1.
J Nat Prod
; 80(7): 2118-2123, 2017 07 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28699746
RESUMO
The full absolute configuration assignment of phosphoeleganin (1), a recently discovered marine-derived phosphorylated polyketide with protein tyrosine phosphatase 1B inhibitory activity, was achieved. It was based on the synthesis of model diasteroisomeric compounds of the C-8-C-12 segment portion of phosphoeleganin, chiral derivatization methods, and application of the universal NMR database concept.
Assuntos
Policetídeos/química , Proteína Tirosina Fosfatase não Receptora Tipo 1/antagonistas & inibidores , Bases de Dados Factuais , Biologia Marinha , Modelos Químicos , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Policetídeos/síntese química , Policetídeos/farmacologia , Estereoisomerismo
2.
J Nat Prod
; 79(4): 1144-8, 2016 Apr 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27064611
RESUMO
A new phosphorylated polyketide, phosphoeleganin (1), has been isolated from the Mediterranean ascidian Sidnyum elegans. Its structure and configuration have been determined by extensive use of 2D NMR and microscale chemical degradation and/or derivatization. Phosphoeleganin (1) inhibited the protein tyrosine phosphatase 1B (PTP1B) activity.