Detalhe da pesquisa
1.
Fazirsiran for Liver Disease Associated with Alpha1-Antitrypsin Deficiency.
N Engl J Med
; 387(6): 514-524, 2022 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35748699
2.
A phase I/II study of ARO-HSD, an RNA interference therapeutic, for the treatment of non-alcoholic steatohepatitis.
J Hepatol
; 78(4): 684-692, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36513186
3.
Long-term serological, virological and histological responses to RNA inhibition by ARC-520 in Chinese chronic hepatitis B patients on entecavir treatment.
Gut
; 71(4): 789-797, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33712437
4.
Combination treatments including the small-interfering RNA JNJ-3989 induce rapid and sometimes prolonged viral responses in patients with CHB.
J Hepatol
; 77(5): 1287-1298, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35870702
5.
RNA Interference Therapy With ARC-520 Results in Prolonged Hepatitis B Surface Antigen Response in Patients With Chronic Hepatitis B Infection.
Hepatology
; 72(1): 19-31, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31654573
6.
Hepatic-targeted RNA interference provides robust and persistent knockdown of alpha-1 antitrypsin levels in ZZ patients.
J Hepatol
; 69(2): 378-384, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29572094
7.
RNA Interference Therapy for Chronic Hepatitis B Predicts the Importance of Addressing Viral Integration When Developing Novel Cure Strategies.
Viruses
; 13(4)2021 03 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-33808298
8.
Development of an RNAi therapeutic for alpha-1-antitrypsin liver disease.
JCI Insight
; 5(12)2020 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32379724
9.
Safety, Tolerability, and Pharmacokinetics of ARC-520 Injection, an RNA Interference-Based Therapeutic for the Treatment of Chronic Hepatitis B Virus Infection, in Healthy Volunteers.
Clin Pharmacol Drug Dev
; 6(4): 350-362, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-27739230
10.
RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg.
Sci Transl Med
; 9(409)2017 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28954926
11.
Chronic hepatitis B: Virology, natural history, current management and a glimpse at future opportunities.
Antiviral Res
; 121: 47-58, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26092643
12.
Synthetic RNAi triggers and their use in chronic hepatitis B therapies with curative intent.
Antiviral Res
; 121: 97-108, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26129970