Pesquisa | BVS Violência e Saúde

1.

The function of Wtap in N⁶-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells.

Ito-Kureha, Taku; Leoni, Cristina; Borland, Kayla; Cantini, Giulia; Bataclan, Marian; Metzger, Rebecca N; Ammann, Gregor; Krug, Anne B; Marsico, Annalisa; Kaiser, Stefanie; Canzar, Stefan; Feske, Stefan; Monticelli, Silvia; König, Julian; Heissmeyer, Vigo.

Nat Immunol ; 23(8): 1208-1221, 2022 08.

Artigo em Inglês | MEDLINE | ID: mdl-35879451

2.

Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses.

Behrens, Gesine; Edelmann, Stephanie L; Raj, Timsse; Kronbeck, Nina; Monecke, Thomas; Davydova, Elena; Wong, Elaine H; Kifinger, Lisa; Giesert, Florian; Kirmaier, Martin E; Hohn, Christine; de Jonge, Laura S; Pisfil, Mariano Gonzalez; Fu, Mingui; Theurich, Sebastian; Feske, Stefan; Kawakami, Naoto; Wurst, Wolfgang; Niessing, Dierk; Heissmeyer, Vigo.

Nat Immunol ; 22(12): 1563-1576, 2021 12.

Artigo em Inglês | MEDLINE | ID: mdl-34811541

3.

Null and missense mutations of ERI1 cause a recessive phenotypic dichotomy in humans.

Guo, Long; Salian, Smrithi; Xue, Jing-Yi; Rath, Nicola; Rousseau, Justine; Kim, Hyunyun; Ehresmann, Sophie; Moosa, Shahida; Nakagawa, Norio; Kuroda, Hiroshi; Clayton-Smith, Jill; Wang, Juan; Wang, Zheng; Banka, Siddharth; Jackson, Adam; Zhang, Yan-Min; Wei, Zhen-Jie; Hüning, Irina; Brunet, Theresa; Ohashi, Hirofumi; Thomas, Molly F; Bupp, Caleb; Miyake, Noriko; Matsumoto, Naomichi; Mendoza-Londono, Roberto; Costain, Gregory; Hahn, Gabriele; Di Donato, Nataliya; Yigit, Gökhan; Yamada, Takahiro; Nishimura, Gen; Ansel, K Mark; Wollnik, Bernd; Hrabe de Angelis, Martin; Mégarbané, André; Rosenfeld, Jill A; Heissmeyer, Vigo; Ikegawa, Shiro; Campeau, Philippe M.

Am J Hum Genet ; 110(7): 1068-1085, 2023 07 06.

Artigo em Inglês | MEDLINE | ID: mdl-37352860

4.

Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation.

Jeltsch, Katharina M; Hu, Desheng; Brenner, Sven; Zöller, Jessica; Heinz, Gitta A; Nagel, Daniel; Vogel, Katharina U; Rehage, Nina; Warth, Sebastian C; Edelmann, Stephanie L; Gloury, Renee; Martin, Nina; Lohs, Claudia; Lech, Maciej; Stehklein, Jenny E; Geerlof, Arie; Kremmer, Elisabeth; Weber, Achim; Anders, Hans-Joachim; Schmitz, Ingo; Schmidt-Supprian, Marc; Fu, Mingui; Holtmann, Helmut; Krappmann, Daniel; Ruland, Jürgen; Kallies, Axel; Heikenwalder, Mathias; Heissmeyer, Vigo.

Nat Immunol ; 15(11): 1079-89, 2014 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-25282160

5.

Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells.

Essig, Katharina; Hu, Desheng; Guimaraes, Joao C; Alterauge, Dominik; Edelmann, Stephanie; Raj, Timsse; Kranich, Jan; Behrens, Gesine; Heiseke, Alexander; Floess, Stefan; Klein, Juliane; Maiser, Andreas; Marschall, Susan; Hrabe de Angelis, Martin; Leonhardt, Heinrich; Calkhoven, Cornelis F; Noessner, Elfriede; Brocker, Thomas; Huehn, Jochen; Krug, Anne B; Zavolan, Mihaela; Baumjohann, Dirk; Heissmeyer, Vigo.

