RESUMO
BACKGROUND AND PURPOSE: To assess the prevalence of vigilance disorders in Parkinson's disease patients, relate the observed phenomena to potential causes and confirm these troubles with polysomnographic analysis. PATIENTS AND METHODS: A questionnaire was used to gather information on demographic data, previous and current treatments, disease characteristics, sleep and vigilance troubles. Somnolence was measured using the Epworth Sleepiness Scale (ESS). Nocturnal polysomnography (PSG) and multiple sleep latency tests (MSLT) were performed for a sample of parkinsonian patients. RESULTS: Two hundred twenty-two parkinsonian patients completed the questionnaire, and 36 patients had objective analyses. Of the patients, 43.2% had an ESS score >10, and 28.4% reported somnolence in the hour after taking dopaminergic drugs, whereas 6.8% reported unintended sleep episodes. In view of questionnaire data, these vigilance disorders may be partly explained not only by the impact of nocturnal sleep disorders (e.g. sleep apnea syndromes) but also by dopaminergic therapy (especially with dopaminergic agonists). With PSG and MSLT results, we have shown a significant correlation between mean sleep latency and ESS score. Patients with unintended sleep episodes have severe sleepiness in MSLT compared with others patients. CONCLUSIONS: Vigilance disorders are frequently observed in Parkinson's disease. We recommend informing patients of the risk of occurrence of such conditions, notably for patients with unintended sleep episodes and with sleepiness in the hour after taking dopaminergic drugs.
Assuntos
Nível de Alerta/fisiologia , Distúrbios do Sono por Sonolência Excessiva/fisiopatologia , Doença de Parkinson/fisiopatologia , Idoso , Nível de Alerta/efeitos dos fármacos , Distúrbios do Sono por Sonolência Excessiva/epidemiologia , Dopaminérgicos/efeitos adversos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Polissonografia , Estudos Prospectivos , Síndromes da Apneia do Sono , Inquéritos e QuestionáriosRESUMO
After the completion of a voluntary movement, a synchronization of cortical beta rhythms is recorded over the contralateral central region, which is assumed to reflect the termination of the motor command. In order to test this hypothesis, we compared in eight healthy subjects the synchronization of EEG beta rhythms following active and passive index extension. The passive movement was also performed after deafferentation by ischaemic nerve block in three subjects. Beta synchronization was present in all subjects after both active and passive movements, and disappeared under ischaemia in all three subjects. Post-movement beta synchronization can not solely be explained by an idling motor cortex. It may also, at least in part, reflect a movement-related somatosensory processing.
Assuntos
Vias Aferentes/fisiologia , Sincronização Cortical , Córtex Motor/fisiologia , Movimento/fisiologia , Sensação/fisiologia , Privação Sensorial/fisiologia , Córtex Somatossensorial/fisiologia , Adulto , Eletromiografia , Retroalimentação/fisiologia , Humanos , Pessoa de Meia-Idade , Contração Muscular/fisiologia , Músculo Esquelético/inervação , Músculo Esquelético/fisiologia , Tempo de Reação/fisiologiaRESUMO
Magnetic stimulation of the brain and cervical and lumbar spinal roots was performed on 50 healthy volunteers. Compound muscle action potentials (CMAPs) were recorded from biceps brachii, abductor digiti minimi (ADM), rectus femoris and tibialis anterior (TA). We assessed central conduction times by subtraction of peripheral from central latencies and compared results using either spinal root stimulation or the F-wave method. Side-to-side differences of total conduction time, peripheral conduction time and central conduction time (CCT) were measured and the effect of clockwise vs counterclockwise stimulations on latencies and sizes of CMAPs is emphasized. Amplitudes and areas of CMAPs were expressed as a percentage of the peripheral M response for ADM and TA. There was a positive correlation between CCT to the lumbosacral region and height, but not between the cervical region and height. No correlation was observed between genders and central conduction times, amplitudes or areas of CMAPs.
