Detalhe da pesquisa
1.
Drugging an undruggable pocket on KRAS.
Proc Natl Acad Sci U S A
; 116(32): 15823-15829, 2019 08 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31332011
2.
KRAS Binders Hidden in Nature.
Chemistry
; 25(52): 12037-12041, 2019 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31231840
3.
Reply to Tran et al.: Dimeric KRAS protein-protein interaction stabilizers.
Proc Natl Acad Sci U S A
; 117(7): 3365-3367, 2020 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32047042
4.
Regioselective reactions for programmable resveratrol oligomer synthesis.
Nature
; 474(7352): 461-6, 2011 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-21697944
5.
Synthesis of Indazoles via N-N Bond-Forming Oxidative Cyclization from 2-Aminomethyl-phenylamines.
Org Lett
; 26(6): 1229-1232, 2024 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38315455
6.
Inhibition of p53-MDM2 binding reduces senescent cell abundance and improves the adaptive responses of skeletal muscle from aged mice.
Geroscience
; 46(2): 2153-2176, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-37872294
7.
Kinase Degraders, Activators, and Inhibitors: Highlights and Synthesis Routes to the Chemical Probes on opnMe.com, Partâ 1.
ChemMedChem
; 18(10): e202300031, 2023 05 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36825440
8.
One-Pot Synthesis of Cereblon Proteolysis Targeting Chimeras via Photoinduced C(sp2)-C(sp3) Cross Coupling and Amide Formation for Proteolysis Targeting Chimera Library Synthesis.
J Med Chem
; 66(24): 16939-16952, 2023 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38096359
9.
Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and inâ vivo Experiments.
ChemMedChem
; 18(6): e202200686, 2023 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36649575
10.
Synthesis of MDM2-p53 Inhibitor BI-0282 via a Dipolar Cycloaddition and Late-Stage Davis-Beirut Reaction.
Org Process Res Dev
; 26(8): 2526-2531, 2022 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36032359
11.
Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRASG12C Inhibitor.
J Med Chem
; 65(21): 14614-14629, 2022 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36300829
12.
Three-step synthesis of Ethyl Canthinone-1-carboxylates from ethyl 4-bromo-6-methoxy-1,5-naphthyridine-3-carboxylate via a Pd-catalyzed Suzuki-Miyaura coupling and a Cu-catalyzed amidation reaction [corrected].
J Org Chem
; 76(12): 5113-22, 2011 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-21563779
13.
Syntheses and antibacterial properties of iso-platencin, Cl-iso-platencin and Cl-platencin: identification of a new lead structure.
Chemistry
; 16(31): 9616-22, 2010 Aug 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-20486112
14.
Correction to "Three-Step Synthesis of Ethyl Canthinone-3-carboxylates from Ethyl 4-Bromo-6-methoxy-1,5-naphthyridine-3-carboxylate via a Pd-Catalyzed Suzuki-Miyaura Coupling and a Cu-Catalyzed Amidation Reaction".
J Org Chem
; 80(17): 8942, 2015 Sep 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26293225
15.
The laulimalide family: total synthesis and biological evaluation of neolaulimalide, isolaulimalide, laulimalide and a nonnatural analogue.
Chemistry
; 15(24): 5979-97, 2009 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-19402092
16.
Targeted Synthesis of Complex Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-ones by Intramolecular Cyclization of Azomethine Ylides: Highly Potent MDM2-p53 Inhibitors.
ChemMedChem
; 14(1): 88-93, 2019 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30458062
17.
Donated chemical probes for open science.
Elife
; 72018 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29676732
18.
opnMe.com: a digital initiative for sharing tools with the biomedical research community.
Nat Rev Drug Discov
; 21(7): 475-476, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35459938
19.
Discovery of Novel Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2-p53 Interaction.
J Med Chem
; 59(22): 10147-10162, 2016 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27775892
20.
Two-step total syntheses of canthin-6-one alkaloids: new one-pot sequential Pd-catalyzed Suzuki-Miyaura coupling and Cu-catalyzed amidation reaction.
Org Lett
; 12(6): 1352-5, 2010 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-20192213