Pesquisa | BVS Violência e Saúde

1.

Seizure reduction in TSC2-mutant mouse model by an mTOR catalytic inhibitor.

Dhamne, Sameer C; Modi, Meera E; Gray, Audrey; Bonazzi, Simone; Craig, Lucas; Bainbridge, Elizabeth; Lalani, Lahin; Super, Chloe E; Schaeffer, Samantha; Capre, Ketthsy; Lubicka, Danuta; Liang, Guiqing; Burdette, Doug; McTighe, Stephanie M; Gurnani, Sarika; Vermudez, Sheryl Anne D; Curtis, Daniel; Wilson, Christopher J; Hameed, Mustafa Q; D'Amore, Angelica; Rotenberg, Alexander; Sahin, Mustafa.

Ann Clin Transl Neurol ; 10(10): 1790-1801, 2023 10.

Artigo em Inglês | MEDLINE | ID: mdl-37545094

2.

Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes.

Bonazzi, Simone; Gray, Audrey; Thomsen, Noel M; Biag, Jonathan; Labbe-Giguere, Nancy; Keaney, Erin P; Malik, Hasnain A; Sun, Yingchuan; Nunez, Jill; Karki, Rajeshri G; Knapp, Mark; Elling, Robert; Fuller, John; Pardee, Gwynn; Craig, Lucas; Capre, Ketthsy; Salas, Sarah; Gorde, Aakruti; Liang, Guiqing; Lubicka, Danuta; McTighe, Stephanie M; Goold, Carleton; Liu, Shanming; Deng, Lin; Hong, Jin; Fekete, Alexander; Stadelmann, Pascal; Frieauff, Wilfried; Elhajouji, Azeddine; Bauer, Daniel; Lerchner, Andreas; Radetich, Branko; Furet, Pascal; Piizzi, Grazia; Burdette, Doug; Wilson, Christopher J; Peukert, Stefan; Hamann, Lawrence G; Murphy, Leon O; Curtis, Daniel.

J Med Chem ; 66(13): 9095-9119, 2023 07 13.

Artigo em Inglês | MEDLINE | ID: mdl-37399505

3.

Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons.

Sanchez, Carlos G; Acker, Christopher M; Gray, Audrey; Varadarajan, Malini; Song, Cheng; Cochran, Nadire R; Paula, Steven; Lindeman, Alicia; An, Shaojian; McAllister, Gregory; Alford, John; Reece-Hoyes, John; Russ, Carsten; Craig, Lucas; Capre, Ketthsy; Doherty, Christian; Hoffman, Gregory R; Luchansky, Sarah J; Polydoro, Manuela; Dolmetsch, Ricardo; Elwood, Fiona.

Commun Biol ; 4(1): 736, 2021 06 14.

Artigo em Inglês | MEDLINE | ID: mdl-34127790

4.

Oral treatment with a gamma-secretase inhibitor improves long-term potentiation in a mouse model of Alzheimer's disease.

Townsend, Matthew; Qu, Yujie; Gray, Audrey; Wu, Zhenhua; Seto, Tiffany; Hutton, Mike; Shearman, Mark S; Middleton, Richard E.

J Pharmacol Exp Ther ; 333(1): 110-9, 2010 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-20056779

5.

Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders.

Bonazzi, Simone; Goold, Carleton P; Gray, Audrey; Thomsen, Noel M; Nunez, Jill; Karki, Rajeshri G; Gorde, Aakruti; Biag, Jonathan D; Malik, Hasnain A; Sun, Yingchuan; Liang, Guiqing; Lubicka, Danuta; Salas, Sarah; Labbe-Giguere, Nancy; Keaney, Erin P; McTighe, Stephanie; Liu, Shanming; Deng, Lin; Piizzi, Grazia; Lombardo, Franco; Burdette, Doug; Dodart, Jean-Cosme; Wilson, Christopher J; Peukert, Stefan; Curtis, Daniel; Hamann, Lawrence G; Murphy, Leon O.

J Med Chem ; 63(3): 1068-1083, 2020 02 13.

Artigo em Inglês | MEDLINE | ID: mdl-31955578

6.

The relationship of plasma Abeta levels to dementia in aging individuals with Down syndrome.

Matsuoka, Yasuji; Andrews, Howard F; Becker, Amanda G; Gray, Audrey J; Mehta, Pankaj D; Sano, Mary C; Dalton, Arthur J; Aisen, Paul S.

Alzheimer Dis Assoc Disord ; 23(4): 315-8, 2009.

Artigo em Inglês | MEDLINE | ID: mdl-19571732

7.

A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease.

Matsuoka, Yasuji; Jouroukhin, Yan; Gray, Audrey J; Ma, Li; Hirata-Fukae, Chiho; Li, Hui-Fang; Feng, Li; Lecanu, Laurent; Walker, Benjamin R; Planel, Emmanuel; Arancio, Ottavio; Gozes, Illana; Aisen, Paul S.

J Pharmacol Exp Ther ; 325(1): 146-53, 2008 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-18199809

8.

Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model.

