RESUMO
In young adult male rabbits circadian rhythms change of blood concentrations of adrenaline and noradrenaline in the dynamics of hypopinealism development induced by a long period (5 months) twenty-four-hour lighting of low intensity (30-40 lux) were studied. It was found that the light in the night leads to a significant increase in the levels of both catecholamines, which indicates on the activation of the sympathoadrenal system (SAS), just as it occurs in aging and stress (stress-age-syndrome by V.V. Frolkis). Daily features of SAS reactions to light stress were revealed. Based on these data it can be concluded that one of the reduction mechanisms of life expectancy at hypopinealizm is excessive and prolonged activation of SAS.
Assuntos
Senilidade Prematura/sangue , Ritmo Circadiano , Epinefrina/sangue , Iluminação , Norepinefrina/sangue , Glândula Pineal/metabolismo , Animais , Glândula Pineal/patologia , Coelhos , Estresse Psicológico/sangue , Fatores de TempoRESUMO
Administration of Cytoflavin to young rats with experimental myocardial ischemia was followed by activation of mitochondrial enzymes and significant accumulation of ATP in the myocardium and blood plasma, but did not modulate the stability of cardiomyocyte membranes and signs of hypoxia. Cytoflavin increased the severity of metabolic disorders and depleted the energy reserves of cells in old rats with myocardial ischemia.
Assuntos
Trifosfato de Adenosina/sangue , Cardiotônicos/uso terapêutico , Mononucleotídeo de Flavina/uso terapêutico , Inosina Difosfato/uso terapêutico , Mitocôndrias/enzimologia , Traumatismo por Reperfusão Miocárdica/tratamento farmacológico , Niacinamida/uso terapêutico , Succinatos/uso terapêutico , Trifosfato de Adenosina/metabolismo , Fatores Etários , Animais , Combinação de Medicamentos , Ativação Enzimática/efeitos dos fármacos , Masculino , Traumatismo por Reperfusão Miocárdica/fisiopatologia , Miocárdio/citologia , Miócitos Cardíacos/citologia , Miócitos Cardíacos/fisiologia , Ratos , Ratos WistarRESUMO
Under experimental myocardial ischemia in rats of 10 months treatment with mildronate resulted in essential changes in metabolism of cardiomyocites. This includes stimulation of aerobic and anaerobic ways of power supply of heart cells: activation of glycolysis, oxidative phosphorylation and oxidative pyruvate decarboxylation with restoration of adenosine triphosphate pool to intact rats level in myocardium, serum and erythrocytes with signs of stabilization of cardiomyocytes membranes and essential decrease of tissue hypoxia. Introduction of mildronate to old rats (24 months) with an experimental myocardium ischemia was accompanied by lesser expressed changes of metabolism: activation of glycolysis and oxidative pyruvate decarboxylation without stimulation of Crebs' cycle enzymes. This became sufficient for restoration of adenosine triphosphate pool in myocardium without change of its quantity in serum and erythrocytes with signs of stabilization of cardiomyocytes membranes and moderate reduction of tissue hypoxia degree.
Assuntos
Fármacos Cardiovasculares/farmacologia , Metilidrazinas/farmacologia , Isquemia Miocárdica/tratamento farmacológico , Isquemia Miocárdica/metabolismo , Miócitos Cardíacos/efeitos dos fármacos , Miócitos Cardíacos/metabolismo , 2,3-Difosfoglicerato/metabolismo , Trifosfato de Adenosina/metabolismo , Fatores Etários , Animais , Creatina Quinase/metabolismo , Descarboxilação , Metabolismo Energético/efeitos dos fármacos , Glicólise , Isoenzimas/sangue , L-Lactato Desidrogenase/sangue , Masculino , Isquemia Miocárdica/patologia , Piruvatos/metabolismo , Ratos , Ratos WistarRESUMO
Introduction of trimetazidine to 10-month-aged rats with experimental ischemic heart disease leads to an increase in carbohydrate utilization with energy purposes in myocardium, which is manifested by increasing activity of glycolysis enzymes with decreasing lactate level in myocardium, increasing activity of pyruvate dehydrogenase and citrate synthase in mitochondrial cardiomyocytes, and increasing ATP content in myocardium. This is accompanied by signs of stabilization of cardiomyocyte membranes and reduction in the degree of tissue hypoxia. The efficiency of trimetazidine decreases with increasing age: in 24-month-aged rats, the direction of changes is retained, but they are less pronounced.