Assuntos
Potenciais Evocados , Magnetismo , Nervos Periféricos/fisiologia , Potenciais de Ação , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Condução Nervosa , Tempo de Reação , Valores de Referência , Raízes Nervosas Espinhais/fisiologiaRESUMO
OBJECTIVE: Sleep disturbances are frequently observed in Parkinson's disease (PD). Bilateral chronic subthalamic nucleus (STN) stimulation is an alternative treatment for advanced PD. Improvements in motor disturbances after STN stimulation are well documented and seem to be associated with better sleep quality, even though the objective effect on sleep structure remains unclear. We have therefore studied the sleep/wakefulness cycle before and after surgical treatment in 10 consecutive parkinsonian patients. METHODS: Subjective sleep quality and sleep recordings were evaluated one month before and three months after initiation of STN stimulation. After surgery, the recordings were performed under two conditions: with stimulation (the "on" condition) and-if patients had given their consent-in the absence of stimulation (the "off" condition). RESULTS: With STN stimulation, subjective and objective sleep qualities were improved. Total sleep time, sleep efficiency and the durations of deep slow wave sleep and paradoxical sleep increased significantly. When stimulation was absent, sleep disturbances were similar to those observed before surgery. CONCLUSION: Chronic STN stimulation is associated with a sleep improvement, which can be explained in part by the concomitant decrease in motor disturbances but also by the reduction in dosages of antiparkinsonian medication. However, we can not exclude a direct effect of STN stimulation on sleep regulatory centres.
Assuntos
Terapia por Estimulação Elétrica , Doença de Parkinson/complicações , Doença de Parkinson/terapia , Transtornos do Sono-Vigília/etiologia , Transtornos do Sono-Vigília/terapia , Núcleo Subtalâmico/fisiopatologia , Idoso , Transtorno Depressivo/tratamento farmacológico , Transtorno Depressivo/etiologia , Transtorno Depressivo/fisiopatologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Polissonografia , Psicotrópicos/uso terapêutico , Sono/fisiologia , Sono REM/fisiologia , Núcleo Subtalâmico/cirurgia , Resultado do Tratamento , Vigília/fisiologiaRESUMO
Chronic bilateral internal globus pallidus (GPi) stimulation allows control of levodopa induced dyskinesias (LID) and motor symptoms in severe Parkinson's disease (PD). The effect on gait has not been clearly established. Different results have been reported, mostly consisting of clinical data. The aim of this study was to evaluate, by means of a video motion analysis system (optoelectronic VICON system), the influence of bilateral GPi stimulation on gait in PD. Five patients underwent bilateral GPi stimulation. The preoperative and postoperative (3 months after surgery) clinical gait disturbances (items 29 and 30 of the motor UPDRS), as well as spatial and temporal gait measurements (namely cadence, velocity, stride and step times, single and double limb support times, stride and step lengths) were analysed in off condition (the patient had received no treatment for 12 hours or merely the lowest dose of levodopa allowing him to walk for the gait analysis) and in the on drug condition (after administration of 200 mg of levodopa). The gait analysis was performed with the VICON system. In off condition, there was a statistically significant improvement after surgery for UPDRS III and gait (clinically assessed). In on drug condition, there was a significant improvement for LID whereas UPDRS III and clinical assessment of gait were unchanged. The VICON system also showed that surgery improved gait especially in off condition, but also in on drug condition. Our method allowed exact quantification of the influence of surgery on gait characteristics. As compared with levodopa treatment, the effect of stimulation seems to be different. Indeed, the results suggest only limited effects of pallidal stimulation on the control of stride length and rather point to compensatory additional mechanisms.
Assuntos
Antiparkinsonianos/farmacologia , Discinesias/etiologia , Terapia por Estimulação Elétrica , Marcha , Globo Pálido/fisiologia , Levodopa/farmacologia , Doença de Parkinson/terapia , Idoso , Feminino , Humanos , Cinética , Masculino , Pessoa de Meia-Idade , Índice de Gravidade de Doença , Resultado do TratamentoRESUMO
Autonomic dysfunction has rarely been studied in patients suffering from multiple sclerosis (MS). Some hypotheses have concerned the pathophysiology, especially with regard to a possible spinal cord origin. However, there have been no previous studies on autonomic dysfunction in MS and spinal cord lesions. This study assessed the frequency of autonomic dysfunction (AD) in MS and the correlation to spinal cord magnetic resonance imaging (MRI) findings. We prospectively studied 75 MS patients (25 with relapsing-remitting forms, 25 with secondary progressive forms and 25 with primary progressive forms). We performed sympathetic skin response, R-R interval variability and orthostatic hypotension testing. Spinal cord MRI was performed to detect demyelinating lesions (sagittal and axial plane) or spinal cord atrophy. Clinical and laboratory evidence of AD was found in 84% and 56% of MS patients, respectively. The correlation of the latter with disability was evaluated using the Extended Disability Status Scale. AD was more frequent in primary progressive MS than in the other two forms. AD was correlated with spinal cord cross-sectional area reduction but not with spinal cord hyperintensities. This study confirms that the frequency of AD in MS, especially in primary progressive forms, has until now been underestimated. Furthermore, AD appears to be more closely related to axonal loss, as demonstrated by spinal cord atrophy, than to demyelinating lesions.