Hirata-Fukae, Chiho; Li, Hui-Fang; Hoe, Hyang-Sook; Gray, Audrey J; Minami, S Sakura; Hamada, Katsuyoshi; Niikura, Takako; Hua, Fang; Tsukagoshi-Nagai, Hiroe; Horikoshi-Sakuraba, Yuko; Mughal, Mohamed; Rebeck, G William; LaFerla, Frank M; Mattson, Mark P; Iwata, Nobuhisa; Saido, Takaomi C; Klein, William L; Duff, Karen E; Aisen, Paul S; Matsuoka, Yasuji.

Brain Res ; 1216: 92-103, 2008 Jun 24.

Artigo em Inglês | MEDLINE | ID: mdl-18486110

9.

Kaleidoscope.

Gray, Audrey.

AMA J Ethics ; 20(9): E894-896, 2018 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-30242822

10.

Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage.

Matsuoka, Yasuji; Gray, Audrey J; Hirata-Fukae, Chiho; Minami, S Sakura; Waterhouse, Emily Graeme; Mattson, Mark P; LaFerla, Frank M; Gozes, Illana; Aisen, Paul S.

J Mol Neurosci ; 31(2): 165-70, 2007.

Artigo em Inglês | MEDLINE | ID: mdl-17478890

11.

Antibody against C-terminal Abeta selectively elevates plasma Abeta.

Gray, Audrey J; Sakaguchi, Gaku; Shiratori, Chiharu; Becker, Amanda G; LaFrancois, John; Aisen, Paul S; Duff, Karen; Matsuoka, Yasuji.

Neuroreport ; 18(3): 293-6, 2007 Feb 12.

Artigo em Inglês | MEDLINE | ID: mdl-17314674

12.

An Abeta sequestration approach using non-antibody Abeta binding agents.

Matsuoka, Yasuji; Shao, Li; Debnath, Manik; Lafrancois, John; Becker, Amanda; Gray, Audrey; Aisen, Paul; Mathis, Chester; Klunk, William; Duff, Karen.

Curr Alzheimer Res ; 2(2): 265-8, 2005 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-15974928

13.

Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy.

Graham, Danielle L; Gray, Audrey J; Joyce, John A; Yu, Dongzi; O'Moore, Jill; Carlson, George A; Shearman, Mark S; Dellovade, Tammy L; Hering, Heike.

Neuropharmacology ; 79: 307-13, 2014 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-24326295

14.

Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400.

Cameron, Andrew; Giacomozzi, Brandy; Joyce, John; Gray, Audrey; Graham, Danielle; Ousson, Solenne; Neny, Maud; Beher, Dirk; Carlson, George; O'Moore, Jill; Shearman, Mark; Hering, Heike.

FEBS Lett ; 587(22): 3722-8, 2013 Nov 15.

Artigo em Inglês | MEDLINE | ID: mdl-24113653

15.

Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD mice.

Nelson, Rhonda L; Guo, Zhihong; Halagappa, Veerendra Madala; Pearson, Michelle; Gray, Audrey J; Matsuoka, Yasuji; Brown, Martin; Martin, Bronwen; Iyun, Titilola; Maudsley, Stuart; Clark, Robert F; Mattson, Mark P.

Exp Neurol ; 205(1): 166-76, 2007 May.

Artigo em Inglês | MEDLINE | ID: mdl-17368447

16.

Deglycosylated anti-amyloid beta antibodies reduce microglial phagocytosis and cytokine production while retaining the capacity to induce amyloid beta sequestration.

Takata, Kazuyuki; Hirata-Fukae, Chiho; Becker, Amanda G; Chishiro, Saori; Gray, Audrey J; Nishitomi, Kouhei; Franz, Andreas H; Sakaguchi, Gaku; Kato, Akira; Mattson, Mark P; Laferla, Frank M; Aisen, Paul S; Kitamura, Yoshihisa; Matsuoka, Yasuji.

Eur J Neurosci ; 26(9): 2458-68, 2007 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-17970733

17.

BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.

Nishitomi, Kouhei; Sakaguchi, Gaku; Horikoshi, Yuko; Gray, Audrey J; Maeda, Masahiro; Hirata-Fukae, Chiho; Becker, Amanda G; Hosono, Motoko; Sakaguchi, Isako; Minami, S Sakura; Nakajima, Yoshihiro; Li, Hui-Fang; Takeyama, Chie; Kihara, Tsuyoshi; Ota, Akinobu; Wong, Philip C; Aisen, Paul S; Kato, Akira; Kinoshita, Noriaki; Matsuoka, Yasuji.

J Neurochem ; 99(6): 1555-63, 2006 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-17083447

18.

Development of Abeta terminal end-specific antibodies and sensitive ELISA for Abeta variant.

Horikoshi, Yuko; Sakaguchi, Gaku; Becker, Amanda G; Gray, Audrey J; Duff, Karen; Aisen, Paul S; Yamaguchi, Haruyasu; Maeda, Masahiro; Kinoshita, Noriaki; Matsuoka, Yasuji.

Biochem Biophys Res Commun ; 319(3): 733-7, 2004 Jul 02.

Artigo em Inglês | MEDLINE | ID: mdl-15184044

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