Immunity ; 47(6): 1067-1082.e12, 2017 12 19.

Artigo em Inglês | MEDLINE | ID: mdl-29246441

6.

Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity.

Schmidt, Henrik; Raj, Timsse; O'Neill, Thomas J; Muschaweckh, Andreas; Giesert, Florian; Negraschus, Arlinda; Hoefig, Kai P; Behrens, Gesine; Esser, Lena; Baumann, Christina; Feederle, Regina; Plaza-Sirvent, Carlos; Geerlof, Arie; Gewies, Andreas; Isay, Sophie E; Ruland, Jürgen; Schmitz, Ingo; Wurst, Wolfgang; Korn, Thomas; Krappmann, Daniel; Heissmeyer, Vigo.

Proc Natl Acad Sci U S A ; 120(48): e2309205120, 2023 Nov 28.

Artigo em Inglês | MEDLINE | ID: mdl-37988467

7.

In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity.

Halle, Stephan; Keyser, Kirsten Anja; Stahl, Felix Rolf; Busche, Andreas; Marquardt, Anja; Zheng, Xiang; Galla, Melanie; Heissmeyer, Vigo; Heller, Katrin; Boelter, Jasmin; Wagner, Karen; Bischoff, Yvonne; Martens, Rieke; Braun, Asolina; Werth, Kathrin; Uvarovskii, Alexey; Kempf, Harald; Meyer-Hermann, Michael; Arens, Ramon; Kremer, Melanie; Sutter, Gerd; Messerle, Martin; Förster, Reinhold.

Immunity ; 44(2): 233-45, 2016 Feb 16.

Artigo em Inglês | MEDLINE | ID: mdl-26872694

8.

Roquin-dependent gene regulation in immune-mediated diseases and future therapies.

Raj, Timsse; Negraschus, Arlinda; Heissmeyer, Vigo.

Int Immunol ; 35(4): 159-170, 2023 04 04.

Artigo em Inglês | MEDLINE | ID: mdl-36525589

9.

The transcription factor NFAT promotes exhaustion of activated CD8âº T cells.

Martinez, Gustavo J; Pereira, Renata M; Äijö, Tarmo; Kim, Edward Y; Marangoni, Francesco; Pipkin, Matthew E; Togher, Susan; Heissmeyer, Vigo; Zhang, Yi Chen; Crotty, Shane; Lamperti, Edward D; Ansel, K Mark; Mempel, Thorsten R; Lähdesmäki, Harri; Hogan, Patrick G; Rao, Anjana.

Immunity ; 42(2): 265-278, 2015 Feb 17.

Artigo em Inglês | MEDLINE | ID: mdl-25680272

10.

Tfh cell differentiation: missing Stat3 uncovers interferons' interference.

Edelmann, Stephanie L; Heissmeyer, Vigo.

Immunity ; 40(3): 307-9, 2014 Mar 20.

Artigo em Inglês | MEDLINE | ID: mdl-24656041

11.

Validation strategies for antibodies targeting modified ribonucleotides.

Weichmann, Franziska; Hett, Robert; Schepers, Aloys; Ito-Kureha, Taku; Flatley, Andrew; Slama, Kaouthar; Hastert, Florian D; Angstman, Nicholas B; Cardoso, M Cristina; König, Julian; Hüttelmaier, Stefan; Dieterich, Christoph; Canzar, Stefan; Helm, Mark; Heissmeyer, Vigo; Feederle, Regina; Meister, Gunter.

RNA ; 26(10): 1489-1506, 2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-32636310

12.

Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression.

Glasmacher, Elke; Hoefig, Kai P; Vogel, Katharina U; Rath, Nicola; Du, Lirui; Wolf, Christine; Kremmer, Elisabeth; Wang, Xiaozhong; Heissmeyer, Vigo.

Nat Immunol ; 11(8): 725-33, 2010 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-20639877

13.

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.