Assuntos
Doenças do Sistema Nervoso Autônomo/etiologia , Esclerose Múltipla/complicações , Esclerose Múltipla/patologia , Medula Espinal/patologia , Adulto , Atrofia , Doenças do Sistema Nervoso Autônomo/patologia , Axônios/patologia , Progressão da Doença , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Estudos ProspectivosRESUMO
OBJECTIVE: This study aimed to investigate changes in spatio-temporal, event-related (de)synchronization (ERD/ERS) patterns recorded with respect to the more akinetic versus the less akinetic side during performance of a visuo-guided targeting movement when compared to an index finger extension. METHODS: Twelve de novo parkinsonian patients were recorded. ERD/ERS in mu and beta frequency bands was computed from 21 source derivations. RESULTS: When the index finger extension was performed with the less akinetic limb, mu ERD focused over contralateral central region appeared 2 s before movement. With the targeting movement, additional pre-movement mu ERD was observed over the parietal region, as well as earlier ipsilateral mu ERD. When the same movements were performed with the more akinetic limb, we observed delayed mu ERD over contralateral regions, earlier ipsilateral mu ERD and a lack of contralateral parietal mu ERD before the targeting movement. Following index finger extension for the less akinetic limb, a focused contralateral central beta ERS was recorded, increasing and spreading after the targeting movement. In contrast, for the more akinetic limb, beta ERS was dramatically attenuated and remained unchanged after the targeting movement. CONCLUSIONS: These results confirm the fact that motor programming is delayed, and provide some insight into what may well be impaired sensorimotor integration in Parkinson's disease.
Assuntos
Neurônios Motores/fisiologia , Neurônios Aferentes/fisiologia , Doença de Parkinson/fisiopatologia , Desempenho Psicomotor/fisiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Sincronização Cortical , Discinesias/fisiopatologia , Eletromiografia , Feminino , Dedos , Lateralidade Funcional , Humanos , Masculino , Pessoa de Meia-Idade , Movimento , VoliçãoRESUMO
OBJECTIVES: Indications of the functional neurosurgical treatments become more and more numerous, however, few methods were used to study the mechanism of action and some discrepancies came to light. We assessed the influence of internal globus pallidus (GPI) stimulation and L-Dopa on cortical activation during the preparation and execution phases of the movement compared to clinical improvement of Parkinson's disease. METHODS: We recorded the movement-related cortical potential and movement-related desynchronization. RESULTS: The Unified Parkinson's Disease Rating Scale was improved by 46% under stimulation and 64% under stimulation with L-Dopa. Premovement desynchronization was significantly increased on central contralateral derivation under stimulation with L-Dopa and decreased on frontocentral ipsilateral derivation under stimulation with and without L-Dopa. Movement desynchronization was improved on the contralateral motor cortex under stimulation with and without L-Dopa (benefit correlated with bradykinesia improvement). The movement-related postmotor potential was significantly increased under stimulation with L-Dopa. CONCLUSIONS: GPI stimulation alone influenced the premotor cortex activation during the planning and induced a selective and focal effect on the organisation of motor cortical activity during the movement execution which may explain bradykinesia improvement. The motor cortex activation improvement under stimulation with L-Dopa concerned both the movement preparation and execution but remained very localised to the contralateral motor cortex.
