Pesquisa | BVS Violência e Saúde

1.

CTLA4, SH2B3, and CLEC16A diversely affect the progression of early islet autoimmunity in relatives of Type 1 diabetes patients.

Vandewalle, Julie; Desouter, Aster K; Van der Auwera, Bart J; Tenoutasse, Sylvie; Gillard, Pieter; De Block, Christophe; Keymeulen, Bart; Gorus, Frans K; Van de Casteele, Mark.

Clin Exp Immunol ; 211(3): 224-232, 2023 03 24.

Artigo em Inglês | MEDLINE | ID: mdl-36622793

2.

Genetic variation at ERBB3/IKZF4 and sexual dimorphism in epitope spreading in single autoantibody-positive relatives.

Vandewalle, Julie; Van der Auwera, Bart J; Amin, Henna; Quartier, Erik; Desouter, Aster K; Tenoutasse, Sylvie; Gillard, Pieter; De Block, Christophe; Keymeulen, Bart; Gorus, Frans K; Van de Casteele, Mark.

Diabetologia ; 64(11): 2511-2516, 2021 11.

Artigo em Inglês | MEDLINE | ID: mdl-34448034

3.

A randomised, single-blind, placebo-controlled, dose-finding safety and tolerability study of the anti-CD3 monoclonal antibody otelixizumab in new-onset type 1 diabetes.

Keymeulen, Bart; van Maurik, André; Inman, Dave; Oliveira, João; McLaughlin, Rene; Gittelman, Rachel M; Roep, Bart O; Gillard, Pieter; Hilbrands, Robert; Gorus, Frans; Mathieu, Chantal; Van de Velde, Ursule; Wisniacki, Nicolas; Napolitano, Antonella.

Diabetologia ; 64(2): 313-324, 2021 02.

Artigo em Inglês | MEDLINE | ID: mdl-33145642

4.

SLC30A8 polymorphism and BMI complement HLA-A*24 as risk factors for poor graft function in islet allograft recipients.

Balke, Else M; Demeester, Simke; Lee, DaHae; Gillard, Pieter; Hilbrands, Robert; Van de Velde, Ursule; Van der Auwera, Bart J; Ling, Zhidong; Roep, Bart O; Pipeleers, Daniël G; Keymeulen, Bart; Gorus, Frans K.

Diabetologia ; 61(7): 1623-1632, 2018 07.

Artigo em Inglês | MEDLINE | ID: mdl-29679103

5.

Relationship between glycaemic variability and hyperglycaemic clamp-derived functional variables in (impending) type 1 diabetes.

Van Dalem, Annelien; Demeester, Simke; Balti, Eric V; Decochez, Katelijn; Weets, Ilse; Vandemeulebroucke, Evy; Van de Velde, Ursule; Walgraeve, An; Seret, Nicole; De Block, Christophe; Ruige, Johannes; Gillard, Pieter; Keymeulen, Bart; Pipeleers, Daniel G; Gorus, Frans K.

Diabetologia ; 58(12): 2753-64, 2015 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-26409458

6.

Enhanced anti-serpin antibody activity inhibits autoimmune inflammation in type 1 diabetes.

Czyzyk, Jan; Henegariu, Octavian; Preston-Hurlburt, Paula; Baldzizhar, Raman; Fedorchuk, Christine; Esplugues, Enric; Bottomly, Kim; Gorus, Frans K; Herold, Kevan; Flavell, Richard A.

J Immunol ; 188(12): 6319-27, 2012 Jun 15.

Artigo em Inglês | MEDLINE | ID: mdl-22593614

7.

Alternative splicing and differential expression of the islet autoantigen IGRP between pancreas and thymus contributes to immunogenicity of pancreatic islets but not diabetogenicity in humans.

de Jong, V Martijn; Abreu, Joana R F; Verrijn Stuart, Annemarie A; van der Slik, Arno R; Verhaeghen, Katrijn; Engelse, Marten A; Blom, Bianca; Staal, Frank J T; Gorus, Frans K; Roep, Bart O.

Diabetologia ; 56(12): 2651-8, 2013 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-24030068

8.

Long-term stability of laboratory tests and practical implications for quality management.

Van Houcke, Sofie K; Stepman, Hedwig C M; Thienpont, Linda M; Fiers, Tom; Stove, Veronique; Couck, Pedro; Anckaert, Ellen; Gorus, Frans.

Clin Chem Lab Med ; 51(6): 1227-31, 2013 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-23337057

9.

Baseline plasma proinsulin response to glucose for predicting therapeutic response to otelixizumab in recent-onset type 1 diabetes.

Desouter, Aster K; Keymeulen, Bart; Demeester, Simke; Van de Velde, Ursule; De Pauw, Pieter; Van Dalem, Annelien; Lapauw, Bruno; De Block, Christophe; Gillard, Pieter; Pipeleers, Daniel G; Gorus, Frans K.

Diabetes Res Clin Pract ; 205: 110974, 2023 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-37884063

10.

Enzymatic pyruvate measurement by Cobas 6000 open channel assay.

Van den Bossche, Dorien; Schiettecatte, Johan; Vekens, Evilien; De Smet, Dieter; Gorus, Frans K; Martens, Geert A.

Clin Lab ; 58(9-10): 1091-5, 2012.

Artigo em Inglês | MEDLINE | ID: mdl-23163130

11.

The MicroRNA Landscape of Acute Beta Cell Destruction in Type 1 Diabetic Recipients of Intraportal Islet Grafts.

