Impaired visual processing in patients with insomnia disorder revealed by a dissociation in visual search.

Insomnia disorder is associated with both subjective and objective daytime impairments. In particular, cognitive impairments are frequently reported. However, little is known about the effects of this pathology on perceptual processes. In this study we aim at evaluating the effect of insomnia disorder on visual processing by employing a visual search paradigm. Twenty-three patients with insomnia disorder and 20 healthy age- and sex-matched control subjects participated in the study. After a polysomnographic recording night patients performed a visual search task in which they had to respond to the presence/absence of a target (letter T) embedded into a set of distractors (letters Os, Xs or Ls). Target's salience and distractors' numerosity were manipulated, while accuracy and reaction times were recorded as dependent variables. The results mainly confirmed the typical effects of a visual search task. An overall delay in performing the task was observed for patients with insomnia disorder. However, distinguishing the reaction times to stimuli containing the target from reaction times to stimuli in which the target was absent, the clinical group differed from controls solely in the condition of target absent. The performance (reaction times) of the subjects correlated with the age in the control group, whereas no correlation between reaction times and age, disease duration and quality of sleep was found in patients with insomnia disorder. These results experimentally demonstrate the presence of a daytime impairment in patients with insomnia disorder revealed by a dissociation in visual search, and are discussed in the light of the hyperarousal concept of insomnia.

The DCDC2 intron 2 deletion impairs illusory motion perception unveiling the selective role of magnocellular-dorsal stream in reading (dis)ability.

Developmental dyslexia (DD) is a heritable neurodevelopmental reading disorder that could arise from auditory, visual, and cross-modal integration deficits. A deletion in intron 2 of the DCDC2 gene (hereafter DCDC2d) increases the risk for DD and related phenotypes. In this study, first we report that illusory visual motion perception-specifically processed by the magnocellular-dorsal (M-D) stream-is impaired in children with DD compared with age-matched and reading-level controls. Second, we test for the specificity of the DCDC2d effects on the M-D stream. Children with DD and DCDC2d need significantly more contrast to process illusory motion relative to their counterpart without DCDC2d and to age-matched and reading-level controls. Irrespective of the genetic variant, children with DD perform normally in the parvocellular-ventral task. Finally, we find that DCDC2d is associated with the illusory motion perception also in adult normal readers, showing that the M-D deficit is a potential neurobiological risk factor of DD rather than a simple effect of reading disorder. Our findings demonstrate, for the first time, that a specific neurocognitive dysfunction tapping the M-D stream is linked with a well-defined genetic susceptibility.

The effects of Transcranial Direct Current Stimulation (tDCS) on Idiopathic Hypersomnia: a pilot study.

Idiopathic Hypersomnia (IH) is a rare sleep disorder characterised by excessive daytime sleepiness (EDS) that leads to invalidating daytime consequences. Till now the treatment of IH has mirrored that of sleepiness in narcolepsy, and it is mainly focused on symptoms' management. We employed an anodal transcranic Direct Current Stimulation (tDCS) treatment in order to induce a shift toward arousal in IH patients' cortex during the day. Every patients underwent a 4 weeks treatment (3 stimulations per week, for a total of 12 stimulations over a period of 28 days) with an assessment at the baseline and after treatment aimed to the evaluation of subjective daytime sleepiness, neurocognitive functions, and attentional domain tested by means of the Attentional Network Task (ANT). The dependent variables of the ANT are accuracy and reaction times, which represent the objective outcome of our study. A significant effect of tDCS' treatment in reducing EDS was found. Besides the amelioration in subjective EDS,  an objective improvement in RTs in all conditions of the ANT, in particular in the more difficult component, was observed. Our results indicate that tDCS may foster the management of EDS in IH, improving also the attentional domain.

Restless legs syndrome/Willis Ekbom disease: new diagnostic criteria according to different nosology.