Assuntos
Globo Pálido/fisiopatologia , Córtex Motor/fisiopatologia , Doença de Parkinson/fisiopatologia , Idoso , Antiparkinsonianos/uso terapêutico , Sincronização Cortical , Estimulação Elétrica , Eletrodos Implantados , Eletroencefalografia/efeitos dos fármacos , Feminino , Humanos , Levodopa/uso terapêutico , Masculino , Pessoa de Meia-Idade , Movimento/fisiologia , Músculo Esquelético/inervação , Músculo Esquelético/fisiologia , Doença de Parkinson/tratamento farmacológicoRESUMO
OBJECTIVE: In order to better understand the spatio-temporal interaction of the activated cortical areas when the movement is visuo-guided and to assess the age effect on the spatio-temporal pattern of cortical activity, we have compared a proximo-distal movement with visual-motor control and hand-eye coordination (targeting movement) with a distal and a proximal movement. METHODS: Brain's electrical activity was studied using the analysis of event-related (de)synchronizations (ERD/S) of cortical mu and beta rhythms in 17 subjects, 8 young and 9 elderly subjects. RESULTS: In both populations, we found an earlier and broader mu and beta ERD during the preparation of the targeting movement compared to distal and proximal movements, principally involving the contralateral parietal region. During the execution, a spreading over the parietocentral region during proximal movement and over the parietal region during targeting movement was observed. After the execution of proximal and targeting movements, a wider and higher beta ERS was observed only in the young subjects. In the elderly subjects, our results showed a significant decrease of beta ERS during the targeting task. CONCLUSIONS: These results suggest there was a larger recruitment of cortical areas, involving notably the parietal cortex when the movement is visuo-guided. Moreover, cerebral aging-related changes in the spatio-temporal beta ERS pattern suggests an impaired sensory integration.
Assuntos
Envelhecimento/fisiologia , Córtex Cerebral/fisiologia , Potenciais Evocados/fisiologia , Desempenho Psicomotor/fisiologia , Adulto , Idoso , Braço/fisiologia , Mapeamento Encefálico , Eletroencefalografia , Eletromiografia , Feminino , Dedos/fisiologia , Lateralidade Funcional/fisiologia , Humanos , Masculino , Pessoa de Meia-Idade , Movimento/fisiologia , Estimulação Luminosa , Tempo de Reação/fisiologia , Ombro , Fatores de TempoRESUMO
OBJECTIVE: Studies of the effects on lower-limb cortical somatosensory evoked potentials (CSEP) during total intravenous anesthesia are sparse for propofol and are lacking for midazolam. This study was designed to compare the effects of propofol and midazolam on CSEP under total intravenous anesthesia during intraoperative monitoring for surgical treatment of scoliosis. METHODS: CSEPs were recorded in two groups of 15 patients during posterior instrumentation for treatment of idiopathic scoliosis. The anesthesia used the combination of atracurium, alfentanil, and an hypnotic agent (propofol for Group I or midazolam for Group II). The main characteristics of the CSEPs (P40 latency and N34-P40 and P40-N50 amplitudes) were recorded using ankle posterior tibial nerve stimulation. The CSEPs were recorded before induction, 10, 70, 100, 130, and 160 minutes after induction, and before the wake-up test. The statistical analysis involved analysis of variance for repeated measures. Both groups were homogeneous before induction. RESULTS: Neither CSEP deterioration during risk-associated surgical procedures nor postoperative clinical abnormalities were observed. Both propofol and midazolam induced increases in P40 latencies, with the increases being greater and more regular for the propofol-treated group. The amplitude values changed with time for both groups, decreasing mainly after induction; in the midazolam-treated group, the amplitudes were smaller but more stable. Propofol modified the morphological characteristics of the response by decreasing the late P60 component amplitude; the W-shaped CSEP morphological pattern was maintained with midazolam. CONCLUSION: This study demonstrates the appropriate use of either propofol or midazolam in scoliosis monitoring. Preoperative small-amplitude CSEPs might favor the use of propofol anesthesia.
