Detalhe da pesquisa
1.
NKTR-181: A Novel Mu-Opioid Analgesic with Inherently Low Abuse Potential.
J Pharmacol Exp Ther
; 363(1): 104-113, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28778859
2.
Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI).
Bioorg Med Chem Lett
; 18(14): 4224-7, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18550369
3.
Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with improved pharmaceutical characteristics.
Bioorg Med Chem Lett
; 18(23): 6151-5, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18954981
4.
Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with a heterocyclic ring constraint.
Bioorg Med Chem Lett
; 18(16): 4495-8, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18667309
5.
Structure-activity relationships of chiral selective norepinephrine reuptake inhibitors (sNRI) with increased oxidative stability.
Bioorg Med Chem Lett
; 18(16): 4491-4, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18672364
6.
Glutamate-based therapeutic approaches: NR2B receptor antagonists.
Curr Opin Pharmacol
; 6(1): 68-74, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16376149
7.
1-(4-Amino-phenyl)-pyrrolidin-3-yl-amine and 6-(3-amino-pyrrolidin-1-yl)-pyridin-3-yl-amine derivatives as melanin-concentrating hormone receptor-1 antagonists.
Bioorg Med Chem Lett
; 15(16): 3701-6, 2005 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16005225
8.
Potent and orally active non-peptide antagonists of the human melanocortin-4 receptor based on a series of trans-2-disubstituted cyclohexylpiperazines.
Bioorg Med Chem Lett
; 15(19): 4389-95, 2005 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16098742
9.
In vivo pharmacological characterization of indiplon, a novel pyrazolopyrimidine sedative-hypnotic.
J Pharmacol Exp Ther
; 311(2): 547-59, 2004 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-15256538