RESUMO
During the mass measles/rubella vaccination campaign in 2003 in Iran, many pregnant women were vaccinated mistakenly or became pregnant within 1 month of vaccination. To distinguish pregnant women who were affected by rubella vaccine as primary infection from those who had rubella reinfection from the vaccine, serum samples were collected 1-3 months after the campaign from 812 pregnant women. IgG avidity assay showed that 0.3% of the women had no rubella-specific IgG response; 14.4% had low-avidity anti-rubella IgG and were therefore not immune to rubella before vaccination; 85.3% had high-avidity anti-rubella IgG and were regarded as cases of reinfection.
Assuntos
Anticorpos Antivirais/imunologia , Técnicas Imunoenzimáticas/métodos , Imunoglobulina G/imunologia , Complicações Infecciosas na Gravidez/epidemiologia , Vacina contra Rubéola/efeitos adversos , Vírus da Rubéola/imunologia , Rubéola (Sarampo Alemão)/epidemiologia , Adolescente , Adulto , Anticorpos Antivirais/sangue , Afinidade de Anticorpos/imunologia , Distribuição de Qui-Quadrado , Feminino , Humanos , Técnicas Imunoenzimáticas/normas , Imunoglobulina G/sangue , Irã (Geográfico)/epidemiologia , Vacinação em Massa/efeitos adversos , Vacinação em Massa/métodos , Erros Médicos/estatística & dados numéricos , Valor Preditivo dos Testes , Gravidez , Complicações Infecciosas na Gravidez/sangue , Complicações Infecciosas na Gravidez/imunologia , Complicações Infecciosas na Gravidez/virologia , Rubéola (Sarampo Alemão)/sangue , Rubéola (Sarampo Alemão)/imunologia , Rubéola (Sarampo Alemão)/virologia , Vacina contra Rubéola/imunologia , Estudos Soroepidemiológicos , Estatísticas não ParamétricasRESUMO
During the mass measles/rubella vaccination campaign in 2003 in Iran, many pregnant women were vaccinated mistakenly or became pregnant within 1 month of vaccination. To distinguish pregnant women who were affected by rubella vaccine as primary infection from those who had rubella reinfection from the vaccine, serum samples were collected 1-3 months after the campaign from 812 pregnant women. IgG avidity assay showed that 0.3% of the women had no rubella-specific IgG response; 14.4% had low-avidity anti-rubella IgG and were therefore not immune to rubella before vaccination; 85.3% had high-avidity antirubella IgG and were regarded as cases of reinfection