Assuntos
Anestesia Intravenosa , Anestésicos Intravenosos , Potenciais Somatossensoriais Evocados/efeitos dos fármacos , Midazolam , Monitorização Intraoperatória , Propofol , Escoliose/cirurgia , Adolescente , Adulto , Estimulação Elétrica , Potenciais Somatossensoriais Evocados/fisiologia , Feminino , Humanos , Masculino , Tempo de Reação/efeitos dos fármacos , Escoliose/fisiopatologia , Córtex Somatossensorial/efeitos dos fármacos , Córtex Somatossensorial/fisiopatologiaRESUMO
The authors report on the long-term results of chronic stereotactic stimulation of the ventralis intermedius thalamic nucleus performed in 14 cases of disabling and intractable tremor. There were 10 patients with parkinsonian tremor and four with essential tremor. Three of the 10 parkinsonian patients had previously undergone contralateral thalamotomy. Tremor was assessed by clinical evaluation, surface electromyography, accelerometer, and videotape recordings before and after stimulation. The deep-brain electrode was implanted in the ventralis intermedius nucleus according to stereotactic procedure and connected to a subcutaneous pulse generator after a stimulation test period. Tremor suppression or reduction was obtained in all cases with high-frequency (130 Hz) stimulation. Marked functional improvement was maintained in 11 patients with a mean follow-up interval of 17 months. Levodopa-induced dyskinesias observed in five parkinsonian patients prior to surgery were improved or suppressed in four cases by thalamic stimulation. Stimulation was continued during the day and stopped at night in eight cases. Six patients were stimulated night and day to avoid a rebound effect which appeared as soon as the pulse generator was stopped. The only side effects were hand tonic posture in one case and persistent paresthesia in another case. The mechanism of action of this attractive treatment may be a functional alteration of the thalamic discharging area. The authors conclude that this technique is a good alternative to thalamotomy, especially when the risks of high-frequency coagulation are severe in frail and older patients.
Assuntos
Terapia por Estimulação Elétrica/métodos , Técnicas Estereotáxicas , Núcleos Talâmicos/fisiopatologia , Tremor/terapia , Adulto , Idoso , Terapia por Estimulação Elétrica/efeitos adversos , Humanos , Pessoa de Meia-Idade , Núcleos Talâmicos/cirurgia , Tremor/etiologia , Tremor/cirurgiaRESUMO
To explore changes in melatonin secretion patterns and biologic rhythms in Parkinson's disease patients with or without levodopa-related motor complications (LDRMCs), the authors investigated, in an observational study, circadian rhythms of central temperature, motor activity, plasma cortisol, and melatonin in three groups: de novo untreated patients (group I), patients treated with levodopa + dopamine agonist and without LDRMCs (group II), and patients treated with levodopa + dopamine agonist and with LDRMCs (group III). There were no differences among the three groups for the rhythm of temperature, motor activity, or plasma cortisol. There was a significant (p < 0.05) phase advance in plasma melatonin secretion in patients receiving a dopaminergic treatment compared with untreated patients. The daytime area under the curve (AUC) was increased significantly in group III, and the nighttime AUC-to-daytime AUC ratio of melatonin secretion decreased significantly in group III, suggesting that the nychthemeral pattern of melatonin secretion was changed in patients with LDRMCs. Comparison of the three groups suggests a slight but insignificant phase advance and amplitude decrease of circadian melatonin secretion related to both evolution and treatment of Parkinson's disease. Despite the lack of a global desynchronization in other circadian biologic rhythms, the circadian secretion pattern of melatonin is modified in patients with LDRMCs.
Assuntos
Ritmo Circadiano , Melatonina/metabolismo , Doença de Parkinson/sangue , Idoso , Área Sob a Curva , Ritmo Circadiano/fisiologia , Feminino , Humanos , Hidrocortisona/sangue , Masculino , Melatonina/sangue , Pessoa de Meia-Idade , Doença de Parkinson/fisiopatologia , Estatísticas não ParamétricasRESUMO
Although frequently investigated in the general population, the epidemiology of insomnia complaints and their treatment have received little attention in general practice. This study recruited patients > or =15 years of age, consecutively, from 127 general practitioners in France. The physicians collected data from 11,810 of their patients, of whom 55.5% were women. Insomnia complaints were reported by 26.2% (25.4% to 27%) of the sample and use of sleep-promoting medication by 10.1% (9.7% to 10.7%). About 47% of the prescribed drugs used were anxiolytics and 45% hypnotics. Most consumers took sleep-enhancing drugs on a daily and long-term basis and most reported that the medication improved their quality of sleep. However, few distinctions emerged between elderly drug-taking insomniacs and elderly nontreated insomniacs with respect to the various dimensions of sleep. Results underscore the persistent general tendency among French general practitioners to overprescribe anxiolytics for the treatment of insomnia complaints and that they do so on a long-term basis, despite the findings of numerous studies showing that benzodiazepines are ineffective in the treatment of sleep complaints over the long term.
