Detalhe da pesquisa
1.
Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1).
Bioorg Med Chem Lett
; 26(10): 2470-2474, 2016 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27055941
2.
Engineering of a novel anti-CD40L domain antibody for treatment of autoimmune diseases.
J Immunol
; 192(9): 4083-92, 2014 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24670803
3.
Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors.
Bioorg Med Chem Lett
; 21(15): 4633-7, 2011 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21705217
4.
Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis.
Bioorg Med Chem Lett
; 21(1): 383-6, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21087862
5.
Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2.
J Med Chem
; 64(1): 677-694, 2021 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33370104
6.
5-amino-pyrazoles as potent and selective p38α inhibitors.
Bioorg Med Chem Lett
; 20(23): 6886-9, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21035336
7.
Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK.
ACS Med Chem Lett
; 11(11): 2195-2203, 2020 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33214829
8.
Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis.
J Pharmacol Exp Ther
; 331(2): 349-60, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19652024
9.
Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IkappaB kinase.
Bioorg Med Chem Lett
; 19(10): 2646-9, 2009 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19376699
10.
Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2).
J Med Chem
; 62(20): 8953-8972, 2019 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31314518
11.
Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.
J Med Chem
; 62(20): 8973-8995, 2019 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31318208
12.
Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis.
ACS Med Chem Lett
; 10(3): 306-311, 2019 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30891131
13.
Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors.
ACS Med Chem Lett
; 10(3): 383-388, 2019 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30891145
14.
Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain.
Sci Transl Med
; 11(502)2019 07 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31341059
15.
Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK).
J Med Chem
; 62(7): 3228-3250, 2019 04 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30893553
16.
Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha mitogen-activated protein kinase inhibitors.
J Med Chem
; 51(1): 4-16, 2008 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18072718
17.
Pyrazolo-pyrimidines: a novel heterocyclic scaffold for potent and selective p38 alpha inhibitors.
Bioorg Med Chem Lett
; 18(8): 2652-7, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18359226
18.
Synthesis and SAR of new pyrrolo[2,1-f][1,2,4]triazines as potent p38 alpha MAP kinase inhibitors.
Bioorg Med Chem Lett
; 18(8): 2739-44, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18364256
19.
The discovery of (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994)-A potent and efficacious p38alpha MAP kinase inhibitor.
Bioorg Med Chem Lett
; 18(6): 1762-7, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18313298
20.
A selective small molecule agonist of the melanocortin-1 receptor inhibits lipopolysaccharide-induced cytokine accumulation and leukocyte infiltration in mice.
J Leukoc Biol
; 80(4): 897-904, 2006 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16888084