Restless Legs Syndrome/Willis Ekbom Disease (RLS/WED) is a common neurological disorder characterized by uncomfortable and unpleasant sensations in the legs, with an urge to move. The symptoms typically begin or worsen during periods of rest, in particular during the evening and at night, while the activity may typically relieve them. The majority of patients complains of poor sleep. Recent studies reported the prevalence is ranging from 5 to 10%. RLS/WED can be divided into primary (patients without associated conditions that may explain the symptoms) and secondary forms (mostly iron deficiency). RLS/WED is typically a chronic condition. The clinical course varies according to the age of onset. A great load of accumulating research and clinical data have led to an extended consensus for a need to enhance the diagnostic criteria. The aim of this paper is to provide a critical comparison among different diagnostic criteria, taking into account respectively the International Classification of Sleep Disorders (ICSD), the International RLS Study Group (IRLSSG) and the Diagnostic and Statistical Manual of Mental Disorders (DSM). There are several remarkable distinctions between the IRLSSG revised criteria, ICSD-3 and DSM-V. Contrary to the DSM-V criteria, ICSD-3 diagnostic criteria are more aligned to the IRLSSG ones. In fact, the five essential criteria of the IRLSSG are also required for the diagnosis of RLS/WED according to ICSD-3. The new IRLSSG criteria provide a more rigorous approach to case ascertainment and a better characterization of patients by specifying clinical significance and course. Future ascertainment of correct diagnosis should include documentation that all five diagnostic criteria are considered.

Deeper attentional masking by lateral objects in children with autism.

Autism spectrum disorder (ASD) is often associated with a detail-oriented perception and overselective attention in visual tasks, such as visual search and crowding. These results were obtained manipulating exclusively the spatial properties of the stimuli: few is known about the spatio-temporal dynamics of visual processing in ASD. In this study we employed an attentional masking (AM) paradigm comparing children with ASD and IQ-matched typically developing (TD) controls. The AM effect refers to an impaired identification of a target followed by a competitive masking object at different proximities in space and time. We found that ASD and TD groups did not differ in the AM effect provoked by the competitive object displayed in the same position of the target. In contrast, children with ASD showed a deeper and prolonged interference than the TD group when the masking object was displayed in the lateral position. These psychophysical results suggest that the inefficient attentional selection in ASD depends on the spatio-temporal interaction between competitive visual objects. These evidence are discussed in the light of the ASD altered neural connectivity hypothesis and the reentrant theory of perception.

Roberto Ardigò as a forerunner of George M. Stratton's experiments on inverted vision.

After Johannes Kepler's supposition of inverted and reversed retinal images and Christoph Scheiner's anatomical demonstration of such an inversion, the question arose whether this inversion is necessary and how it is possible to see an upright world based on an inverted image. The answer to this question is commonly attributed to the American psychologist George M. Stratton, who produced, in 1896, upright retinal images by means of lenses and showed that after a phase of inverted perception, upright vision is restored. However, prior to 1886, the Italian philosopher Roberto Ardigò had already performed optical experiments with a prism, obtaining a similar result. The intend of his optical investigation was essentially psychological, in opposition to contemporary physiological approaches. He accepted Hermann von Helmholtz's basic assumptions, but interpreted the results of his experiments in the framework of a more detailed theory of perception. The present article aims to analyze Ardigò's experiments and compare them with Stratton's in order to give them the place they deserve in the history of experimental psychology. (PsycINFO Database Record (c) 2020 APA, all rights reserved).

The risk of neurodegeneration in REM sleep behavior disorder: A systematic review and meta-analysis of longitudinal studies.

Several studies report an association between REM Sleep Behavior Disorder (RBD) and neurodegenerative diseases, in particular synucleinopathies. Interestingly, the onset of RBD precedes the development of neurodegeneration by several years. This review and meta-analysis aims to establish the rate of conversion of RBD into neurodegenerative diseases. Longitudinal studies were searched from the PubMed, Web of Science, and SCOPUS databases. Using random-effect modeling, we performed a meta-analysis on the rate of RBD conversions into neurodegeneration. Furthermore, we fitted a Kaplan-Meier analysis and compared the differences between survival curves of different diseases with log-rank tests. The risk for developing neurodegenerative diseases was 33.5% at five years follow-up, 82.4% at 10.5 years and 96.6% at 14 years. The average conversion rate was 31.95% after a mean duration of follow-up of 4.75 ± 2.43 years. The majority of RBD patients converted to Parkinson's Disease (43%), followed by Dementia with Lewy Bodies (25%). The estimated risk for RBD patients to develop a neurodegenerative disease over a long-term follow-up is more than 90%. Future studies should include control group for the evaluation of REM sleep without atonia as marker for neurodegeneration also in non-clinical population and target RBD as precursor of neurodegeneration to develop protective trials.

A single "stopwatch" for duration estimation, a single "ruler" for size.