Assuntos
Ansiolíticos/uso terapêutico , Medicina de Família e Comunidade/estatística & dados numéricos , Hipnóticos e Sedativos/uso terapêutico , Padrões de Prática Médica , Distúrbios do Início e da Manutenção do Sono/tratamento farmacológico , Adolescente , Adulto , Distribuição por Idade , Idoso , Estudos de Casos e Controles , Revisão de Uso de Medicamentos , Feminino , França/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade , Vigilância da População , Prevalência , Psicotrópicos/uso terapêutico , Distribuição por Sexo , Distúrbios do Início e da Manutenção do Sono/epidemiologia , Distúrbios do Início e da Manutenção do Sono/psicologiaRESUMO
Event-related desynchronization (ERD) was studied in 10 young (mean age = 19.1) and 10 older (mean age = 62.8) subjects during a verbal recognition task. The attention load of the task varied according to the difficulty of discriminating between targets and distractors. EEG recorded from 29 electrodes was used to compute ERD from 14 source derivations in 125 ms intervals. Thereafter, it was displayed as spatiotemporal maps. The results show that attention influences the characteristics of EEG desynchronization. In young subjects, ERD is more pronounced and more widespread when the attentional load is high. In the elderly, differences between the two attention conditions are less marked. ANOVA reveals main effects of attention and time. The significant 'attention x time x age group' interaction confirms the presence of different brain activation patterns in the two age groups in relation to attention load.
Assuntos
Envelhecimento/fisiologia , Sincronização Cortical , Memória/fisiologia , Adolescente , Adulto , Idoso , Atenção/fisiologia , Mapeamento Encefálico , Cognição/fisiologia , Sinais (Psicologia) , Eletroencefalografia , Feminino , Humanos , Masculino , Rememoração Mental/fisiologia , Pessoa de Meia-Idade , Desempenho Psicomotor/fisiologia , Aprendizagem Verbal/fisiologiaRESUMO
The effects of age, stimulus modality and event probability on event-related potentials (ERP) were studied in 12 young and 12 elderly healthy subjects. The ERP were recorded from 15 electrodes referred to linked ears. Results showed that both amplitude and latency of the P300 component are affected by aging. Study of the latency of the earlier ERP components in the two age groups revealed that the P300 delay was not imputable to a delay of the earlier components. P300 amplitude and latency were also affected by event probability and stimulus modality: infrequent stimulus involved higher and later P300, but this effect was more pronounced in the young than in the old group; higher and later P300 were also recorded during the visual task compared to the auditory. Topographical repartition of the brain wave revealed a predominance of the central sites (Fz, Cz, Pz). The findings are discussed in relation to the sensitivity of the ERP assessment procedures in age related modifications of information processing.
Assuntos
Envelhecimento/fisiologia , Atenção/fisiologia , Potenciais Evocados Auditivos/fisiologia , Potenciais Evocados Visuais/fisiologia , Estimulação Acústica , Adolescente , Adulto , Idoso , Eletroencefalografia , Eletroculografia , Feminino , Humanos , Masculino , Processos Mentais/fisiologia , Pessoa de Meia-Idade , Estimulação Luminosa , Tempo de Reação/fisiologiaRESUMO
The interest of the event-related desynchronization study has already been evidenced, for example in the study of the cerebral activation modifications consecutive to cognitive processes. We observed here the evolution of this index during a recognition task where the material to memorize varied. Ten young subjects had to learn and then recognize a list of words or forms. The desynchronization of the alpha rhythm consecutive to each stimulus was recorded at 14 localizations on the scalp. We observed that the time evolution of the event-related desynchronization was different in each task. In the visual task, the phenomenon began sooner and was longer lasting. As long as the cortical area were concerned, any dominance nor interhemispheric difference were observed. During the visuospatial recognition task, the event-related desynchronization was however more widespread.
Assuntos
Mapeamento Encefálico , Encéfalo/fisiologia , Cognição/fisiologia , Sincronização Cortical , Memória/fisiologia , Adolescente , Adulto , Eletroencefalografia , Feminino , Humanos , Masculino , Testes Psicológicos , Análise e Desempenho de TarefasRESUMO
Two kinds of methods are available in order to assess the functional relationships between different cerebral structures from the analysis of EEG signals: linear and non-linear methods. In this paper, we describe didactically the methodological bases of signal processing. After recalling the significance of the fundamental parameters of a sine wave: frequency, amplitude and phase, we show, from a first example about an epileptic seizure propagation, how a linear variation between phase and frequency can be interpreted as a small time difference between two EEG channels. This linear method hypothesises that these two signals are respectively the input and the output of a linear system. Then, we point out the limits of this method and we introduce non-linear methods. Among the latter, a recent approach introduces a realistic model of EEG which try to relate signal measured quantities to relations between underlying structures which produce them.
Assuntos
Encéfalo/fisiologia , Eletroencefalografia/estatística & dados numéricos , Dinâmica não Linear , Processamento de Sinais Assistido por Computador , Algoritmos , Epilepsia/fisiopatologia , Humanos , Modelos LinearesRESUMO
The authors report the main effects of anaesthetic drugs that are used alone or in association with anaesthetic protocols on somatosensory evoked potentials (SEP) and on motor evoked potentials (MEP). In the first part of the article, the effects are analysed on SEPs and MEPs that are obtained from non-invasive methods; in the second part, the effects of anaesthesia are analysed with respect to invasive methods of EP recordings. The current increase of invasive techniques of neuromonitoring by SEPs and MEPs is in relation with the weak effect of anaesthetics on evoked responses. Total intravenous anaesthesia (TIVA) provides stable anaesthesia for non-invasive SEP neuromonitoring only if bolus is avoided. With TIVA and other anaesthetic techniques, the introduction of repetitive stimulation provides new possibilities for non-invasive MEP neuromonitoring.
Assuntos
Anestesia/métodos , Anestésicos/farmacologia , Potencial Evocado Motor/efeitos dos fármacos , Potenciais Somatossensoriais Evocados/efeitos dos fármacos , Monitorização Intraoperatória/métodos , Coluna Vertebral/cirurgia , Analgésicos Opioides/farmacologia , Anestésicos Inalatórios/farmacologia , Humanos , Hipnóticos e Sedativos/farmacologia , Bloqueadores Neuromusculares/farmacologia , Medula Espinal/efeitos dos fármacos , Medula Espinal/fisiologiaRESUMO
The desynchronization of Alpha band components during a self-paced movement of the thumb was studied in 7 subjects. The EEG was recorded from 23 electrodes located on the frontocentral, central, and parietocentral regions, referred to the right mastoïde, 4 s before and 2 s after movement onset. The data were then transformed to obtain 11 source derivations. The temporal evolution of the power of the signal within the Alpha band, every 250 ms, associated to the non parametric statistic test of Wilcoxon, authentifies the event-related desynchronization (ERD). The spatiotemporal analysis of ERD underlines on the central regions, two principal locations of ERD: one controlateral to the movement, starting more than 1 s before the movement; the other, ipsilateral, shorter, during the movement. However, no significance desynchronization was underlined on the vertex. The ANOVA used to analyse these results confirms the principal location of ERD on the central region, and seems to indicate a right lateralisation during the right or the left movement.
Assuntos
Sincronização Cortical , Movimento/fisiologia , Adulto , Análise de Variância , Encéfalo/fisiologia , Variação Contingente Negativa/fisiologia , Eletroencefalografia , Feminino , Lateralidade Funcional , Humanos , Masculino , Polegar/fisiologiaRESUMO
Laser somatosensory evoked potentials (LSEP) evaluate the functional integrity of thermoalgic pathways by the specific stimulation of A delta and C nociceptive afferences. As compared to a CO2 laser, the thulium Yttrium Aluminium Garnet (YAG) laser may be conducted by an optic fiber, which allows easier access to the stimulated body sites. We present normative data on thulium YAG LSEPs recorded after stimulation of upper and lower limbs (N = 15). LSEPs were obtained with a stimulation intensity that was twice the nociceptive threshold at the upper limbs (UL) and one and a half at the lower limbs (LL). To ensure a stable attentional level, subjects were asked to estimate stimulus intensity after each stimulation. The nociceptive thresholds at upper and lower limbs were respectively 319 +/- 65 mJ and 359 +/- 95, and with the above methodology the LSEPs could be obtained in every subject. The latencies of N2 and P2 were respectively 199 +/- 18 ms and 325 +/- 37 ms at the UL, 239 +/- 36 ms and 378 +/- 38 ms at the LL. This method produced robust and reproducible results and proved to be reliable for routine clinical use. To optimise response stability we propose that right/left stimulation be conducted following an 'A-B-B-A' procedure.