Detalhe da pesquisa
1.
Optimization of allosteric MEK inhibitors. Part 2: Taming the sulfamide group balances compound distribution properties.
Bioorg Med Chem Lett
; 26(1): 186-93, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26611920
2.
A miniaturized mode-of-action profiling platform enables high throughput characterization of the molecular and cellular dynamics of EZH2 inhibition.
Sci Rep
; 14(1): 1739, 2024 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38242973
3.
Optimization of allosteric MEK inhibitors. Part 1: Venturing into underexplored SAR territories.
Bioorg Med Chem Lett
; 23(8): 2384-90, 2013 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23474388
4.
Expanding Chemical Probe Space: Quality Criteria for Covalent and Degrader Probes.
J Med Chem
; 66(14): 9297-9312, 2023 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37403870
5.
Which Small Molecule? Selecting Chemical Probes for Use in Cancer Research and Target Validation.
Cancer Discov
; 13(10): 2150-2165, 2023 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37712569
6.
The 17th EFMC Short Course on Medicinal Chemistry on Small Molecule Protein Degraders.
ChemMedChem
; 18(20): e202300464, 2023 10 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37817354
7.
Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.
ChemMedChem
; 18(8): e202200615, 2023 04 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36749883
8.
Identification and characterization of the new generation soluble guanylate cyclase stimulator BAY-747 designed for the treatment of resistant hypertension.
Br J Pharmacol
; 180(19): 2500-2513, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37170767
9.
The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Hit Generation.
ChemMedChem
; 18(9): e202300002, 2023 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36892096
10.
European Medicinal Chemistry Leaders in Industry (EMCL) - On the Status and Future of Medicinal Chemistry Research in Europe.
ChemMedChem
; 18(13): e202300127, 2023 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37276375
11.
New Generation of sGC Stimulators: Discovery of Imidazo[1,2-a]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension.
J Med Chem
; 66(11): 7280-7303, 2023 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37040336
12.
Targeting the aryl hydrocarbon receptor (AhR) with BAY 2416964: a selective small molecule inhibitor for cancer immunotherapy.
J Immunother Cancer
; 11(11)2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37963637
13.
Target 2035 - an update on private sector contributions.
RSC Med Chem
; 14(6): 1002-1011, 2023 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37360399
14.
Target 2035 - update on the quest for a probe for every protein.
RSC Med Chem
; 13(1): 13-21, 2022 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-35211674
15.
The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Phenotypic Drug Discovery.
ChemMedChem
; 16(11): 1736-1739, 2021 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33825353
16.
Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics*.
ChemMedChem
; 16(7): 1116-1125, 2021 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33513288
17.
Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening.
SLAS Discov
; 26(8): 947-960, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34154424
18.
Electronic and steric control of regioselectivities in Rh(I)-catalyzed (5 + 2) cycloadditions: experiment and theory.
J Am Chem Soc
; 132(29): 10127-35, 2010 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20586494
19.
The European Federation for Medicinal Chemistry (EFMC) Best Practice Initiative: Validating Chemical Probes.
ChemMedChem
; 15(24): 2388-2390, 2020 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32881363
20.
Rules were made to be broken.
Nat Rev Chem
; 7(1): 3-4, 2023 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37117823