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1.
J Allergy Clin Immunol ; 130(6): 1344-54, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-22951056

RESUMO

BACKGROUND: Atopic dermatitis (AD) is a common disease with an increasing prevalence. The primary pathogenesis of the disease is still elusive, resulting in the lack of specific treatments. AD is currently considered a biphasic disease, with T(H)2 predominating in acute disease and a switch to T(H)1 characterizing chronic disease. Elucidation of the molecular factors that participate in the onset of new lesions and maintenance of chronic disease is critical for the development of targeted therapeutics. OBJECTIVES: We sought to characterize the mechanisms underlying the onset and maintenance of AD. METHODS: We investigated intrapersonal sets of transcriptomes from nonlesional skin and acute and chronic lesions of 10 patients with AD through genomic, molecular, and cellular profiling. RESULTS: Our study associated the onset of acute lesions with a striking increase in a subset of terminal differentiation proteins, specifically the cytokine-modulated S100A7, S100A8, and S100A9. Acute disease was also associated with significant increases in gene expression levels of major T(H)22 and T(H)2 cytokines and smaller increases in IL-17 levels. A lesser induction of T(H)1-associated genes was detected in acute disease, although some were significantly upregulated in chronic disease. Further significant intensification of major T(H)22 and T(H)2 cytokines was observed between acute and chronic lesions. CONCLUSIONS: Our data identified increased S100A7, S100A8, and S100A9 gene expression with AD initiation and concomitant activation of T(H)2 and T(H)22 cytokines. Our findings support a model of progressive activation of T(H)2 and T(H)22 immune axes from the acute to chronic phases, expanding the prevailing view of pathogenesis with important therapeutic implications.


Assuntos
Dermatite Atópica/imunologia , Interleucinas/imunologia , Pele/imunologia , Células Th17/imunologia , Células Th2/imunologia , Doença Aguda , Adulto , Idoso , Calgranulina A/genética , Calgranulina A/metabolismo , Calgranulina B/genética , Calgranulina B/metabolismo , Doença Crônica , Feminino , Humanos , Interleucina-17/imunologia , Masculino , Pessoa de Meia-Idade , Proteína A7 Ligante de Cálcio S100 , Proteínas S100/genética , Proteínas S100/metabolismo , Equilíbrio Th1-Th2 , Regulação para Cima , Adulto Jovem , Interleucina 22
2.
Virtual Mentor ; 13(6): 333-5, 2011 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-23131398
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