RESUMO
A new lanthanide coordination polymer, [Eu(2-stp) (2,2'-bipy) (H2O)] · H2O (2-stp = 2-sufoterephthalalic acid, 2, 2'-bipy=2,2'-bipyridine) was obtained by hydrothermal method. The crystal structure was determined by single crystal X-ray diffraction. The complex has a one-dimensional parallel double-chain structure. Eu³âº is a nine-coordinated by six O atoms from three 2-sufoterephthalalic acids, one water molecule and two N atoms from 2,2'-bipyridine. The fluorescence properties of the complex were studied. The complex shows the characteristics narrow emission of ion at 581, 594, 619, 654 and 698 nm, corresponding to 5D0-->Fj (J = 0-4) transitions. The strongest emission peak is at 619 nm, corresponding to 5D0-F2 transition for red light. Different organic solvents have different effects on the fluorescence intensity of the complex, and enzaldehyde exerts the most significant fluorescence quenching effect. So, this complex can be used as a fluorescent sensing probe for benzaldehyde.
RESUMO
CONTEXT: The excision repair cross-complementation group 1 (ERCC1) codon 118 C/T polymorphism has been associated with clinical outcome in cancer patients treated with platinum chemotherapy. Ethnic differences in the frequency of this polymorphism have been observed in Caucasian and African populations. AIM: The aim of this study was to evaluate the frequency and survival benefit of the ERCC1 codon 118 C/T polymorphism in a high-altitude population with advanced gastric cancer. MATERIALS AND METHODS: Polymerase chain reaction-restriction fragment length polymorphism was used to determine the frequency of ERCC1 118 codon C/T polymorphism in 206 advanced gastric cancer patients residing in the high-altitude Qinghai-Tibetan plateau. The influence of the ERCC1 codon 118 C/T polymorphism on its micro ribonucleic acid (mRNA) and protein expression, clinicopathological features; response to the platinum-based combination chemotherapy, and the outcome was evaluated. STATISTICAL ANALYSIS: The Kaplan-Meier method was used for survival analysis. The correlation of ERCC1 codon 118 polymorphism with ERCC1 mRNA and protein expression, clinicopathological characteristics, and first-line oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX-4) response was determined by χ(2)-test. RESULTS AND CONCLUSIONS: ERCC1 codon 118 C/T polymorphism was not associated with ERCC1 mRNA and protein expression, FOLFOX-4 response, and progression-free survival (PFS) or overall survival (OS). High ERCC1 mRNA and protein expression levels were associated with significantly lower FOLFOX-4 responses, PFS, and OS. ERCC1 codon 118 C/T polymorphism is not an important prognostic marker for advanced gastric cancer. Determination of ERCC1 mRNA and protein levels may be beneficial in predicting the response and outcome of FOLFOX-4 therapy in gastric cancer.