Although observers can discriminate visual targets with long exposures from otherwise-identical targets with shorter exposures, temporally overlapping distracters with an intermediate exposure can produce a striking degradation in performance. This new finding suggests that observers can only estimate one duration at a time. Discrimination on the basis of size, rather than duration, did not degrade as rapidly with the number of distracters but was still worse than predicted by unlimited-capacity models. The critical difference between estimates of temporal length and estimates of spatial length seems to be that the former can only be made at the end of an exposure, while the latter can be made at any time during an exposure. When sizes varied throughout the trial and decisions were based on terminal sizes, the set-size effect was as large as that obtained for duration discrimination. We conclude that when textural filters are not available for segregating a target from distracters, efficient estimates of size or duration require the serial examination of individual display items.

Repetitive thought is associated with both subjectively and objectively recorded polysomnographic indices of disrupted sleep in insomnia disorder.

BACKGROUND: Repetitive thought is a hallmark of several psychopathological conditions and in particular a perpetuating and maintaining factor in Insomnia Disorder. Accordingly, one of the primary complaints reported by Insomnia patients is the inability to shut-off or control thoughts. Worry and rumination are the two best-known styles of repetitive thought leading to sleep disturbances. The aim of this study was to investigate the relationship of these two cognitive processes on nocturnal sleep indices objectively recorded by polysomnography. METHODS: 27 Insomnia patients and 20 healthy controls matched for sex and age were recruited and completed a comprehensive assessment aimed to evaluate sleep quality, excessive daytime sleepiness, insomnia severity, worry, rumination, depressive and anxious symptomatology, and the ability to produce reasonable cognitive estimates. Sleep diaries indices and polysomnographic recordings were evaluated. RESULTS: Insomnia patients showed increased levels of worry and rumination in comparison to controls. Our polysomnographic study revealed that these two different types of repetitive thoughts were significantly associated with objective sleep variables. In particular, heightened worry levels were related to an augmented wake after sleep onset and diminished total sleep time, sleep efficiency and percentage of REM sleep, whereas rumination was associated with an increase of sleep latency and a decrement of sleep efficiency. However, after controlling for anxiety and depressive symptoms only worry maintained a significant relationship with polysomnographic variables. Remarkably, repetitive thoughts did not correlate with microstructural REM sleep features and quantitative EEG analysis. CONCLUSION: Our study indicates the existence of a significant relationship between daytime levels of repetitive thought and sleep, thus corroborating the hypothesis of an interplay between cognitive and nocturnal electrophysiological activity in insomniacs.

Region- and edge-based configurational effects in texture segmentation.

We have found a new configurational effect in texture segmentation. In addition to collinear facilitation at the edge, this effect results from contextual modulation within the texture-region, i.e. from texels not abutting the segmented edge. The largest facilitation was found when two conditions were fulfilled: (i) elements along the edge were parallel to the edge and collinear, (ii) elements in the texture-region were also collinear but non-parallel to the edge. We show that this facilitation occurs when there are groups of different orientation from the edge in the texture-region. We suggest two possible underlying mechanisms: either a region-based process that links collinear iso-oriented elements and locates the edge when the orientation changes, or else second-order filters tuned to orientation differences rather than orientation per se.

Evidence of perceptive impairment in OSA patients investigated by means of a visual search task.

Obstructive Sleep Apnoea (OSA) is a common sleep disorder characterized by episodes of complete or partial obstruction of respiratory airways during sleep that leads to hypoxaemia and sleep fragmentation. One relevant daytime consequence of OSA is a negative impact on neurocognitive domain, ranging from psychomotor performance to executive function. In spite of a huge amount of evidence regarding cognitive impairment, little is known about perceptual processing in these patients. The aim of this research is to investigate the effects of OSA on visual mechanisms by employing a visual search paradigm. 19 OSA patients and 19 age-matched healthy controls (HC) participated in a case-control study. After a nocturnal cardiorespiratory monitoring, patients performed a visual search task in which they had to detect the presence/absence of a target (letter T) embedded in the 50% of trials into a set of distractors (letters Os, Xs, or Ls). Target's salience and distractors' numerosity were manipulated as independent variables, whereas accuracy and reaction times (RT) were recorded as dependent variables. HC, after the exclusion of any sleep disorder or sleepiness, performed the same experiments. Results generally confirmed the typical effects of visual search. OSA patients reported significantly slower RT in comparison with HC, indicating an overall perceptual deficit consisting in a harder extraction of relevant information from noise. Neither patients' age nor the objective clinical indices were associated with RT. This study indicates the presence of an impairment in OSA patients involving basic mechanisms of visual processing and likely ascribable to the disorder per se.