Vogel, Katharina U; Edelmann, Stephanie L; Jeltsch, Katharina M; Bertossi, Arianna; Heger, Klaus; Heinz, Gitta A; Zöller, Jessica; Warth, Sebastian C; Hoefig, Kai P; Lohs, Claudia; Neff, Frauke; Kremmer, Elisabeth; Schick, Joel; Repsilber, Dirk; Geerlof, Arie; Blum, Helmut; Wurst, Wolfgang; Heikenwälder, Mathias; Schmidt-Supprian, Marc; Heissmeyer, Vigo.

Immunity ; 38(4): 655-68, 2013 Apr 18.

Artigo em Inglês | MEDLINE | ID: mdl-23583643

14.

A translational silencing function of MCPIP1/Regnase-1 specified by the target site context.

Behrens, Gesine; Winzen, Reinhard; Rehage, Nina; Dörrie, Anneke; Barsch, Monika; Hoffmann, Anne; Hackermüller, Jörg; Tiedje, Christopher; Heissmeyer, Vigo; Holtmann, Helmut.

Nucleic Acids Res ; 46(8): 4256-4270, 2018 05 04.

Artigo em Inglês | MEDLINE | ID: mdl-29471506

15.

Induced miR-99a expression represses Mtor cooperatively with miR-150 to promote regulatory T-cell differentiation.

Warth, Sebastian C; Hoefig, Kai P; Hiekel, Anian; Schallenberg, Sonja; Jovanovic, Ksenija; Klein, Ludger; Kretschmer, Karsten; Ansel, K Mark; Heissmeyer, Vigo.

EMBO J ; 34(9): 1195-213, 2015 May 05.

Artigo em Inglês | MEDLINE | ID: mdl-25712478

16.

OX40L blockade protects against inflammation-driven fibrosis.

Elhai, Muriel; Avouac, Jérôme; Hoffmann-Vold, Anna Maria; Ruzehaji, Nadira; Amiar, Olivia; Ruiz, Barbara; Brahiti, Hassina; Ponsoye, Matthieu; Fréchet, Maxime; Burgevin, Anne; Pezet, Sonia; Sadoine, Jérémy; Guilbert, Thomas; Nicco, Carole; Akiba, Hisaya; Heissmeyer, Vigo; Subramaniam, Arun; Resnick, Robert; Molberg, Øyvind; Kahan, André; Chiocchia, Gilles; Allanore, Yannick.

Proc Natl Acad Sci U S A ; 113(27): E3901-10, 2016 07 05.

Artigo em Inglês | MEDLINE | ID: mdl-27298374

17.

Molecular control of Tfh-cell differentiation by Roquin family proteins.

Heissmeyer, Vigo; Vogel, Katharina U.

Immunol Rev ; 253(1): 273-89, 2013 May.

Artigo em Inglês | MEDLINE | ID: mdl-23550652

18.

Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation.

Eitelhuber, Andrea C; Warth, Sebastian; Schimmack, Gisela; Düwel, Michael; Hadian, Kamyar; Demski, Katrin; Beisker, Wolfgang; Shinohara, Hisaaki; Kurosaki, Tomohiro; Heissmeyer, Vigo; Krappmann, Daniel.

EMBO J ; 30(3): 594-605, 2011 Feb 02.

Artigo em Inglês | MEDLINE | ID: mdl-21157432

19.

Itching to end NF-kappaB.

Heissmeyer, Vigo; Rao, Anjana.

Nat Immunol ; 9(3): 227-9, 2008 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-18285770

20.

Cyclin-dependent kinase 9 links RNA polymerase II transcription to processing of ribosomal RNA.

Burger, Kaspar; Mühl, Bastian; Rohrmoser, Michaela; Coordes, Britta; Heidemann, Martin; Kellner, Markus; Gruber-Eber, Anita; Heissmeyer, Vigo; Strässer, Katja; Eick, Dirk.

J Biol Chem ; 288(29): 21173-21183, 2013 Jul 19.

Artigo em Inglês | MEDLINE | ID: mdl-23744076

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