Detalhe da pesquisa
1.
The antidepressant tianeptine reverts synaptic AMPA receptor defects caused by deficiency of CDKL5.
Hum Mol Genet
; 27(12): 2052-2063, 2018 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29618004
2.
Understanding and predicting disease relationships through similarity fusion.
Bioinformatics
; 35(7): 1213-1220, 2019 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30169824
3.
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.
Proc Natl Acad Sci U S A
; 112(16): E1994-2003, 2015 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25855634
4.
Nanobodies raised against monomeric É-synuclein inhibit fibril formation and destabilize toxic oligomeric species.
BMC Biol
; 15(1): 57, 2017 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28673288
5.
Structural Effects of Two Camelid Nanobodies Directed to Distinct C-Terminal Epitopes on α-Synuclein.
Biochemistry
; 55(22): 3116-22, 2016 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27096466
6.
α-Synuclein senses lipid packing defects and induces lateral expansion of lipids leading to membrane remodeling.
J Biol Chem
; 288(29): 20883-20895, 2013 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23740253
7.
A novel combination treatment for fragile X syndrome predicted using computational methods.
Brain Commun
; 6(1): fcad353, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38226317
8.
Repurposing available drugs for neurodevelopmental disorders: The fragile X experience.
Neuropharmacology
; 147: 74-86, 2019 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29792283
9.
The use or generation of biomedical data and existing medicines to discover and establish new treatments for patients with rare diseases - recommendations of the IRDiRC Data Mining and Repurposing Task Force.
Orphanet J Rare Dis
; 14(1): 225, 2019 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31615551
10.
Drug repurposing: progress, challenges and recommendations.
Nat Rev Drug Discov
; 18(1): 41-58, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30310233
11.
Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding.
Protein Sci
; 27(7): 1262-1274, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29603451
12.
Identifying the science and technology dimensions of emerging public policy issues through horizon scanning.
PLoS One
; 9(5): e96480, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24879444
13.
Preconditioning of microglia by α-synuclein strongly affects the response induced by toll-like receptor (TLR) stimulation.
PLoS One
; 8(11): e79160, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24236103
14.
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages.
J Mol Biol
; 425(14): 2397-411, 2013 Jul 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-23557833
15.
Structure and properties of a complex of α-synuclein and a single-domain camelid antibody.
J Mol Biol
; 402(2): 326-43, 2010 Sep 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-20620148