Detalhe da pesquisa
1.
Functional CRISPR and shRNA Screens Identify Involvement of Mitochondrial Electron Transport in the Activation of Evofosfamide.
Mol Pharmacol
; 95(6): 638-651, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30979813
2.
Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition.
BMC Cancer
; 15: 422, 2015 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25994202
3.
Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features.
Blood
; 119(24): 5782-94, 2012 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22394600
4.
Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug.
Blood
; 116(9): 1524-7, 2010 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-20530289
5.
Retraction: Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1α inhibition, and hypoxia-activated chemotherapy.
Oncotarget
; 15: 123, 2024 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38329733
6.
Correction: Selective Tumor Hypoxia Targeting by Hypoxia-Activated Prodrug TH-302 Inhibits Tumor Growth in Preclinical Models of Cancer.
Clin Cancer Res
; 30(10): 2287, 2024 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38745478
7.
Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs.
J Med Chem
; 51(8): 2412-20, 2008 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-18257544
8.
A novel class of tubulin inhibitors that exhibit potent antiproliferation and in vitro vessel-disrupting activity.
Cancer Chemother Pharmacol
; 61(6): 953-63, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-17639393
9.
Radiotherapy Synergizes with the Hypoxia-Activated Prodrug Evofosfamide: In Vitro and In Vivo Studies.
Antioxid Redox Signal
; 28(2): 131-140, 2018 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28741367
10.
Hypoxia-activated evofosfamide for treatment of recurrent bevacizumab-refractory glioblastoma: a phase I surgical study.
Neuro Oncol
; 20(9): 1231-1239, 2018 08 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29415215
11.
Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice.
Cancer Res
; 78(14): 3783-3792, 2018 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29792309
12.
Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma.
JCI Insight
; 3(16)2018 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30135316
13.
Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma.
JCI Insight
; 8(4)2023 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36810255
14.
A Combination of Radiation and the Hypoxia-Activated Prodrug Evofosfamide (TH-302) is Efficacious against a Human Orthotopic Pancreatic Tumor Model.
Transl Oncol
; 10(5): 760-765, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28778024
15.
Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer.
Clin Cancer Res
; 23(2): 536-548, 2017 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27440271
16.
Hypoxia Imaging With PET Correlates With Antitumor Activity of the Hypoxia-Activated Prodrug Evofosfamide (TH-302) in Rodent Glioma Models.
Tomography
; 2(3): 229-237, 2016 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-27752544
17.
Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1α inhibition, and hypoxia-activated chemotherapy.
Oncotarget
; 7(28): 42844-42858, 2016 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27374091
18.
Comparison of hypoxia-activated prodrug evofosfamide (TH-302) and ifosfamide in preclinical non-small cell lung cancer models.
Cancer Biol Ther
; 17(4): 371-80, 2016 04 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26818215
19.
MR Imaging Biomarkers to Monitor Early Response to Hypoxia-Activated Prodrug TH-302 in Pancreatic Cancer Xenografts.
PLoS One
; 11(5): e0155289, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27227903
20.
Hypoxia-Activated Prodrug TH-302 Targets Hypoxic Bone Marrow Niches in Preclinical Leukemia Models.
Clin Cancer Res
; 22(7): 1687-98, 2016 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26603259