Detalhe da pesquisa
1.
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS.
Acta Neuropathol
; 147(1): 50, 2024 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38443601
2.
Distinct neuroinflammatory signatures exist across genetic and sporadic amyotrophic lateral sclerosis cohorts.
Brain
; 146(12): 5124-5138, 2023 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37450566
3.
NLRP3 inflammasome as a key molecular target underlying cognitive resilience in amyotrophic lateral sclerosis.
J Pathol
; 256(3): 262-268, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34883532
4.
Random forest modelling demonstrates microglial and protein misfolding features to be key phenotypic markers in C9orf72-ALS.
J Pathol
; 258(4): 366-381, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36070099
5.
Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis.
Acta Neuropathol
; 141(2): 257-279, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33398403
6.
Dysregulation of AMPA receptor subunit expression in sporadic ALS post-mortem brain.
J Pathol
; 250(1): 67-78, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31579943
7.
Executive, language and fluency dysfunction are markers of localised TDP-43 cerebral pathology in non-demented ALS.
J Neurol Neurosurg Psychiatry
; 91(2): 149-157, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31515300
8.
The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity.
Hum Mol Genet
; 25(18): 3908-3924, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27466192
9.
TDP-43 as a potential biomarker for amyotrophic lateral sclerosis: a systematic review and meta-analysis.
BMC Neurol
; 18(1): 90, 2018 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29954341
10.
Amygdala TDP-43 pathology is associated with behavioural dysfunction and ferritin accumulation in amyotrophic lateral sclerosis.
bioRxiv
; 2024 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38854008
11.
The role of circulating viral and tumour DNA in the diagnosis and management of HPV associated anogenital cancers, a systematic review and meta-analysis.
J Clin Virol
; 164: 105469, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37163963
12.
pTDP-43 aggregates accumulate in non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis: a case series linking archival surgical biopsies with clinical phenotypic data.
J Pathol Clin Res
; 9(1): 44-55, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36226890
13.
Systematic, comprehensive, evidence-based approach to identify neuroprotective interventions for motor neuron disease: using systematic reviews to inform expert consensus.
BMJ Open
; 13(2): e064169, 2023 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36725099
14.
Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease.
BMJ Open
; 12(7): e064173, 2022 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35798516
15.
40 Years of CSF Toxicity Studies in ALS: What Have We Learnt About ALS Pathophysiology?
Front Mol Neurosci
; 14: 647895, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33815058
16.
Dysregulation in Subcellular Localization of Myelin Basic Protein mRNA Does Not Result in Altered Myelination in Amyotrophic Lateral Sclerosis.
Front Neurosci
; 15: 705306, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34539336
17.
Transactive response DNA-binding protein-43 proteinopathy in oligodendrocytes revealed using an induced pluripotent stem cell model.
Brain Commun
; 3(4): fcab255, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-35350711
18.
Clinical trials in amyotrophic lateral sclerosis: a systematic review and perspective.
Brain Commun
; 3(4): fcab242, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34901853
19.
Cerebrospinal fluid cytotoxicity in amyotrophic lateral sclerosis: a systematic review of in vitro studies.
Brain Commun
; 2(2): fcaa121, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33094283
20.
Improved detection of RNA foci in C9orf72 amyotrophic lateral sclerosis post-mortem tissue using BaseScope™ shows a lack of association with cognitive dysfunction.
Brain Commun
; 2(1): fcaa009, 2020 01 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-32226938