Martens, Geert A; Stangé, Geert; Piemonti, Lorenzo; Anckaert, Jasper; Ling, Zhidong; Pipeleers, Daniel G; Gorus, Frans K; Mestdagh, Pieter; De Smet, Dieter; Vandesompele, Jo; Keymeulen, Bart; Roels, Sarah.

Cells ; 10(7)2021 07 04.

Artigo em Inglês | MEDLINE | ID: mdl-34359863

12.

Insulitis in the pancreas of non-diabetic organ donors under age 25 years with multiple circulating autoantibodies against islet cell antigens.

Smeets, Silke; De Paep, Diedert Luc; Stangé, Geert; Verhaeghen, Katrijn; Van der Auwera, Bart; Keymeulen, Bart; Weets, Ilse; Ling, Zhidong; In't Veld, Peter; Gorus, Frans.

Virchows Arch ; 479(2): 295-304, 2021 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-33594586

13.

Development of a multipurpose time-resolved fluorescence immunoassay for rat insulin.

van Genderen, Farah T; Gorus, Frans K; Vermeulen, Ilse; Vekens, Evilien M F; De Pauw, Pieter E M; Pipeleers, Daniel G; Van Schravendijk, Chris.

Anal Biochem ; 404(1): 8-13, 2010 Sep 01.

Artigo em Inglês | MEDLINE | ID: mdl-20417610

14.

Combined Analysis of GAD65, miR-375, and Unmethylated Insulin DNA Following Islet Transplantation in Patients With T1D.

Roels, Sarah; Costa, Olivier R; Tersey, Sarah A; Stangé, Geert; De Smet, Dieter; Balti, Eric V; Gillard, Pieter; Keymeulen, Bart; Ling, Zhidong; Pipeleers, Daniel G; Gorus, Frans K; Mirmira, Raghavendra G; Martens, Geert A.

J Clin Endocrinol Metab ; 104(2): 451-460, 2019 02 01.

Artigo em Inglês | MEDLINE | ID: mdl-30203041

15.

Immune checkpoint inhibitors and type 1 diabetes mellitus: a case report and systematic review.

de Filette, Jeroen M K; Pen, Joeri J; Decoster, Lore; Vissers, Thomas; Bravenboer, Bert; Van der Auwera, Bart J; Gorus, Frans K; Roep, Bart O; Aspeslagh, Sandrine; Neyns, Bart; Velkeniers, Brigitte; Kharagjitsingh, Aan V.

Eur J Endocrinol ; 181(3): 363-374, 2019 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-31330498

16.

A composite immune signature parallels disease progression across T1D subjects.

Speake, Cate; Skinner, Samuel O; Berel, Dror; Whalen, Elizabeth; Dufort, Matthew J; Young, William Chad; Odegard, Jared M; Pesenacker, Anne M; Gorus, Frans K; James, Eddie A; Levings, Megan K; Linsley, Peter S; Akirav, Eitan M; Pugliese, Alberto; Hessner, Martin J; Nepom, Gerald T; Gottardo, Raphael; Long, S Alice.

JCI Insight ; 4(23)2019 12 05.

Artigo em Inglês | MEDLINE | ID: mdl-31671072

17.

Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes.

Keymeulen, Bart; Vandemeulebroucke, Evy; Ziegler, Anette G; Mathieu, Chantal; Kaufman, Leonard; Hale, Geoff; Gorus, Frans; Goldman, Michel; Walter, Markus; Candon, Sophie; Schandene, Liliane; Crenier, Laurent; De Block, Christophe; Seigneurin, Jean-Marie; De Pauw, Pieter; Pierard, Denis; Weets, Ilse; Rebello, Peppy; Bird, Pru; Berrie, Eleanor; Frewin, Mark; Waldmann, Herman; Bach, Jean-François; Pipeleers, Daniel; Chatenoud, Lucienne.

N Engl J Med ; 352(25): 2598-608, 2005 Jun 23.

Artigo em Inglês | MEDLINE | ID: mdl-15972866

18.

Comparison of sirolimus alone with sirolimus plus tacrolimus in type 1 diabetic recipients of cultured islet cell grafts.

Gillard, Pieter; Ling, Zhidong; Mathieu, Chantal; Crenier, Laurent; Lannoo, Matthias; Maes, Bart; Roep, Bart; Gorus, Frans; Pipeleers, Daniel; Keymeulen, Bart.

Transplantation ; 85(2): 256-63, 2008 Jan 27.

Artigo em Inglês | MEDLINE | ID: mdl-18212631

19.

Simultaneous measurement of plasma concentrations of proinsulin and C-peptide and their ratio with a trefoil-type time-resolved fluorescence immunoassay.

De Pauw, Pieter E M; Vermeulen, Ilse; Ubani, Ogonnaya C; Truyen, Inge; Vekens, Evilien M F; van Genderen, Farah T; De Grijse, Joeri W; Pipeleers, Daniel G; Van Schravendijk, Chris; Gorus, Frans K.

Clin Chem ; 54(12): 1990-8, 2008 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-18845769

20.

The beta cell population in type 1 diabetes.

Pipeleers, Daniel; In't Veld, Peter; Pipeleers-Marichal, Miriam; Gorus, Frans.

Novartis Found Symp ; 292: 19-24; discussion 24-31, 122-9, 202-3, 2008.

Artigo em Inglês | MEDLINE | ID: mdl-19203090

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