RESUMO
The title compound, C(17)H(12)BrClN(2)O, was synthesized by oxidation of [3-(4-bromo-phen-yl)-1-(4-chloro-benz-yl)-1H-pyrazol-5-yl]methanol under mild conditions. The pyrazole ring makes dihedral angles of 3.29â (9) and 74.91â (4)°, respectively, with the bromo-phenyl and chloro-phenyl rings.
RESUMO
In the title compound, C(20)H(20)N(2)O(2), the pyrazole ring makes dihedral angles of 15.68â (4) and 83.40â (4)°, respectively, with the tolyl and benzyl rings, respectively.
RESUMO
The title compound, C(21)H(33)NO, crystallizes with three independent mol-ecules in the asymmetric unit. The cyclo-hexane and piperidine rings adopt chair conformations. The crystal packing is stabilized by inter-molecular O-Hâ¯N and C-Hâ¯O hydrogen bonds, and by weak π-π stacking inter-actions [centroid-centroid distance = 3.876â (2)â Å].
RESUMO
Griffonia simplicifolia lectin II (GSII) and wheat germ agglutinin (WGA) are N-acetylglucosamine-binding lectins. Previous studies demonstrated that they have anti-insect activity, a property potentially useful in pest control. To gain some insight into the insect response to dietary lectins, we performed transcriptomic analysis using the cowpea bruchid (Callosobruchus maculatus) midgut microarray platform we built. Compared to the nonnutritional cellulose treatment, dietary lectins induced more profound changes in gene expression. Ingestion of relatively high doses of lectins for 24 h resulted in alteration of gene expression involved in sugar and lipid metabolism, transport, development, defense, and stress tolerance. Metabolic genes were largely downregulated. Moreover, we observed disorganized microvilli resulting from ingestion of WGA. This morphological change is consistent with the lectin-induced changes in genes related to midgut epithelial cell repair. In addition, suboptimal nutrient conditions may serve as a stress signal to trigger senescence processes, leading to growth arrest and developmental delay.