; Lefort, Sandrine; Ibarra, Ignacio L; Koupourtidou, Christina; Luecken, Malte Daniel; Truong, Dong-Jiunn Jeffery; Fischer-Sternjak, Judith; Masserdotti, Giacomo; Prakash, Nilima; Ninkovic, Jovica; Hölter, Sabine M; Vogt Weisenhorn, Daniela M; Theis, Fabian J; Götz, Magdalena; Wurst, Wolfgang.

EMBO Mol Med ; 14(5): e14797, 2022 05 09.

Artigo em Inglês | MEDLINE | ID: mdl-35373464

19.

CRISPR-Mediated Induction of Neuron-Enriched Mitochondrial Proteins Boosts Direct Glia-to-Neuron Conversion.

Russo, Gianluca L; Sonsalla, Giovanna; Natarajan, Poornemaa; Breunig, Christopher T; Bulli, Giorgia; Merl-Pham, Juliane; Schmitt, Sabine; Giehrl-Schwab, Jessica; Giesert, Florian; Jastroch, Martin; Zischka, Hans; Wurst, Wolfgang; Stricker, Stefan H; Hauck, Stefanie M; Masserdotti, Giacomo; Götz, Magdalena.

Cell Stem Cell ; 28(3): 524-534.e7, 2021 03 04.

Artigo em Inglês | MEDLINE | ID: mdl-33202244

20.

Rescue of STAT3 Function in Hyper-IgE Syndrome Using Adenine Base Editing.

Eberherr, Andreas C; Maaske, Andre; Wolf, Christine; Giesert, Florian; Berutti, Riccardo; Rusha, Ejona; Pertek, Anna; Kastlmeier, Miriam T; Voss, Carola; Plummer, Michelle; Sayed, Amina; Graf, Elisabeth; Effner, Renate; Volz, Thomas; Drukker, Micha; Strom, Tim M; Meitinger, Thomas; Stoeger, Tobias; Buyx, Alena M; Hagl, Beate; Renner, Ellen D.

CRISPR J ; 4(2): 178-190, 2021 04.

Artigo em Inglês | MEDLINE | ID: mdl-33876960

BVS Violência e Saúde

Informação e Conhecimento para a Saúde

Configurar filtros

Sua seleção (0)

Formato de exportação:

Exportar: