Detalhe da pesquisa
1.
Design, synthesis and biological evaluation of novel cyclic malonamide derivatives as selective RIPK1 inhibitors.
Bioorg Med Chem Lett
; 100: 129643, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38316369
2.
6-Aryl-quinazolines as novel GABAB receptor positive allosteric modulators.
Bioorg Med Chem Lett
; 67: 128714, 2022 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35367591
3.
A Mechanistic Study on the Formation of Dronic Acids.
Molecules
; 26(24)2021 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34946669
4.
C-N Bond Formation by Consecutive Continuous-Flow Reductions towards A Medicinally Relevant Piperazine Derivative.
Molecules
; 26(7)2021 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33918489
5.
Discovery of novel steroidal histamine H3 receptor antagonists/inverse agonists. Part 2. Versatile steroidal carboxamide derivatives.
Bioorg Med Chem Lett
; 29(20): 126643, 2019 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31492518
6.
Biomimetic Synthesis of Drug Metabolites in Batch and Continuous-Flow Reactors.
Chemistry
; 24(37): 9385-9392, 2018 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29736963
7.
Discovery of novel steroidal histamine H3 receptor antagonists/inverse agonists.
Bioorg Med Chem Lett
; 27(19): 4525-4530, 2017 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28888822
8.
The route from problem to solution in multistep continuous flow synthesis of pharmaceutical compounds.
Bioorg Med Chem
; 25(23): 6180-6189, 2017 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28087127
9.
Continuous Synthesis and Purification by Coupling a Multistep Flow Reaction with Centrifugal Partition Chromatography.
Angew Chem Int Ed Engl
; 56(30): 8742-8745, 2017 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28548374
10.
Charting the chemical space around the (iso)indoline scaffold, a comprehensive approach towards multitarget directed ligands.
Bioorg Med Chem Lett
; 26(17): 4211-5, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27496213
11.
4-Aryl-3-arylsulfonyl-quinolines as negative allosteric modulators of metabotropic GluR5 receptors: From HTS hit to development candidate.
Bioorg Med Chem Lett
; 26(4): 1249-52, 2016 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26774652
12.
Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents.
Molecules
; 21(8)2016 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27529200
13.
Thieno[2,3-b]pyridines as negative allosteric modulators of metabotropic GluR5 receptors: Lead optimization.
Bioorg Med Chem Lett
; 25(8): 1724-1729, 2015 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25791451
14.
Thieno[2,3-b]pyridines as negative allosteric modulators of metabotropic GluR5 receptors: hit-to-lead optimization.
Bioorg Med Chem Lett
; 24(16): 3845-9, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25017030
15.
Discovery and Characterization of RGH-122, a Potent, Selective, and Orally Bioavailable V1a Receptor Antagonist.
J Med Chem
; 67(1): 643-673, 2024 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38165765
16.
Discovery of Novel Steroid-Based Histamine H3 Receptor Antagonists/Inverse Agonists.
J Med Chem
; 67(5): 3643-3667, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38393759
17.
Novel-Type GABAB PAMs: Structure-Activity Relationship in Light of the Protein Structure.
ACS Med Chem Lett
; 15(3): 396-405, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38505850
18.
Optimization of Novel α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators and the Discovery of a Preclinical Development Candidate Molecule (RGH-560).
J Med Chem
; 66(23): 16276-16302, 2023 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37989278
19.
Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors.
Bioorg Med Chem Lett
; 22(10): 3437-40, 2012 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22537450
20.
hERG Optimization of Benzofuro-Pyridine and Pyrazino-Indole Derivatives as MCHR1 Antagonists.
ChemMedChem
; 17(7): e202100707, 2022 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35041296