1.
J Assoc Physicians India
; 50: 907-9, 2002 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12126345
RESUMO
Four patients of rheumatoid arthritis (RA) with biopsy confirmed AA amyloidosis were treated with chlorambucil. All had established but uncontrolled RA with a persistently raised ESR. Moderate (> 1 gm, < 3.5 gm/d) to nephrotic range (> 3.5 gm/d) proteinuria and a relatively well preserved renal function was noted in three patients. One patient had deranged renal function and required dialysis. On chlorambucil, there was complete recovery, partial improvement and no improvement in one patient each. The fourth patient required haemodialysis, did not tolerate chlorambucil and succumbed to the illness. Therapy with chlorambucil can benefit some patients of RA with AA amyloidosis. Leucopenia is the most important dose limiting side effect.
Assuntos
Amiloidose/tratamento farmacológico , Antineoplásicos Alquilantes/uso terapêutico , Artrite Reumatoide/tratamento farmacológico , Clorambucila/uso terapêutico , Adulto , Feminino , Humanos , Pessoa de Meia-Idade
2.
J Assoc Physicians India
; 49: 1120-2, 2001 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11868872