RESUMO
A reply to the correspondence by Deora et al.- Critical insights on "Association of the C allele of rs479200 in the EGLN1 gene with COVID19 severity in Indian population: a novel finding". The reply contains point-wise rebuttal to the concerns, particularly addressing the epidemiological, statistical, and mathematical issues raised by Deora et al.
Assuntos
Alelos , COVID-19 , Prolina Dioxigenases do Fator Induzível por Hipóxia , SARS-CoV-2 , Humanos , COVID-19/genética , COVID-19/epidemiologia , COVID-19/virologia , Índia/epidemiologia , SARS-CoV-2/genética , SARS-CoV-2/patogenicidade , Prolina Dioxigenases do Fator Induzível por Hipóxia/genética , Polimorfismo de Nucleotídeo Único/genética , Índice de Gravidade de Doença , Predisposição Genética para DoençaRESUMO
The present study investigated two single nucleotide polymorphisms (SNPs)-rs479200 and rs516651 in the host EGLN1/PHD2 gene for their association with COVID-19 severity. A retrospective cohort of 158 COVID-19 patients from the Indian population (March 2020 to June 2021) was enrolled. Notably, the frequency of C allele (0.664) was twofold higher than T allele (0.336) in severe COVID-19 patients. Here, we report a novel finding that the C allele of rs479200 in the EGLN1 gene imparts a high risk of severe COVID-19 (odds ratio-6.214 (1.84-20.99) p = 0.003; 9.421 (2.019-43.957) p = 0.004), in additive inheritance model (adjusted and unadjusted, respectively).