Saliency from orthogonal velocity component in texture segregation.

We found that a moving target line, more-vertical than 45 deg-oriented background lines, pops-out (d'=1.2) although it moves at the same speed of background elements and although it is invisible in static presentation (d'=.7). We suggest that the moving more-vertical target is more salient because the motion system responds to the orthogonal-velocity-component (V(perpendicular)=Delta d/Delta t sin theta) that is larger for the more-vertical target than for distracters. However, motion does not produce high d' when the target is more horizontal than background (d'=.6). This result is not expected if saliency resulted from the sum of saliency of orientation and motion independently coded but is instead predicted by visual search asymmetry. A line length effect on the moving target saliency also suggests that V(perpendicular) is extracted on the whole line and this operation is facilitated by line length in the same way for more-vertical and more-horizontal targets. Altogether, these results demonstrate that speed-based segmentation operating on V(perpendicular) not only affects speed and direction of motion discrimination, as previously demonstrated, but accounts for high saliency of image features that would otherwise prove undetectable of the basis of orientation-contrast.

REM sleep Behaviour Disorder.

Rapid Eye Movement (REM) sleep Behaviour Disorder (RBD) is a REM sleep parasomnia characterized by loss of the muscle atonia that typically occurs during REM sleep, therefore allowing patients to act out their dreams. RBD manifests itself clinically as a violent behaviour occurring during the night, and is detected at the polysomnography by phasic and/or tonic muscle activity on the electromyography channel. In absence of neurological signs or central nervous system lesions, RBD is defined as idiopathic. Nevertheless, in a large number of cases the development of neurodegenerative diseases in RBD patients has been described, with the duration of the follow-up representing a fundamental aspect. A growing number of clinical, neurophysiologic and neuropsychological studies aimed to detect early markers of neurodegenerative dysfunction in RBD patients. Anyway, the evidence of impaired cortical activity, subtle neurocognitive dysfunction, olfactory and autonomic impairment and neuroimaging brain changes in RBD patients is challenging the concept of an idiopathic form of RBD, supporting the idea of RBD as an early manifestation of a more complex neurodegenerative process.

Behavioural and Cognitive-Behavioural Treatments of Parasomnias.

Parasomnias are unpleasant or undesirable behaviours or experiences that occur predominantly during or within close proximity to sleep. Pharmacological treatments of parasomnias are available, but their efficacy is established only for few disorders. Furthermore, most of these disorders tend spontaneously to remit with development. Nonpharmacological treatments therefore represent valid therapeutic choices. This paper reviews behavioural and cognitive-behavioural managements employed for parasomnias. Referring to the ICSD-3 nosology we consider, respectively, NREM parasomnias, REM parasomnias, and other parasomnias. Although the efficacy of some of these treatments is proved, in other cases their clinical evidence cannot be provided because of the small size of the samples. Due to the rarity of some parasomnias, further multicentric researches are needed in order to offer a more complete account of behavioural and cognitive-behavioural treatments efficacy.

Neurocognitive function in patients with idiopathic Restless Legs Syndrome before and after treatment with dopamine-agonist.

Although a huge amount of clinical evidence for Restless Legs Syndrome (RLS) is present in literature, an exhaustive account of cognitive profile in RLS patients is still lacking. In this study we evaluated the neurocognitive function in RLS patients and the effects of a three-month treatment with a dopamine agonist (pramipexole) at low doses. Clinical and polysomnographic characteristics, cognitive abilities, quality of life and psychological clinical indices were assessed in 20 RLS patients and 15 age-matched controls. The neurocognitive results, obtained by untreated RLS patients (baseline), were firstly compared to those of controls and then to those of the same RLS group after treatment (follow-up). Increased Total Sleep Time, Slow Wave Sleep, Sleep Efficiency and decreased Sleep Latency, Wake After Sleep Onset and periodic leg movement index were found by polysomnographic recording after a three-month treatment. Results showed that cognitive functions, impaired at baseline when compared to control subjects, improved after the pharmacological treatment, reaching the scores of healthy subjects. Decision making, problem solving and categorizing abilities, investigated by the Iowa Gambling Task (IGT) and the Wisconsin Card Sorting Test (WCST), resulted lower in RLS patients at baseline than in controls. All these functions improved after pharmacological treatment, as well as quality of life, depressive and anxiety symptoms, and daytime sleepiness.

An early history of the Gestalt factors of organisation.

Wertheimer's (1923, Psychologische Forschung 4 301 - 350) idea that the perceptual world is articulated according to factors of organisation is widely acknowledged as one of the most original contributions of Gestalt psychology and stands as a milestone in the history of vision research. An inquiry focused on the forerunners of some of Wertheimer's factors of perceptual organisation is documented here. In fact, in 1900 Schumann described grouping by proximity and by vertical symmetry, and in 1903 G E Müller identified the factors of sameness/similarity and contour. Other authors contributed to the early description of these factors, such as Rubin, who in 1922 originally illustrated grouping by similarity. Even though Wertheimer himself granted these authors due recognition, later psychologists have paid little attention to their contributions. Some possible reasons for this negligence are briefly discussed.

A new motion illusion based on competition between two kinds of motion processing units: the accordion grating.

Parametric psychophysical investigations are reported for two related illusory effects that occur when viewing an elementary square-wave grating while making "back and forth" head movements along the projection line. Observers report a non-rigid distortion of the pattern, including: (i) an expansion in a direction perpendicular to the stripes, and (ii) a perceived curvature of the stripes. We investigated these two phenomena independently. The first depends on the classical physiological aperture problem that confronts early cells in the vision system. Interactions between ambiguous and unambiguous motion signals, generated at line interiors and line ends, respectively, can explain why the perceived expansion occurs only in directions perpendicular to the stripes. A simple model is presented and successfully tested by a nulling psychophysical experiment with four subjects. The experiment varies key stimulus attributes that generate ambiguous and unambiguous motion signals. Regarding the illusory curvature, a differential geometry model of the optics of our display, which identifies a non-classical three-dimensional (3D) aperture problem, is proposed (Yazdanbakhsh & Gori, 2011). We tested that model by implementing its closed form prediction of distortion to design displays for a second psychophysical experiment that also uses a nulling technique. Results from four subjects allow the quantification of the degree of perceived curvature as a function of speed, distance and stimulus type (blurred vs. unblurred grating) and are compatible with the predictions of the model.

The perceptual expansion of a filled area depends on textural characteristics.

According to the Oppel-Kundt illusion, a filled space appears larger than an empty one. In the present research we studied how textural characteristics affect the perceived size of two-dimensional patterns. We investigated the perceived extension of square textures by manipulating spatial frequency and filling microelements' numerosity. Subjects compared the test stimuli with a uniform gray square varied in size and performed the task both with the adjustment and the constant stimuli methods. An illusory increment of area extension was generally found with textured stimuli. The illusory effect increased with spatial frequency and decreased with the microelements' number, indicating an independent processing of these two basic properties. Moreover, the smaller effect found when spatial frequency extraction became harder, confirmed that the illusion involves spatial frequency processing. Finally, the reduced overestimation of areas observed with a weaker subparts' articulation confirmed the relevance of clear distinguishable micropatterns at the basis of the phenomenon. Those results demonstrate the influence of textural statistical properties on perceiving the size of a visual object.

Measuring the Breathing Light Illusion by means of induced simultaneous contrast.

By blurring the margins of a surface, both its brightness and the perceived contrast against a superimposed figure with sharp boundaries increase. Also, if one approaches a blurred white spot on a grey background, this spot will appear wider and brighter: this phenomenon is known as the Breathing Light Illusion (BLI) (Gori and Stubbs, 2006 Perception 35 1573-1577). We studied the increment of the achromatic contrast of a grey sharp-boundary disk when it was superimposed on the BLI. This augmentation of the perceived contrast in the dynamic presentation of the BLI was significantly stronger than the effect that Agostini and Galmonte (2002a Psychonomic Bulletin and Review 9 264-269) obtained in static presentation. Our study leads to an indirect quantification of the BLI. Two control experiments showed that the increment of the achromatic contrast depends on the blurred spot and is independent of the dynamic increment in angular size. These results argue for a causal relationship between the increase in brightness due to the BLI and the darkening of the superimposed disk.

Perceptual compromise between apparent and veridical motion indices: the unchained-dots illusion.

A new motion illusion based on dot-trajectory misperception is presented. The illusory effect can not be explained by the aperture problem unlike some previous illusions characterised by misperception of motion direction. We propose an explanation in terms of 'perceptual compromise' between an original type of apparent motion and the veridical motion. Several demonstrations are presented in support of that hypothesis.